Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

(2016) Lan Xiang et al.   Aging-US

Ameliorative efficacy of tetrahydrocurcumin against arsenic induced oxidative damage, dyslipidemia and hepatic mitochondrial toxicity in rats

(2015) M. Muthumani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms

(2015) K.B. King et al.   OSTEOARTHRITIS AND CARTILAGE

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Investigation of antibacterial and biofilm inhibition activity of Michelia figo leaf extracts against dental bacterium

(2015) X Song et al.   PLANTA MEDICA

The epidemiology of osteoarthritis

(2014) Victoria L. Johnson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Supplementing with Opuntia ficus-indica Mill and Dioscorea nipponica Makino extracts synergistically attenuates menopausal symptoms in estrogen-deficient rats

(2014) Byoung-Seob Ko et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rose hip alleviates pain and disease progression in rats with monoiodoacetate induced osteoarthritis

(2014) Sunmin Park et al.   Journal of the Korean Society for Applied Biological Chemistry

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

(2014) Bharat Aggarwal et al.   MOLECULES

Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis

(2014) A.K. Suokas et al.   OSTEOARTHRITIS AND CARTILAGE

Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial

(2014) Yunes Panahi et al.   PHYTOTHERAPY RESEARCH

Tetrahydrocurcumin Protects against Cadmium-Induced Hypertension, Raised Arterial Stiffness and Vascular Remodeling in Mice

(2014) Weerapon Sangartit et al.   PLoS One

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

(2014) E. Thijssen et al.   RHEUMATOLOGY

Estrogen Deficiency and the Origin of Obesity during Menopause

(2014) Fernando Lizcano et al.   Biomed Research International

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats

(2013) Laura J. Leys et al.   PAIN

Chemopreventative effects of tetrahydrocurcumin on human diseases

(2013) Jia-Ching Wu et al.   Food & Function

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

Impact of diabetes and its treatments on skeletal diseases

(2013) Wenbo Yan et al.   Frontiers of Medicine

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis

(2012) Longhuo Wu et al.   CURRENT PHARMACEUTICAL DESIGN

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition Effect of Curcumin on TNF-a and MMP-13 Expression Induced by Advanced Glycation End Products in Chondrocytes

(2012) Qingshan Yang et al.   PHARMACOLOGY

Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs

(2012) M. Colitti et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Osteoarthritis year 2010 in review: pathomechanisms

(2011) W.B. van den Berg   OSTEOARTHRITIS AND CARTILAGE

Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro

(2010) Mehdi Shakibaei et al.   Genes and Nutrition

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

(2009) S. Bar-Yehuda et al.   ARTHRITIS AND RHEUMATISM

Targeting Matrix Metalloproteinases in Inflammatory Conditions

(2009) A. Clutterbuck et al.   CURRENT DRUG TARGETS

Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin

(2009) Guang Liang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats

(2008) J. Cacho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats

(2008) Sushil K. Jain et al.   ANTIOXIDANTS & REDOX SIGNALING

Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-κB activation in RAW264.7 macrophages activated with LPS

(2008) Hyun-Ock Pae et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY