Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

TIPE2 Alleviates Systemic Lupus Erythematosus Through Regulating Macrophage Polarization

(2016) Feng Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

(2015) C. I. Caescu et al.   BLOOD

Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway

(2015) N. Jethwa et al.   JOURNAL OF CELL SCIENCE

TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer

(2014) Svetlana A. Fayngerts et al.   CANCER CELL

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

TIPE2 Negatively Regulates Inflammation by Switching Arginine Metabolism from Nitric Oxide Synthase to Arginase

(2014) Yunwei Lou et al.   PLoS One

Macrophage: SHIP of Immunity

(2014) Charles D. Mills et al.   Frontiers in Immunology

SOCS Proteins in Macrophage Polarization and Function

(2014) Heather M. Wilson   Frontiers in Immunology

Akt1-Mediated Regulation of Macrophage Polarization in a Murine Model of Staphylococcus aureus Pulmonary Infection

(2013) Feng Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways

(2013) Feng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Macrophage polarization and plasticity in health and disease

(2012) Subhra K. Biswas et al.   IMMUNOLOGIC RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway

(2012) H. Sun et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras

(2012) Yael Gus-Brautbar et al.   MOLECULAR CELL

TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways

(2011) Liping Sun et al.   EXPERIMENTAL CELL RESEARCH

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

(2011) Qingguo Ruan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Polarization in Health and Disease

(2011) Luca Cassetta et al.   TheScientificWorldJOURNAL

Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy

(2011) Valentina Marchetti et al.   Scientific Reports

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Tissue-specific expression of TIPE2 provides insights into its function

(2010) Guizhong Zhang et al.   MOLECULAR IMMUNOLOGY

Orchestration of macrophage polarization

(2009) A. Mantovani et al.   BLOOD

TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

(2008) Honghong Sun et al.   CELL

RalGDS Couples Growth Factor Signaling to Akt Activation

(2008) Y. Hao et al.   MOLECULAR AND CELLULAR BIOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark