TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering

(2014) Limin Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: A cross-sectional study

(2014) C. Ballegaard et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis

(2014) Gehua Zhen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Induction of an Inflammatory and Prodegradative Phenotype in Autologous Fibroblast-like Synoviocytes by the Infrapatellar Fat Pad From Patients With Knee Osteoarthritis

(2014) Florent Eymard et al.   Arthritis & Rheumatology

Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1

(2014) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Toll-like receptors in human chondrocytes and osteoarthritic cartilage

(2013) Tarvo Sillat et al.   Acta Orthopaedica

Adult Cartilage-Specific Peroxisome Proliferator–Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype

(2013) Faezeh Vasheghani et al.   AMERICAN JOURNAL OF PATHOLOGY

Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4–MyD88 dissociation

(2013) Juna Nakao et al.   BONE

Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage

(2013) Amanda Villalvilla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of TLR4 Signaling by TRAM-Derived Decoy Peptides In Vitro and In Vivo

(2013) W. Piao et al.   JOURNAL OF IMMUNOLOGY

EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee

(2013) Ying Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes

(2013) Rodolfo Gómez et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

6-Shogaol inhibits chondrocytes’ innate immune responses and cathepsin-K activity

(2013) Amanda Villalvilla et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Osteoporotic OA: a reasonable target for bone-acting agents

(2013) Gabriel Herrero-Beaumont et al.   Nature Reviews Rheumatology

Oral and topical boswellic acid attenuates mouse osteoarthritis

(2013) Q. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced Glycation End Products Induce Peroxisome Proliferator-Activated Receptor γ Down-Regulation-Related Inflammatory Signals in Human Chondrocytes via Toll-Like Receptor-4 and Receptor for Advanced Glycation End Products

(2013) Ying Ju Chen et al.   PLoS One

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

(2013) Matthew D. Neal et al.   PLoS One

Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties

(2013) Dominique de Seny et al.   PLoS One

LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NF-κB and BMP/Smad Signaling

(2013) Ru-Lin Huang et al.   STEM CELLS AND DEVELOPMENT

A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts

(2013) Anqi Gao et al.   PeerJ

Cherry consumption and decreased risk of recurrent gout attacks

(2012) Yuqing Zhang et al.   ARTHRITIS AND RHEUMATISM

Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes

(2012) Giuseppe M. Campo et al.   BIOFACTORS

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β

(2012) Giuseppe M. Campo et al.   FEBS Journal

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

(2012) Michael Luong et al.   Journal of Inflammation-London

The stimulation of adenosine 2A receptor reduces inflammatory response in mouse articular chondrocytes treated with hyaluronan oligosaccharides

(2012) Giuseppe M. Campo et al.   MATRIX BIOLOGY

Relationship between cartilage and subchondral bone lesions in repetitive impact trauma-induced equine osteoarthritis

(2012) M. Lacourt et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammation and Toll-Like Receptor Ligation Differentially Affect the Osteogenic Potential of Human Mesenchymal Stromal Cells Depending on Their Tissue Origin

(2012) Gordana Raicevic et al.   TISSUE ENGINEERING PART A

Plasma proteins take their toll on the joint in osteoarthritis

(2012) Steven R Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes

(2011) J. Conde et al.   ANNALS OF THE RHEUMATIC DISEASES

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

(2011) I. R. Klein-Wieringa et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor

(2011) Nidhi Sofat et al.   Journal of Innate Immunity

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

What's new in our understanding of the role of adipokines in rheumatic diseases?

(2011) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis

(2011) M. Bellido et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoporotic changes of subchondral trabecular bone in osteoarthritis of the knee: a 3-T MRI study

(2011) K. Chiba et al.   OSTEOPOROSIS INTERNATIONAL

Interleukin-6 Synthesis in Human Chondrocytes Is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2

(2011) Pu Wang et al.   PLoS One

Different dimerisation mode for TLR4 upon endosomal acidification?

(2011) Monique Gangloff   TRENDS IN BIOCHEMICAL SCIENCES

Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium

(2011) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS RESEARCH & THERAPY

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

Exploring the Human Leukocyte Phosphoproteome Using a Microfluidic Reversed-Phase−TiO2−Reversed-Phase High-Performance Liquid Chromatography Phosphochip Coupled to a Quadrupole Time-of-Flight Mass Spectrometer

(2010) Reinout Raijmakers et al.   ANALYTICAL CHEMISTRY

Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line

(2010) Anna Iacono et al.   ARTHRITIS AND RHEUMATISM

Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation

(2010) Kenjiro Bandow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes

(2010) Giuseppe M. Campo et al.   BIOCHEMICAL PHARMACOLOGY

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets

(2010) Matteo Piazza et al.   Innate Immunity

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells

(2010) H. Tsukamoto et al.   INTERNATIONAL IMMUNOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity

(2010) M.R. Hutchinson et al.   NEUROSCIENCE

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis

(2010) C. Karlsson et al.   OSTEOARTHRITIS AND CARTILAGE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ in bone homeostasis

(2010) Yihong Wan   TRENDS IN ENDOCRINOLOGY AND METABOLISM

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

Local Interleukin-1-Driven Joint Pathology Is Dependent on Toll-Like Receptor 4 Activation

(2009) Shahla Abdollahi-Roodsaz et al.   AMERICAN JOURNAL OF PATHOLOGY

Denuded subchondral bone and knee pain in persons with knee osteoarthritis

(2009) Kirsten Moisio et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin-6 and its soluble receptor

(2009) Emilie Distel et al.   ARTHRITIS AND RHEUMATISM

Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors

(2009) Yang Soon Kim et al.   BONE

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-α in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice

(2009) Young Ok Jung et al.   IMMUNOLOGY LETTERS

Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-α production via down-regulation of MyD88 expression

(2009) Abu Shadat M. Noman et al.   Innate Immunity

Analysing the role of endogenous matrix molecules in the development of osteoarthritis

(2009) Nidhi Sofat   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Molecular Mechanism of the Bifunctional Role of Lipopolysaccharide in Osteoclastogenesis

(2009) Jianzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol

(2009) Sang-Il Ahn et al.   MOLECULES AND CELLS

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Hand osteoarthritis in Chuvashian population: prevalence and determinants

(2009) Leonid Kalichman et al.   RHEUMATOLOGY INTERNATIONAL

How Location Governs Toll-Like Receptor Signaling

(2009) Akanksha Chaturvedi et al.   TRAFFIC

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Characterization of metalloprotease cleavage products of human articular cartilage

(2008) Eugene Y. Zhen et al.   ARTHRITIS AND RHEUMATISM

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

(2008) Natsuko Tanimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prostaglandin D2 Receptors DP and CRTH2 in the Pathogenesis of Asthma

(2008) Masafumi Arima et al.   CURRENT MOLECULAR MEDICINE

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Expression of functional Toll-like receptors and nucleotide-binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiation

(2008) E. Nemoto et al.   JOURNAL OF PERIODONTAL RESEARCH

Heat shock protein–antigen fusions lose their enhanced immunostimulatory capacity after endotoxin depletion

(2008) Boris-Christian Marincek et al.   MOLECULAR IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis

(2008) M.A. Álvarez-Soria et al.   OSTEOARTHRITIS AND CARTILAGE

Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage

(2007) Lisbet Haglund et al.   MATRIX BIOLOGY