4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway

IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

(2020) Zhongjie Yi et al.   HEPATOLOGY

Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

(2020) Daniel Richard et al.   CELL

Sema4D Aggravated LPS-Induced Injury via Activation of the MAPK Signaling Pathway in ATDC5 Chondrocytes

(2020) Jinlai Lei et al.   Biomed Research International

LPS ‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice

(2020) Melanie E Mendez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes

(2020) Feng Gao et al.   Drug Design Development and Therapy

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

(2020) Haoyu Song et al.   EBioMedicine

Hyperoside ameliorates the progression of osteoarthritis: an in vitro and in vivo study

(2020) Kai Sun et al.   PHYTOMEDICINE

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS‐treated mouse chondrocytes and osteoarthritis model

(2019) Yang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Salidroside protects ATDC5 cells against lipopolysaccharide-induced injury through up-regulation of microRNA-145 in osteoarthritis

(2019) Meihan Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MicroRNA-26a reduces synovial inflammation and cartilage injury in osteoarthritis of knee joints through impairing the NF-κB signaling pathway

(2019) Zhi Zhao et al.   BIOSCIENCE REPORTS

Octyl-itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling

(2019) Xuewu Sun et al.   FASEB JOURNAL

Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis

(2019) Qingbai Liu et al.   GENE

Role of Inflammation and the Immune System in the Progression of Osteoarthritis

(2019) Jennifer E. Woodell‐May et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Labisia pumila prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model

(2018) Iffah Nadhira Madzuki et al.   INFLAMMOPHARMACOLOGY

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Reactive oxygen species, aging and articular cartilage homeostasis

(2018) Jesalyn A. Bolduc et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system

(2018) Luca Perico et al.   KIDNEY INTERNATIONAL

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose

(2018) Chun Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

(2018) Hua Liu et al.   Cell Communication and Signaling

Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice

(2017) Zheng Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

(2017) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemokines and inflammation in osteoarthritis: Insights from patients and animal models

(2017) Carla R. Scanzello   JOURNAL OF ORTHOPAEDIC RESEARCH

Regenerative approaches for cartilage repair in the treatment of osteoarthritis

(2017) M.H. Li et al.   OSTEOARTHRITIS AND CARTILAGE

LPS promotes resistance to TRAIL-induced apoptosis in pancreatic cancer

(2017) Katharina Beyer et al.   Infectious Agents and Cancer

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?

(2016) Christine A. Houghton et al.   Oxidative Medicine and Cellular Longevity

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Cytoprotective effects of 12-oxo phytodienoic acid, a plant-derived oxylipin jasmonate, on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells

(2014) Nozomi Taki-Nakano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulatory Roles of Metabolites in Cell Signaling Networks

(2013) Feng Li et al.   Journal of Genetics and Genomics

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knee replacement

(2012) Andrew J Carr et al.   LANCET

Abbott boosts investment in NRF2 activators for reducing oxidative stress

(2012) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity

(2009) X. H. Bai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor

(2009) X.-H. Bai et al.   MOLECULAR AND CELLULAR BIOLOGY

A systems biology perspective on Nrf2-mediated antioxidant response

(2009) Qiang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of intraarticular ropivacaine and morphine on lipopolysaccharide‐induced synovitis in horses

(2009) Luiz César Pereira Santos et al.   VETERINARY ANAESTHESIA AND ANALGESIA

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS