Macrophage plasticity and polarization in tissue repair and remodelling

Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes

(2012) F. Guilloton et al.   BLOOD

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells

(2012) Shigeki Ohta et al.   JOURNAL OF CELL SCIENCE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients

(2012) C. Bergenfelz et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

(2012) Hideaki Nakajima et al.   JOURNAL OF NEUROTRAUMA

Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion

(2012) Kevin Anton et al.   PLoS One

Tumor Associated Macrophage × Cancer Cell Hybrids May Acquire Cancer Stem Cell Properties in Breast Cancer

(2012) Jingxian Ding et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells

(2011) H. Okuda et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Macrophage heterogeneity and acute inflammation

(2011) Kate Liddiard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages

(2011) Senthil Palani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF- -Mediated Bone Loss

(2011) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Two Unique Human Decidual Macrophage Populations

(2011) B. L. Houser et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Macrophage Differentiation and Polarization via Phosphatidylinositol 3-Kinase/Akt-ERK Signaling Pathway Conferred by Serum Amyloid P Component

(2011) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Macrophages at the Fetal-Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10

(2011) J. Svensson et al.   JOURNAL OF IMMUNOLOGY

Macrophages in Allergic Asthma: Fine-Tuning Their Pro- and Anti-Inflammatory Actions for Disease Resolution

(2011) Ana Paula Moreira et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro

(2011) W. R. Winnall et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes

(2011) Fahd Al-Mulla et al.   Molecular BioSystems

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype

(2011) Gaetano Cairo et al.   TRENDS IN IMMUNOLOGY

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

(2010) Jenean O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

The Contribution of Macrophages to Normal and Pathological Pregnancies

(2010) Takeshi Nagamatsu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

(2010) O. Klimchenko et al.   BLOOD

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment

(2010) A. J. Clear et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1

(2010) Marco Erreni et al.   EUROPEAN JOURNAL OF CANCER

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Polarization dictates iron handling by inflammatory and alternatively activated macrophages

(2010) G. Corna et al.   HAEMATOLOGICA

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections

(2010) Chris A Mares et al.   IMMUNOLOGY AND CELL BIOLOGY

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P

(2010) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

M2b Monocytes Predominated in Peripheral Blood of Severely Burned Patients

(2010) M. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer

(2010) Federica Marchesi et al.   JOURNAL OF NEUROIMMUNOLOGY

Bridges that guide and unite

(2010) Thomas Schmidt et al.   NATURE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

The many paths to asthma: phenotype shaped by innate and adaptive immunity

(2010) Hye Young Kim et al.   NATURE IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages

(2010) Lynne A. Murray et al.   PLoS One

Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression

(2010) P. Vacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

(2010) F. Bellora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Regulation of macrophage function in tumors: the multifaceted role of NF- B

(2009) T. Hagemann et al.   BLOOD

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction

(2009) C. Troidl et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways

(2009) Karine Lolmede et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

ORIGINAL ARTICLE: Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells

(2008) Gordana Laškarin et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

From phagocyte diversity and activation to probiotics: Back to Metchnikoff

(2008) Alberto Mantovani   EUROPEAN JOURNAL OF IMMUNOLOGY

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Macrophage roles following myocardial infarction

(2008) Jessica M. Lambert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

First responders: understanding monocyte-lineage traffic in the acutely injured kidney

(2008) Sundararaman Swaminathan et al.   KIDNEY INTERNATIONAL

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype

(2008) Charlotte Gustafsson et al.   PLoS One