The Inflammasomes: Guardians of the Body

NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells

(2014) M. Vinzing et al.   JOURNAL OF IMMUNOLOGY

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm

(2014) H. Hara et al.   JOURNAL OF IMMUNOLOGY

Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection

(2014) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

Danger Signaling through the Inflammasome Acts as a Master Switch between Tolerance and Sensitization

(2014) Hideki Watanabe et al.   JOURNAL OF IMMUNOLOGY

TLR9 as a key receptor for the recognition of DNA☆

(2008) Y KUMAGAI et al.   ADVANCED DRUG DELIVERY REVIEWS

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Successful treatment of resistant pseudogout with anakinra

(2008) Dennis McGonagle et al.   ARTHRITIS AND RHEUMATISM

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF- B through its N-terminal fragment

(2008) J. J. Chae et al.   BLOOD

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish

(2008) Kerry J Laing et al.   BMC EVOLUTIONARY BIOLOGY

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Plant NB-LRR Immune Receptors: From Recognition to Transcriptional Reprogramming

(2008) Jeffrey Caplan et al.   Cell Host & Microbe

The leucine-rich repeat structure

(2008) J. Bella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway

(2008) Katherine E. Wickliffe et al.   CELLULAR MICROBIOLOGY

Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax Lethal Toxin

(2008) Núria Reig et al.   CELLULAR MICROBIOLOGY

NLRX1: friend or foe?

(2008) Etienne Meylan et al.   EMBO REPORTS

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

(2008) Bin Li et al.   IMMUNOLOGY

Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity

(2008) Juying Li et al.   JOURNAL OF CELL BIOLOGY

UV irradiation increases ROS production via PKCδ signaling in primary murine fibroblasts

(2008) Orit Bossi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Acute Neurodegeneration and the Inflammasome: Central Processor for Danger Signals and the Inflammatory Response?

(2008) George Trendelenburg   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different Evolutionary Strategies for the Origin of Caspase-1 Inhibitors

(2008) Júlia P. C. da Cunha et al.   JOURNAL OF MOLECULAR EVOLUTION

Identification of oocyte-selectiveNLRPgenes in rhesus macaque monkeys (Macaca mulatta)

(2008) Patrick McDaniel et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Inhibition of Anthrax Lethal Toxin-Induced Cytolysis of RAW264.7 Cells by Celastrol

(2008) Sarah Chapelsky et al.   PLoS One

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confinement of caspase-12 proteolytic activity to autoprocessing

(2008) S. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Plasmodium-Induced Inflammation by Uric Acid

(2008) Jamie M. Orengo et al.   PLoS Pathogens

Engagement of NOD2 has a dual effect on proIL-1β mRNA transcription and secretion of bioactive IL-1β

(2007) Gerben Ferwerda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY