Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

(2010) Xiu Jun Wang et al.   CHEMISTRY & BIOLOGY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration

(2010) N. Wakabayashi et al.   Science Signaling

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition

(2009) Fränzel JB van Duijnhoven et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

(2009) Aimee L. Eggler et al.   BIOCHEMICAL JOURNAL

Inhibition of Activator Protein-1 by Sulforaphane Involves Interaction with Cysteine in the cFos DNA-Binding Domain: Implications for Chemoprevention of UVB-Induced Skin Cancer

(2009) S. E. Dickinson et al.   CANCER RESEARCH

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic  , -unsaturated aldehyde acrolein

(2009) M. O. Kelleher et al.   CARCINOGENESIS

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Hydrogen Peroxide Is a Second Messenger in Phase 2 Enzyme Induction by Cancer Chemopreventive Dithiolethiones

(2009) Ryan Holland et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The role of c-Jun phosphorylation in EpRE activation of phase II genes

(2009) Smadar Levy et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cell cycle is a redox cycle: Linking phase-specific targets to cell fate

(2009) William C. Burhans et al.   FREE RADICAL BIOLOGY AND MEDICINE

A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes

(2009) Julia Li Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isothiocyanates, glutathioneS-transferase M1 and T1 polymorphisms and gastric cancer risk: A prospective study of men in Shanghai, China

(2009) Kristin A. Moy et al.   INTERNATIONAL JOURNAL OF CANCER

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Alternative DNA Recognition by Maf Transcription Factors

(2009) H. Kurokawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacologic inhibitors of I B kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo

(2009) A. I. Idris et al.   MOLECULAR CANCER THERAPEUTICS

The Guardian Recruits Cops: The p53-p21 Axis Delegates Prosurvival Duties to the Keap1-Nrf2 Stress Pathway

(2009) Michel B. Toledano   MOLECULAR CELL

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

(2009) A. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure

(2009) Karen F. Chambers et al.   PROSTATE

Protection against Aflatoxin B1 in Rat—A New Look at the Link between Toxicity, Carcinogenicity, and Metabolism

(2009) Elizabeth M. Ellis   TOXICOLOGICAL SCIENCES

Transgenic Expression of Aflatoxin Aldehyde Reductase (AKR7A1) Modulates Aflatoxin B1 Metabolism but not Hepatic Carcinogenesis in the Rat

(2009) Bill D. Roebuck et al.   TOXICOLOGICAL SCIENCES

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1

(2009) Zoran Ilic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

(2008) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

(2008) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk

(2008) L. Tang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Urinary Total Isothiocyanates and Colorectal Cancer: A Prospective Study of Men in Shanghai, China

(2008) K. A. Moy et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Multitargeted cancer prevention by quercetin

(2008) Akira Murakami et al.   CANCER LETTERS

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

(2008) Yulun Huang et al.   CANCER LETTERS

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts

(2008) R. Munday et al.   CANCER RESEARCH

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

(2008) K. Liby et al.   CANCER RESEARCH

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway

(2008) S. L. Brown et al.   CANCER RESEARCH

RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

(2008) A. Singh et al.   CANCER RESEARCH

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protection Against Aflatoxin B1-Induced Cytotoxicity by Expression of the Cloned Aflatoxin B1-Aldehyde Reductases Rat AKR7A1 and Human AKR7A3

(2008) Sridevi Bodreddigari et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Prevention and Treatment of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268

(2008) K. Liby et al.   CLINICAL CANCER RESEARCH

Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice

(2008) Ying Ji Li et al.   CLINICAL IMMUNOLOGY

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

(2008) Marc A. Riedl et al.   CLINICAL IMMUNOLOGY

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

(2008) John D. Hayes et al.   EUROPEAN JOURNAL OF NUTRITION

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

(2008) Anju Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element

(2008) Ibrul Chowdhury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts

(2008) Harumi Harada et al.   FREE RADICAL RESEARCH

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

(2008) Ian M. Copple et al.   HEPATOLOGY

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

(2008) Yiguo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

(2008) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

(2008) K. Liby et al.   MOLECULAR CANCER THERAPEUTICS

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

(2008) N M Reddy et al.   ONCOGENE

The in vivo gene expression signature of oxidative stress

(2008) Eun-Soo Han et al.   PHYSIOLOGICAL GENOMICS

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid

(2008) Freddie R. Salsbury et al.   PROTEIN SCIENCE

Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice

(2008) William O. Osburn et al.   TOXICOLOGICAL SCIENCES

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

(2007) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY