Redox Regulation of STAT1 and STAT3 Signaling

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

(2020) S. Busker et al.   Science Advances

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia

(2019) Elena Butturini et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The potential and controversy of targeting STAT family members in cancer

(2019) Yannick Verhoeven et al.   SEMINARS IN CANCER BIOLOGY

Cysteine Glutathionylation Acts as a Redox Switch in Endothelial Cells

(2019) Lermant et al.   Antioxidants

S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia

(2018) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

(2018) Marcus Grohmann et al.   CELL

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol–Disulfide Exchange between Protein Thiols and Glutathione

(2018) Zhiguang Xiao et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation

(2018) Guo-Juan Niu et al.   Frontiers in Immunology

Glutaredoxin catalysis requires two distinct glutathione interaction sites

(2017) Patricia Begas et al.   Nature Communications

Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function

(2016) E. Butturini et al.   BIOCHEMICAL JOURNAL

Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction

(2016) Jaganathan Subramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression

(2016) Cecilia Dallavalle et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation

(2014) Elena Butturini et al.   ACS Chemical Biology

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

(2014) Sutapa Ray et al.   CELLULAR SIGNALLING

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease

(2013) Jinsu Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Generation of Prostate Tumor-Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling

(2013) Y. Qu et al.   CANCER RESEARCH

Regulation of STAT signaling by acetylation

(2013) Shougang Zhuang   CELLULAR SIGNALLING

Suppression of cytokine signaling: The SOCS perspective

(2013) Edmond M. Linossi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

(2013) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo redox state of Human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

(2012) J. Ungerstedt et al.   FREE RADICAL BIOLOGY AND MEDICINE

The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

(2012) Edmond M. Linossi et al.   IUBMB LIFE

Smurf1 Protein Negatively Regulates Interferon-γ Signaling through Promoting STAT1 Protein Ubiquitination and Degradation

(2012) Chao Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive

(2012) Carlos Zgheib et al.   PLoS One

Oxidative Modification of Proteins: An Emerging Mechanism of Cell Signaling

(2012) Stephanie B. Wall et al.   Frontiers in Physiology

The Structure of the Thioredoxin–Triosephosphate Isomerase Complex Provides Insights into the Reversible Glutathione-Mediated Regulation of Triosephosphate Isomerase

(2011) Shahul Hameed M. S. et al.   BIOCHEMISTRY

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3

(2011) T. Tanaka et al.   Science Signaling

Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage

(2010) Koji Osuka et al.   BRAIN RESEARCH

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

Lysine methylation of promoter-bound transcription factors and relevance to cancer

(2010) George R Stark et al.   CELL RESEARCH

Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation

(2010) In-Hee Park et al.   JOURNAL OF MOLECULAR RECOGNITION

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 deletion sensitizes cells to oxidative stress

(2009) Seán P. Barry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitrosothiol Reactivity Profiling Identifies S-Nitrosylated Proteins with Unexpected Stability

(2008) Jeremy S. Paige et al.   CHEMISTRY & BIOLOGY

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling

(2008) Yi Xie et al.   ENDOCRINOLOGY

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

(2008) N. Wenta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING