Specificity, versatility, and control of TGF-β family signaling

Regulation of RabGAPs involved in insulin action

(2018) Samaneh Mafakheri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

(2018) Yan Qin et al.   CELL

Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation

(2018) Viet Q Le et al.   EMBO JOURNAL

Arginine methylation of Smad7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem cell generation

(2018) Yoko Katsuno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

(2018) Harinarayanan Janakiraman et al.   MOLECULAR CANCER RESEARCH

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

(2018) Anassuya Ramachandran et al.   eLife

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

(2018) Philippe Lucarelli et al.   Cell Systems

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

(2018) Stéphanie Liénart et al.   SCIENCE

Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences

(2017) Edward N. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD3

(2017) Victoria G. Shuttleworth et al.   JOURNAL OF CELL SCIENCE

High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells

(2017) Kazuki Fukami et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Role of GARP in the activation of latent TGF-β1

(2017) Julie Stockis et al.   Molecular BioSystems

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

(2017) Davide Pradella et al.   Molecular Cancer

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

(2017) Anahita Hamidi et al.   Science Signaling

The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration

(2017) J. Manuel Hernández-Hernández et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

(2017) Christian Siebold et al.   TRENDS IN CELL BIOLOGY

TGF-β Family Signaling in Mesenchymal Differentiation

(2017) Ingo Grafe et al.   Cold Spring Harbor Perspectives in Biology

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

(2017) Alan C. Mullen et al.   Cold Spring Harbor Perspectives in Biology

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease

(2017) Marie-José Goumans et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Connective Tissue and Skeletal Diseases

(2017) Elena Gallo MacFarlane et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

(2017) Pau Martin-Malpartida et al.   Nature Communications

Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

(2017) Tessa G Montague et al.   eLife

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

(2017) Anahita Hamidi et al.   Science Signaling

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Endocytosis and trafficking of BMP receptors: Regulatory mechanisms for fine-tuning the signaling response in different cellular contexts

(2016) Marcelo Ehrlich   CYTOKINE & GROWTH FACTOR REVIEWS

Regulation of the TGF-β pathway by deubiquitinases in cancer

(2016) Sijia Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

(2016) Alexander P. Wohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition

(2016) Yueqin Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β

(2016) Veenu Tripathi et al.   MOLECULAR CELL

Agonists and Antagonists of TGF-β Family Ligands

(2016) Chenbei Chang   Cold Spring Harbor Perspectives in Biology

Activins and Inhibins: Roles in Development, Physiology, and Disease

(2016) Maria Namwanje et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads

(2016) Apirat Chaikuad et al.   Cold Spring Harbor Perspectives in Biology

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Posttranslational Regulation of Smads

(2016) Pinglong Xu et al.   Cold Spring Harbor Perspectives in Biology

The Discovery and Early Days of TGF-β: A Historical Perspective

(2016) Harold L. Moses et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

(2016) Yun Zhang et al.   Cold Spring Harbor Perspectives in Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification

(2016) Ling Liu et al.   Scientific Reports

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

(2016) Maximilianos Elkouris et al.   Cell Reports

Signaling-Mediated Regulation of MicroRNA Processing

(2015) J. Shen et al.   CANCER RESEARCH

TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor

(2015) Reshma Sundar et al.   CELL CYCLE

Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation

(2015) Fenfang Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

STAT3 selectively interacts with Smad3 to antagonize TGF-β

(2015) G Wang et al.   ONCOGENE

Structure of bone morphogenetic protein 9 procomplex

(2015) Li-Zhi Mi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

(2015) Erine H. Budi et al.   Science Signaling

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin

(2015) Justin B. Goh et al.   Scientific Reports

ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

(2015) Baby Periyanayaki Muthusamy et al.   PLOS BIOLOGY

The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

(2015) Erine H. Budi et al.   Science Signaling

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition

(2014) Rik Derynck et al.   CURRENT OPINION IN CELL BIOLOGY

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

(2014) Christophe Fuerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis

(2014) Zhenquan Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

(2014) Monica D. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal Domain (CTD) Small Phosphatase-like 2 Modulates the Canonical Bone Morphogenetic Protein (BMP) Signaling and Mesenchymal Differentiation via Smad Dephosphorylation

(2014) Yulan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

(2014) Helena Porsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

(2014) Xiwu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β

(2014) Keren E. Shapira et al.   MOLECULAR BIOLOGY OF THE CELL

Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling

(2014) Pinglong Xu et al.   MOLECULAR CELL

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRAF6 Stimulates the Tumor-Promoting Effects of TGF  Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

(2014) S. K. Gudey et al.   Science Signaling

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF- 

(2014) R. C. J. D'Souza et al.   Science Signaling

Advances in kinase targeting: current clinical use and clinical trials

(2014) Mathias Rask-Andersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The regulation of TGF-β/SMAD signaling by protein deubiquitination

(2014) Juan Zhang et al.   Protein & Cell

N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding

(2013) Jonathan W. Lowery et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6

(2013) Xiaofei Zhang et al.   EMBO JOURNAL

Stabilization of Snail through AKT/GSK-3β signaling pathway is required for TNF-α-induced epithelial–mesenchymal transition in prostate cancer PC3 cells

(2013) Hao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zinc Finger Protein 451 Is a Novel Smad Corepressor in Transforming Growth Factor-β Signaling

(2013) Yili Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome

(2013) Xueqian Yin et al.   MOLECULAR BIOLOGY OF THE CELL

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

(2013) Wei Zuo et al.   MOLECULAR CELL

Arginine Methylation Initiates BMP-Induced Smad Signaling

(2013) Jian Xu et al.   MOLECULAR CELL

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis

(2013) Long Zhang et al.   MOLECULAR CELL

Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling

(2013) Chenxi Tian et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Increase of O-Glycosylated Oncofetal Fibronectin in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Epithelial Cells

(2013) Frederico Alisson-Silva et al.   PLoS One

Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus

(2013) XiaoHua Yan et al.   Science China-Life Sciences

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

(2013) Su Myung Jung et al.   Nature Communications

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor

(2012) Young-Woong Kim et al.   BIOCHEMICAL JOURNAL

Oligomeric interactions of TGF-β and BMP receptors

(2012) Marcelo Ehrlich et al.   FEBS LETTERS

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

(2012) Hui-Yi Kua et al.   NATURE CELL BIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mechanisms of Smad binding

(2012) M Morikawa et al.   ONCOGENE

A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing

(2012) T. Akiyama et al.   Science Signaling

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Morphogen Gradients: From Generation to Interpretation

(2011) Katherine W. Rogers et al.   Annual Review of Cell and Developmental Biology

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

(2011) Liu-Ya Tang et al.   EMBO JOURNAL

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

An evolving web of signaling networks regulated by Cripto-1

(2011) Tadahiro Nagaoka et al.   GROWTH FACTORS

Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli

(2011) Anahita Hamidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Requirements for Proteolytic Processing of Bone Morphogenetic Protein 5/6/7/8 Ligands inDrosophila melanogaster

(2011) Cornelia Fritsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone 3 Lysine 9 (H3K9) Methyltransferase Recruitment to the Interleukin-2 (IL-2) Promoter Is a Mechanism of Suppression of IL-2 Transcription by the Transforming Growth Factor-β-Smad Pathway

(2011) Yu Wakabayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Betaglycan: A multifunctional accessory

(2011) Maree Bilandzic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

(2011) Eleonora Agricola et al.   MOLECULAR CELL

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

(2011) Masato Morikawa et al.   NUCLEIC ACIDS RESEARCH

Smad3 regulates E-cadherin via miRNA-200 pathway

(2011) S-M Ahn et al.   ONCOGENE

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

(2011) K Horiguchi et al.   ONCOGENE

Specificity of Drosophila Cytonemes for Distinct Signaling Pathways

(2011) S. Roy et al.   SCIENCE

Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension

(2011) Yang-Kao Wang et al.   STEM CELLS AND DEVELOPMENT

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

(2010) L. J. A. C. Hawinkels et al.   CANCER RESEARCH

Alternative splicing of SMADs in differentiation and tissue homeostasis

(2010) Shijie Tao et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes

(2010) Junjing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction

(2010) Yuto Kamiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes

(2010) Christoph Meyer et al.   JOURNAL OF HEPATOLOGY

PARP-1 Attenuates Smad-Mediated Transcription

(2010) Peter Lönn et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy

(2009) Liyu Wu et al.   DEVELOPMENTAL CELL

Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β Signaling

(2009) Fangyan Dai et al.   DEVELOPMENTAL CELL

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane

(2009) Fredrick D. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement of a dynein light chain in TGFβ/Smad3 signaling

(2009) Qunyan Jin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

BMP-4 Induction of Arrest and Differentiation of Osteoblast-Like Cells via p21CIP1and p27KIP1Regulation

(2009) Shun-Fu Chang et al.   MOLECULAR ENDOCRINOLOGY

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Single-molecule imaging reveals transforming growth factor- -induced type II receptor dimerization

(2009) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Insulin action on glucose transporters through molecular switches, tracks and tethers

(2008) Hilal Zaid et al.   BIOCHEMICAL JOURNAL

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Regulating the stability of TGFβ receptors and Smads

(2008) Peter Lönn et al.   CELL RESEARCH

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

Two highly related regulatory subunits of PP2A exert opposite effects on TGF- /Activin/Nodal signalling

(2008) J. Batut et al.   DEVELOPMENT

VE-cadherin is a critical endothelial regulator of TGF-β signalling

(2008) Noemi Rudini et al.   EMBO JOURNAL

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

(2008) Sylvie Thuault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity

(2008) C. Gamell et al.   JOURNAL OF CELL SCIENCE

L- and S-endoglin differentially modulate TGF 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

(2008) S. Velasco et al.   JOURNAL OF CELL SCIENCE

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Specific Activation of Mitogen-activated Protein Kinase by Transforming Growth Factor-β Receptors in Lipid Rafts Is Required for Epithelial Cell Plasticity

(2008) Wei Zuo et al.   MOLECULAR BIOLOGY OF THE CELL

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY