Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages

(2022) Libin Ni et al.   BIOCHEMICAL PHARMACOLOGY

Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

(2022) Eswara Rao Puppala et al.   PHYTOMEDICINE

Unfolding Nrf2 in diabetes mellitus

(2021) Tapan Behl et al.   MOLECULAR BIOLOGY REPORTS

Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes

(2021) Hai Jia et al.   Nutrients

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

(2021) María Luisa Castejón et al.   Nutrients

Prevalence and incidence of microvascular and macrovascular complications over 15 years among patients with incident type 2 diabetes

(2021) Jaejin An et al.   BMJ Open Diabetes Research & Care

Food-Derived Pharmacological Modulators of the Nrf2/ARE Pathway: Their Role in the Treatment of Diseases

(2021) Feijie Zhao et al.   MOLECULES

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity

(2021) Rafael Ferraz-Bannitz et al.   Diabetology & Metabolic Syndrome

Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling

(2021) Md Jamal Uddin et al.   Antioxidants

Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund's adjuvant-induced arthritis in rats

(2021) Roshan Lal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

(2021) Tian Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kurarinone Attenuates Collagen-Induced Arthritis in Mice by Inhibiting Th1/Th17 Cell Responses and Oxidative Stress

(2021) Kuo-Tung Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic potential of Nrf-2 pathway in the treatment of diabetic neuropathy and nephropathy

(2021) Amit Gupta et al.   MOLECULAR BIOLOGY REPORTS

A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases

(2021) Abu Mohammad Syed et al.   PHYTOTHERAPY RESEARCH

Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities

(2021) Monica Margoni et al.   Frontiers in Neurology

Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future

(2021) Carla Iacobini et al.   Antioxidants

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2

(2021) Peter Stenvinkel et al.   Kidney International Reports

Role of oxidative stress in pathophysiology of rheumatoid arthritis: insights into NRF2-KEAP1 signalling

(2021) Gurjasmine Kaur et al.   AUTOIMMUNITY

The role of CD8+ T-cell systemic lupus erythematosus pathogenesis

(2021) Ping-Min Chen et al.   CURRENT OPINION IN RHEUMATOLOGY

Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice

(2021) Ji Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

AGA Technical Review on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease

(2021) Siddharth Singh et al.   GASTROENTEROLOGY

AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease

(2021) Joseph D. Feuerstein et al.   GASTROENTEROLOGY

Curculigoside attenuates oxidative stress and osteoclastogenesis via modulating Nrf2/NF-κB signaling pathway in RAW264.7 cells

(2021) Mengqin Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation

(2021) Yen-Chang Chen et al.   Frontiers in Pharmacology

Targeting Canonical and Non-Canonical STAT Signaling Pathways in Renal Diseases

(2021) Lili Gai et al.   Cells

Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway

(2021) Bercis Imge Ucar et al.   Antioxidants

Lutein as a Modulator of Oxidative Stress-Mediated Inflammatory Diseases

(2021) Yu Jin Ahn et al.   Antioxidants

Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization

(2021) Shin-Young Gwak et al.   Gut and Liver

The Role of NLRP3 Inflammasome in Lupus Nephritis

(2021) Camila Barbosa Oliveira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases

(2021) Madhu Ramaswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB

(2021) Hongchu Bao et al.   MEDIATORS OF INFLAMMATION

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis

(2021) Chenghao Ren et al.   Frontiers in Pharmacology

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

(2020) Sarah K. Madden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy

(2020) Temitope Isaac Adelusi et al.   BIOMEDICINE & PHARMACOTHERAPY

AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis

(2020) Joseph D. Feuerstein et al.   GASTROENTEROLOGY

AGA Technical Review on the Management of Moderate to Severe Ulcerative Colitis

(2020) Siddharth Singh et al.   GASTROENTEROLOGY

MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress

(2020) Milad Ashrafizadeh et al.   LIFE SCIENCES

Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy

(2020) Karen L. Madsen et al.   NEUROLOGY

NRF2 deficiency increases obesity susceptibility in a mouse menopausal model

(2020) Xunwei Wu et al.   PLoS One

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

(2020) Hui Liu et al.   Cell Death & Disease

Nrf2 in adipocytes

(2020) Zhendi Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Beyond repression of Nrf2: An update on Keap1

(2020) Aleksandra Kopacz et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice

(2020) Dong Ho Lee et al.   Nutrients

Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial

(2020) Ardalan H Zolnourian et al.   BMJ Open

The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives

(2020) Emiliano Panieri et al.   Biomolecules

NRF2, a Transcription Factor for Stress Response and Beyond

(2020) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent advances in the treatment of Niemann pick disease type C: A mini-review

(2020) Adrián Matencio et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Protective role of NRF2 in macrovascular complications of diabetes

(2020) Junduo Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

(2020) Liliya V. Vasileva et al.   PHARMACOLOGICAL RESEARCH

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

(2020) Sharadha Dayalan Naidu et al.   Open Biology

NF ‐E2–Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus

(2020) Shuhong Han et al.   Arthritis & Rheumatology

Current Landscape of NRF2 Biomarkers in Clinical Trials

(2020) Yoko Yagishita et al.   Antioxidants

Safety and Efficacy of Omaveloxolone in Friedreich's Ataxia ( MOXIe Study)

(2020) David R. Lynch et al.   ANNALS OF NEUROLOGY

Imperatorin Relieved Ulcerative Colitis by Regulating the Nrf-2/ARE/HO-1 Pathway in Rats

(2020) Min Luo et al.   INFLAMMATION

Dimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis

(2020) Sheng Zhang et al.   INFLAMMATION

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

(2020) Shiri Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway

(2020) Fatma M. Amin et al.   LIFE SCIENCES

Altered oxidative stress markers in relation to T cells, NK cells & killer immunoglobulin receptors that are associated with disease activity in SLE patients

(2020) Ankit Tandon et al.   LUPUS

Role of Nrf2 in cell senescence regulation

(2020) Huan Yuan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

(2020) Marta Piotrowska et al.   PHARMACOLOGICAL RESEARCH

Treatment for mitochondrial diseases

(2020) Tongling Liufu et al.   REVIEWS IN THE NEUROSCIENCES

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

(2020) Marina Galicia-Moreno et al.   Antioxidants

Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

(2020) Stephanie Kourakis et al.   Pharmaceuticals

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021

(2020)   DIABETES CARE

11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2021

(2020)   DIABETES CARE

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Nrf2: The Master and Captain of Beta Cell Fate

(2020) Sharon Baumel-Alterzon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1/HO-1 axis in inflammatory bowel diseases

(2020) Dun Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs

(2019) Pelin Telkoparan-Akillilar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress pathways in pancreatic beta cells and insulin sensitive cells and tissues - importance to cell metabolism, function and dysfunction

(2019) Philip Newsholme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function

(2019) Zhiyong Wen et al.   Oxidative Medicine and Cellular Longevity

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

(2019) Ye Zhang et al.   Annals of the New York Academy of Sciences

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

(2019) Gordon C. Weir   DIABETES

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

(2019) Christopher Andrew Lamb et al.   GUT

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition

(2019) Minglei Lu et al.   Redox Biology

Maresin 1 alleviates dextran sulfate sodium-induced ulcerative colitis by regulating NRF2 and TLR4/NF-kB signaling pathway

(2019) Shujin Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases

(2019) Akihito Otsuki et al.   ARCHIVES OF PHARMACAL RESEARCH

Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice

(2019) Patricia Klemm et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

(2018) Dionysios V Chartoumpekis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes

(2018) Ying Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Contribution of NRF2 in Gastrointestinal Protection From Oxidative Injury

(2018) Akinori Yanaka   CURRENT PHARMACEUTICAL DESIGN

M1/M2 macrophages in diabetic nephropathy: Nrf2/HO-1 as therapeutic targets

(2018) R. Clive Landis et al.   CURRENT PHARMACEUTICAL DESIGN

Role of NRF2 in protection of the gastrointestinal tract against oxidative stress

(2018) Akinori Yanaka   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Bardoxolone—the Phoenix?

(2018) Robert D. Toto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transcription Factors as Therapeutic Targets in Chronic Kidney Disease

(2018) Akihito Hishikawa et al.   MOLECULES

The regulatory role of Nrf2 in antioxidants phase2 enzymes and IL-17A expression in patients with ulcerative colitis

(2018) Milad Sabzevary-Ghahfarokhi et al.   PATHOLOGY RESEARCH AND PRACTICE

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier

(2018) Danyvid Olivares-Villagómez et al.   TRENDS IN IMMUNOLOGY

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors

(2018) Raeeka Khamari et al.   Cell Death & Disease

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

(2018) Wei-Yin Wu et al.   Frontiers in Pharmacology

The putative interplay between DJ-1/NRF2 and Dimethyl Fumarate: A potentially important pharmacological target

(2018) George Vavougios et al.   Multiple Sclerosis and Related Disorders

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Nrf2 activator for the treatment of kidney diseases

(2018) Kengo Yamawaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

(2018) Jin-Fang Luo et al.   Frontiers in Pharmacology

Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress

(2018) Jia Fang et al.   Aging-US

Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: The basic considerations

(2018) Chander K. Negi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of iNOS on Immune Cells and Its Role in Diseases

(2018) Qingjie Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop

(2018) Menglin Fan et al.   Frontiers in Immunology

Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk

(2018) Sameh Saber et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 suppresses the function of dendritic cells to facilitate the immune escape of glioma cells

(2017) Jialiang Wang et al.   EXPERIMENTAL CELL RESEARCH

Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2

(2017) Renu A. Kowluru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extracellular Signal-Regulated Kinase/Nuclear Factor-Erythroid2-like2/Heme Oxygenase-1 Pathway-Mediated Mitophagy Alleviates Traumatic Brain Injury-Induced Intestinal Mucosa Damage and Epithelial Barrier Dysfunction

(2017) Yinlong Liu et al.   JOURNAL OF NEUROTRAUMA

Involvement of Nrf2 in Ocular Diseases

(2017) Shehzad Batliwala et al.   Oxidative Medicine and Cellular Longevity

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

(2017) Albena T. Dinkova-Kostova et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes

(2017) Ana Pereira et al.   Scientific Reports

The intestinal barrier: a fundamental role in health and disease

(2017) Maaike Vancamelbeke et al.   Expert Review of Gastroenterology & Hepatology

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Nrf2: a potential therapeutic target for diabetic neuropathy

(2017) Anil Kumar et al.   INFLAMMOPHARMACOLOGY

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

(2016) Stephen L. Slocum et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes MellitusHighlights

(2016) Kazuyuki Yahagi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Vascular Complications of Diabetes

(2016) Joshua A. Beckman et al.   CIRCULATION RESEARCH

Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy

(2016) Seyed Fazel Nabavi et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

(2016) Jay S. Skyler et al.   DIABETES

Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

(2016) Suchitra Kumari Panigrahy et al.   JOURNAL OF DRUG TARGETING

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice

(2016) Noha M. Shawky et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta

(2016) T. Matsui et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Glycosylation enables aesculin to activate Nrf2

(2016) Kyun Ha Kim et al.   Scientific Reports

Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose

(2016) Kazuhiro Yanagida et al.   Aging-US

Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function

(2016) Mei Zhao et al.   Scientific Reports

The Keap1–Nrf2 system and diabetes mellitus

(2015) Akira Uruno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NRF2 and microRNAs: new but awaited relations

(2015) Svitlana Kurinna et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation

(2015) Yanwei Wu et al.   Cellular & Molecular Immunology

Role of Nrf2 in the pathogenesis of atherosclerosis

(2015) Junsei Mimura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

(2015) Lisa K. Sha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic regulation of Keap1-Nrf2 signaling

(2015) Yue Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl Fumarate Reduces Inflammatory Responses in Experimental Colitis

(2015) Giovanna Casili et al.   Journal of Crohns & Colitis

T Lymphocyte-Specific Activation of Nrf2 Protects from AKI

(2015) S. Noel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes

(2015) Elango Bhakkiyalakshmi et al.   PHARMACOLOGICAL RESEARCH

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

(2015) Sílvia S. Chambel et al.   Biomed Research International

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Heme oxygenase-1 and anti-inflammatory M2 macrophages

(2014) Yuji Naito et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption

(2014) Wei Ling Lau et al.   DIGESTIVE DISEASES AND SCIENCES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function

(2014) Yonggang Wang et al.   Oxidative Medicine and Cellular Longevity

The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome

(2014) Zhiguo Zhang et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Prevention of Murine Lupus Nephritis by Targeting Multiple Signaling Axes and Oxidative Stress Using a Synthetic Triterpenoid

(2014) Tianfu Wu et al.   Arthritis & Rheumatology

The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice

(2014) Leo R. Fitzpatrick et al.   INFLAMMOPHARMACOLOGY

Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats

(2013) Xian Fan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes

(2013) Gopal V. Velmurugan et al.   CARDIOVASCULAR RESEARCH

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium

(2013) Hao Chen et al.   GUT

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response

(2013) Tao Jiang et al.   KIDNEY INTERNATIONAL

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

(2013) Hyun-Ae Seo et al.   Oxidative Medicine and Cellular Longevity

Concepts of oxidative stress and antioxidant defense in Crohn’s disease

(2013) Mohammed A Alzoghaibi   WORLD JOURNAL OF GASTROENTEROLOGY

The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives

(2012) Meenakshi B. Kannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

(2012) J. Xu et al.   DIABETES

Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome

(2012) P. Xue et al.   DIABETES

Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006: Findings from the National Health Interview Survey

(2012) E. W. Gregg et al.   DIABETES CARE

When less is more: the forbidden fruits of gene repression in the adult β-cell

(2012) T. J. Pullen et al.   DIABETES OBESITY & METABOLISM

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence

(2012) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy

(2012) Bing Li et al.   Experimental Diabetes Research

The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops

(2012) Diána Papp et al.   FEBS LETTERS

Th2 Skewing by Activation of Nrf2 in CD4+ T Cells

(2012) C. E. Rockwell et al.   JOURNAL OF IMMUNOLOGY

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

(2012) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis

(2011) Xiaoni Kong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications

(2011) Young-Sam Keum   Annals of the New York Academy of Sciences

Role of oxidative stress and antioxidant enzymes in Crohn's disease

(2011) Marisa Iborra et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

(2011) Y. Zhang   CARCINOGENESIS

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Nrf2 and NF-κB Modulation by Sulforaphane Counteracts Multiple Manifestations of Diabetic Neuropathy in Rats and High Glucose-Induced Changes

(2011) Geeta Negi et al.   CURRENT NEUROVASCULAR RESEARCH

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

(2011) Hongting Zheng et al.   DIABETES

Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

(2011) D. V. Chartoumpekis et al.   DIABETES

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

(2011) Ildefonso Rodríguez-Ramiro et al.   EUROPEAN JOURNAL OF NUTRITION

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis

(2011) Yongyong Hou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial

(2011) Sang Geon Kim et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?

(2011) X. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Enhanced Hepatic Nrf2 Activation After Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis

(2010) Kazuhito Kawata et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Autoregulatory Loop between Nrf2 and Cul3-Rbx1 Controls Their Cellular Abundance

(2010) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice

(2009) Arianne L. Theiss et al.   GASTROENTEROLOGY

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

(2009) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

(2008) Kosuke Okada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells

(2008) Sakiko Arisawa et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH