- Home
- Publications
- Publication Search
- Publication Details
Title
Melatonin: A novel candidate for the treatment of osteoarthritis
Authors
Keywords
Osteoarthritis, Melatonin, Inflammation, Matrix metabolism, Redox balance
Journal
AGEING RESEARCH REVIEWS
Volume 78, Issue -, Pages 101635
Publisher
Elsevier BV
Online
2022-04-26
DOI
10.1016/j.arr.2022.101635
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intra-articular Injections of Mesenchymal Stem Cells Without Adjuvant Therapies for Knee Osteoarthritis: A Systematic Review and Meta-analysis
- (2021) Si Heng Sharon Tan et al. AMERICAN JOURNAL OF SPORTS MEDICINE
- Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway
- (2021) Tian-Yu Feng et al. Oxidative Medicine and Cellular Longevity
- Diagnosis and Treatment of Hip and Knee Osteoarthritis
- (2021) Jeffrey N. Katz et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway
- (2021) Mingjun Cao et al. JOURNAL OF PINEAL RESEARCH
- Oxidative stress-induced DNA damage and repair in primary human osteoarthritis chondrocytes: focus on IKKα and the DNA Mismatch Repair System
- (2021) Simona Neri et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
- (2021) John A. Collins et al. FREE RADICAL BIOLOGY AND MEDICINE
- Melatonin and Cardioprotection in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- (2021) Alberto Domínguez-Rodríguez et al. Frontiers in Cardiovascular Medicine
- Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials
- (2021) Tom GH Wiggers et al. BRITISH JOURNAL OF SPORTS MEDICINE
- The potential remedy of melatonin on osteoarthritis
- (2021) Ko‐Hsiu Lu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin Maintains Anabolic-Catabolic Equilibrium and Regulates Circadian Rhythm During Osteoarthritis Development in Animal Models: A Systematic Review and Meta-analysis
- (2021) Dewan Md. Sumsuzzman et al. Frontiers in Pharmacology
- Molecular Classification of Knee Osteoarthritis
- (2021) Zhongyang Lv et al. Frontiers in Cell and Developmental Biology
- Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis
- (2021) Liam D. A. Paget et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
- (2021) Ying Han et al. Bioactive Materials
- Melatonin up‐regulates bone marrow mesenchymal stem cells osteogenic action but suppresses their mediated osteoclastogenesis via MT 2 ‐inactivated NF‐κB pathway
- (2020) Yi Zhou et al. BRITISH JOURNAL OF PHARMACOLOGY
- FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis
- (2020) Kwang Il Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The systemic role of SIRT1 in exercise mediated adaptation
- (2020) Zsolt Radak et al. Redox Biology
- Metformin limits osteoarthritis development and progression through activation of AMPK signalling
- (2020) Jun Li et al. ANNALS OF THE RHEUMATIC DISEASES
- The Effect of Melatonin Supplementation on Liver Indices in Patients with Non-Alcoholic Fatty Liver Disease: a systematic review and meta-analysis of randomized clinical trials
- (2020) Anahita Mansoori et al. COMPLEMENTARY THERAPIES IN MEDICINE
- Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration
- (2020) Abhishek Jauhari et al. JOURNAL OF CLINICAL INVESTIGATION
- Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway
- (2020) Yue Xu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway
- (2020) Yazhong Zhang et al. CALCIFIED TISSUE INTERNATIONAL
- Melatonin ameliorates PM 2.5 ‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis
- (2020) Jinjin Jiang et al. JOURNAL OF PINEAL RESEARCH
- Electrospun nanofibers for the delivery of active drugs through nasal, oral and vaginal mucosa: Current status and future perspectives
- (2020) Hasham S. Sofi et al. Materials Science & Engineering C-Materials for Biological Applications
- Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/ HO ‐1 and SIRT ‐1/ FOXO ‐1 expressions
- (2020) Jitendra Kumar et al. ENVIRONMENTAL TOXICOLOGY
- Medicinal plants used in wound dressings made of electrospun nanofibers
- (2020) Parichehr Fatehi et al. Journal of Tissue Engineering and Regenerative Medicine
- Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies
- (2020) Monireh Kouhi et al. Materials Science & Engineering C-Materials for Biological Applications
- The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration
- (2020) Zhi Peng et al. BIOMATERIALS
- Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
- (2020) Philip R. Coryell et al. Nature Reviews Rheumatology
- Melatonin: Another avenue for treating osteoporosis?
- (2019) Tian Li et al. JOURNAL OF PINEAL RESEARCH
- Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis
- (2019) Chien-Chung Huang et al. JOURNAL OF PINEAL RESEARCH
- Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
- (2019) Song Ho Chang et al. Nature Communications
- Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression
- (2019) Gabriel Herrero-Beaumont et al. BIOCHEMICAL PHARMACOLOGY
- Structural basis of ligand recognition at the human MT1 melatonin receptor
- (2019) Benjamin Stauch et al. NATURE
- Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin
- (2019) Masaki Nakano et al. JOURNAL OF ENDOCRINOLOGY
- Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation
- (2019) Yan Zhang et al. Aging-US
- Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties
- (2019) Weikai Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Injectable PNIPAM/Hyaluronic acid hydrogels containing multipurpose modified particles for cartilage tissue engineering: Synthesis, characterization, drug release and cell culture study
- (2019) Zhaleh Atoufi et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Molecular recognition-directed site-specific release of stem cell differentiation inducers for enhanced joint repair
- (2019) Xuemin Liu et al. BIOMATERIALS
- Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages
- (2019) Yue Hu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Melatonin enhances mitochondrial biogenesis and protects against rotenone‐induced mitochondrial deficiency in early porcine embryos
- (2019) Ying‐Jie Niu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140
- (2019) Yijian Zhang et al. Oxidative Medicine and Cellular Longevity
- Nrf2 as a therapeutic target for rheumatic diseases
- (2018) María Luisa Ferrándiz et al. BIOCHEMICAL PHARMACOLOGY
- Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis
- (2018) Nazir M. Khan et al. FREE RADICAL BIOLOGY AND MEDICINE
- 3D melatonin nerve scaffold reduces oxidative stress, inflammation and increases autophagy in peripheral nerve regeneration
- (2018) Yun Qian et al. JOURNAL OF PINEAL RESEARCH
- Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
- (2018) Annia Galano et al. JOURNAL OF PINEAL RESEARCH
- Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells
- (2018) Zizhao Wu et al. JOURNAL OF PINEAL RESEARCH
- NLRP3 as a potentially novel biomarker for the management of osteoarthritis
- (2018) M.J. McAllister et al. OSTEOARTHRITIS AND CARTILAGE
- Sirtuin activators and inhibitors: Promises, achievements, and challenges
- (2018) Han Dai et al. PHARMACOLOGY & THERAPEUTICS
- Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells
- (2018) Bo Gao et al. Stem Cell Research & Therapy
- Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
- (2018) K. Nishida et al. Bone & Joint Research
- Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism
- (2018) Ming Shen et al. Redox Biology
- Graft Hypertrophy After Third-Generation Autologous Chondrocyte Implantation Has No Correlation With Reduced Cartilage Quality: Matched-Pair Analysis Using T2-Weighted Mapping
- (2018) Thomas R. Niethammer et al. AMERICAN JOURNAL OF SPORTS MEDICINE
- NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
- (2018) C Guo et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Reactive oxygen species, aging and articular cartilage homeostasis
- (2018) Jesalyn A. Bolduc et al. FREE RADICAL BIOLOGY AND MEDICINE
- Redox and NF-κB signaling in osteoarthritis
- (2018) Panagiotis Lepetsos et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?
- (2018) M. H. J. van den Bosch CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway
- (2018) Zengjie Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Modified In Vitro Release of Melatonin Loaded in Nanofibrous Electrospun Mats Incorporated Into Monolayered and Three-Layered Tablets
- (2018) Marilena Vlachou et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- The changing role of TGFβ in healthy, ageing and osteoarthritic joints
- (2017) Peter M. van der Kraan Nature Reviews Rheumatology
- Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice
- (2017) Q. Wang et al. OSTEOARTHRITIS AND CARTILAGE
- Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS
- (2017) L. Zhou et al. OSTEOPOROSIS INTERNATIONAL
- FOXO Transcriptional Factors and Long-Term Living
- (2017) Ghulam Murtaza et al. Oxidative Medicine and Cellular Longevity
- Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD + -dependent SIRT1
- (2017) Wei Yang et al. STEROIDS
- Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
- (2017) Jia Yi Guo et al. Oncotarget
- Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee
- (2017) Yunkyung Hong et al. Oncotarget
- ROS/oxidative stress signaling in osteoarthritis
- (2016) Panagiotis Lepetsos et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells
- (2016) Ikuko Hosokawa et al. INFLAMMATION
- Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease
- (2016) Yuan-Yuan Wang et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad
- (2016) Konrad Kleszczyński et al. JOURNAL OF PINEAL RESEARCH
- Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome
- (2016) Yong Zhang et al. JOURNAL OF PINEAL RESEARCH
- Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis
- (2016) R.E. Miller et al. OSTEOARTHRITIS AND CARTILAGE
- The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity
- (2016) Yusheng Li et al. Journal of Orthopaedic Surgery and Research
- Melatonin in functionalized biomimetic constructs promotes rapid tissue regeneration in Wistar albino rats
- (2016) Ragothaman Murali et al. Journal of Materials Chemistry B
- Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis
- (2016) Yao Fu et al. Arthritis & Rheumatology
- Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
- (2015) Giuseppe Musumeci et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α
- (2015) Wuyin Li et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial
- (2015) Anne Kristine Amstrup et al. JOURNAL OF PINEAL RESEARCH
- Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
- (2015) K. Nagai et al. OSTEOARTHRITIS AND CARTILAGE
- Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis
- (2015) Dawei Cai et al. ARTHRITIS RESEARCH & THERAPY
- Interleukin-1βModulates Melatonin Secretion in Ovine Pineal Gland:Ex VivoStudy
- (2015) A. P. Herman et al. Biomed Research International
- Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis
- (2014) Jin-Hong Kim et al. CELL
- A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration
- (2014) Ying Zhang et al. CELL AND TISSUE RESEARCH
- Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells
- (2014) Constanze Buhrmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Melatonin regulates mesenchymal stem cell differentiation: a review
- (2014) Francesca Luchetti et al. JOURNAL OF PINEAL RESEARCH
- Salutary effects of melatonin combined with treadmill exercise on cartilage damage
- (2014) Yunkyung Hong et al. JOURNAL OF PINEAL RESEARCH
- Premedication with Oral Alprazolam and Melatonin Combination: A Comparison with Either Alone—A Randomized Controlled Factorial Trial
- (2014) Krishna Pokharel et al. Biomed Research International
- Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- (2013) Tokio Matsuzaki et al. ANNALS OF THE RHEUMATIC DISEASES
- Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints
- (2013) Daniel Prieto-Alhambra et al. ANNALS OF THE RHEUMATIC DISEASES
- Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases
- (2013) Xiaozhen Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sirt1-deficient mice exhibit an altered cartilage phenotype
- (2013) Odile Gabay et al. JOINT BONE SPINE
- Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development
- (2013) Hiroshi Kobayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells
- (2013) Xiaozhen Liu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells
- (2013) Wenjie Gao et al. JOURNAL OF PINEAL RESEARCH
- Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
- (2013) Gehua Zhen et al. NATURE MEDICINE
- Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis
- (2013) Y. Akasaki et al. OSTEOARTHRITIS AND CARTILAGE
- MMP13 is a critical target gene during the progression of osteoarthritis
- (2013) Meina Wang et al. ARTHRITIS RESEARCH & THERAPY
- Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
- (2012) Odile Gabay et al. ANNALS OF THE RHEUMATIC DISEASES
- Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2
- (2012) Christos Gavriilidis et al. ARTHRITIS AND RHEUMATISM
- Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling
- (2012) Dingbo Shi et al. JOURNAL OF PINEAL RESEARCH
- Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway
- (2012) Hyun-Dae Lim et al. JOURNAL OF PINEAL RESEARCH
- Inhibition of p38 pathway leads to OA-like changes in a rat animal model
- (2012) I. Prasadam et al. RHEUMATOLOGY
- Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice
- (2011) Amartya Mishra et al. BIOCHIMIE
- Age-dependent alteration of TGF-β signalling in osteoarthritis
- (2011) Peter M. van der Kraan et al. CELL AND TISSUE RESEARCH
- Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women
- (2011) Mary P. Kotlarczyk et al. JOURNAL OF PINEAL RESEARCH
- Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
- (2010) J. L. Scott et al. ANNALS OF THE RHEUMATIC DISEASES
- Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti
- (2010) Steven Settle et al. ARTHRITIS AND RHEUMATISM
- Reactive Oxygen Species Generated by NADPH Oxidase 2 and 4 Are Required for Chondrogenic Differentiation
- (2010) Ki Soon Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of the cartilage matrix in osteoarthritis
- (2010) Dick Heinegård et al. Nature Reviews Rheumatology
- TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis
- (2009) P.M. van der Kraan et al. OSTEOARTHRITIS AND CARTILAGE
- MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
- (2009) B.-C. Sondergaard et al. OSTEOARTHRITIS AND CARTILAGE
- Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes
- (2009) J. Kim et al. OSTEOARTHRITIS AND CARTILAGE
- Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
- (2009) Y. Nakahata et al. SCIENCE
- Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications: In Vitro Studies and Preliminary In Vivo Evaluation
- (2009) João T. Oliveira et al. TISSUE ENGINEERING PART A
- Cartilage homeostasis in health and rheumatic diseases
- (2009) Mary B Goldring et al. ARTHRITIS RESEARCH & THERAPY
- P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis
- (2008) Kimberly K Brown et al. Journal of Inflammation-London
- Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
- (2008) Ming Pei et al. JOURNAL OF PINEAL RESEARCH
- Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(−) in adult bovine articular cartilage
- (2008) I.M. Khan et al. OSTEOARTHRITIS AND CARTILAGE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now