Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling

Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis

(2019) Bing Wei et al.   DRUG DEVELOPMENT RESEARCH

Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model

(2019) Kai Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

(2019) Yan Zu et al.   Journal of Orthopaedic Surgery and Research

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

(2018) Linan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

(2018) Bowie Y. Cheng et al.   CANCER RESEARCH

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

(2018) M.J. McAllister et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

(2018) Jack W. Singer et al.   Oncotarget

Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3

(2017) Yufeng Sun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Quercetin and the mitochondria: A mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

(2016) Lin-Lin Kang et al.   Scientific Reports

Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes

(2015) Sheng-nan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

(2015) Zhen Ning Wee et al.   Nature Communications

Future nanomedicine for the diagnosis and treatment of osteoarthritis

(2014) Lauren R Eichaker et al.   Nanomedicine

The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli

(2014) B. Steinecker-Frohnwieser et al.   OSTEOARTHRITIS AND CARTILAGE

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

Diagnosis and Treatment of Osteoarthritis

(2013) Rafaelani L. Taruc-Uy et al.   PRIMARY CARE

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delphinidin inhibits IL-1 -induced activation of NF- B by modulating the phosphorylation of IRAK-1Ser376 in human articular chondrocytes

(2013) A. Haseeb et al.   RHEUMATOLOGY

TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro

(2012) Jun Qin et al.   ARTHRITIS RESEARCH & THERAPY

Pharmaceutical Therapy for Osteoarthritis

(2012) David S. Cheng et al.   PM&R

Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis

(2011) Mehmet Kanter et al.   FOOD AND CHEMICAL TOXICOLOGY