Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
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Title
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Authors
Keywords
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Journal
NATURE
Volume 556, Issue 7699, Pages 113-117
Publisher
Springer Nature
Online
2018-03-27
DOI
10.1038/nature25986
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Note: Only part of the references are listed.- Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly
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- Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages
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- Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
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- IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid
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- The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione
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- Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro
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- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
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- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
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- Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
- (2011) C. A. Dinarello BLOOD
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- (2011) Ralf A. Linker et al. BRAIN
- Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
- (2011) Stefan Freigang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
- (2011) Greta Guarda et al. IMMUNITY
- Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression
- (2011) Claude A. Piantadosi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation
- (2011) Cheryl L. Strelko et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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