Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation

(2022) Consuelo Arias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Phenolic Content, Antioxidative Properties and Extractable Substances in Silver Fir (Abies alba Mill.) Branches Decrease with Distance from the Trunk

(2022) Katja Schoss et al.   Plants-Basel

Intra-articular Injection of (-)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis

(2021) Hsuan-Ti Huang et al.   Antioxidants

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

(2021) Qichan Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin suppresses apoptosis of chondrocytes induced by IL‑1β via inactivation of p38 MAPK signaling pathway

(2021) Xiang-Peng Wang et al.   Experimental and Therapeutic Medicine

Immunomodulatory Effects of Dietary Polyphenols

(2021) Hira Shakoor et al.   Nutrients

MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling

(2021) Wei Zhang et al.   BMC Geriatrics

A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators

(2021) Mehmet Yabas et al.   Frontiers in Immunology

Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies

(2021) Evdokia Valsamidou et al.   Nutrients

The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

(2021) Xiaobin Shang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

(2021) Javad Sharifi-Rad et al.   Oxidative Medicine and Cellular Longevity

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

(2021) Yoshiaki Ito et al.   Nature Communications

Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model

(2021) Akihiro Nakahata et al.   Cartilage

Comprehensive Analysis of Key Genes, Signaling Pathways and miRNAs in Human Knee Osteoarthritis: Based on Bioinformatics

(2021) Liang Chang et al.   Frontiers in Pharmacology

Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1β through blocking the NF-κB/HIF-2α signaling pathway

(2021) Pengzhen Wang et al.   Annals of Translational Medicine

Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling

(2021) Wenjun Li et al.   Journal of Inflammation Research

Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a

(2021) Jiayu Yao et al.   Journal of Inflammation Research

Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology

(2021) Zhiyong Long et al.   Evidence-based Complementary and Alternative Medicine

Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study

(2021) Bushra Hassan Marouf   Biomed Research International

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect

(2021) Rui Lu et al.   Frontiers in Pharmacology

Boswellia serrata Extract Containing 30% 3-Acetyl-11-Keto-Boswellic Acid Attenuates Inflammatory Mediators and Preserves Extracellular Matrix in Collagen-Induced Arthritis

(2021) Muhammed Majeed et al.   Frontiers in Physiology

Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis

(2021) Mitra Heydari Nasrabadi et al.   Journal of Ayurveda and Integrative Medicine

Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis

(2020) Li Li et al.   BMC MUSCULOSKELETAL DISORDERS

Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial

(2020) S.M. Heffernan et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

(2020) Manuela Leri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

(2020) Camila R. Ferraz et al.   MOLECULES

Osteoarthritis year in review 2019: epidemiology and therapy

(2020) M. Kloppenburg et al.   OSTEOARTHRITIS AND CARTILAGE

miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1α)

(2020) Fei Yang et al.   MEDICAL SCIENCE MONITOR

Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis

(2020) Dhaneshwar Shep et al.   MEDICINE

Are medical comorbidities contributing to the use of opioid analgesics in patients with knee osteoarthritis?

(2020) L.K. King et al.   OSTEOARTHRITIS AND CARTILAGE

Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells

(2020) Xiaolei Xu et al.   Drug Design Development and Therapy

Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role

(2020) Stefania D’Adamo et al.   Cells

Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis

(2020) Yang Zou et al.   Molecular Medicine Reports

Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations

(2020) Dragan Primorac et al.   Genes

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis

(2020) Zhiqiang Wang et al.   ANNALS OF INTERNAL MEDICINE

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

(2020) Mohammad Yunus Ansari et al.   BIOMEDICINE & PHARMACOTHERAPY

Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair

(2020) Yinji Jin et al.   Materials Science & Engineering C-Materials for Biological Applications

Silver Fir (Abies alba L.) Polyphenolic Extract Shows Beneficial Influence on Chondrogenesis In Vitro under Normal and Inflammatory Conditions

(2020) Mateja Sirše et al.   MOLECULES

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

(2020) Javad Sharifi-Rad et al.   Frontiers in Pharmacology

The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

(2020) Itika Arora et al.   Genes

The Effects of Antioxidant Supplements on the Inflammatory Gene Expression of Osteoarthritis-Like Chondrocytes

(2020) Chen-Ying Su et al.   Applied Sciences-Basel

Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model

(2020) Hsuan-Ti Huang et al.   Antioxidants

Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis

(2019) Bing Wei et al.   DRUG DEVELOPMENT RESEARCH

Blueberries Improve Pain, Gait Performance, and Inflammation in Individuals with Symptomatic Knee Osteoarthritis

(2019) Chen Du et al.   Nutrients

A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee

(2019) Muhammed Majeed et al.   PHYTOTHERAPY RESEARCH

Evaluation of Anti-Inflammatory Activities of a Triterpene β-Elemonic Acid in Frankincense In Vivo and In Vitro

(2019) Yue Zhang et al.   MOLECULES

Anti-inflammatory Action of Blueberry Polyphenols in HIG-82 Rabbit Synoviocytes

(2019) Sanique South et al.   JOURNAL OF MEDICINAL FOOD

Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

(2019) Kai Feng et al.   Oxidative Medicine and Cellular Longevity

Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation

(2019) Feng-Cheng Liu et al.   Nutrients

Rosmarinic acid attenuates inflammation in experimentally induced arthritis in Wistar rats, using Freund’s complete adjuvant

(2019) Rupesh Kumar Gautam et al.   International Journal of Rheumatic Diseases

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

(2019) Hye Eun Lee et al.   MOLECULES

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

(2019) Muhammad Nadeem et al.   Applied Sciences-Basel

Comparative analysis of fresh chondrocytes, cultured chondrocytes and chondroprogenitors derived from human articular cartilage

(2019) Elizabeth Vinod et al.   ACTA HISTOCHEMICA

Polydatin and Resveratrol Inhibit the Inflammatory Process Induced by Urate and Pyrophosphate Crystals in THP-1 Cells

(2019) Francesca Oliviero et al.   Foods

MicroRNA-377–3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6

(2019) Yihui Tu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Effect of Genistein on Condylar Cartilage through Downregulating NF-κB Expression in Experimentally Created Osteoarthritis Rats

(2019) Jian Yuan et al.   Biomed Research International

Green tea ( Camellia sinensis ) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial

(2018) Mohammad Hashem Hashempur et al.   CLINICAL NUTRITION

The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E2 Levels

(2018) Youn-Hwan Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol

(2018) Peter Jörg Rohdewald   JOURNAL OF MEDICINAL FOOD

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis

(2018) Manuela Minguzzi et al.   Oxidative Medicine and Cellular Longevity

The inhibitory effects of rosmarinic acid on catabolism induced by IL-1β in rat chondrocyte

(2018) Zhong-Nan Hu et al.   ACTA BIOCHIMICA POLONICA

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies

(2018) Jie-Hua Chen et al.   Nutrition & Metabolism

Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1β-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5

(2017) Zafar Rasheed et al.   EUROPEAN JOURNAL OF NUTRITION

Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes

(2017) We-Ping Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis

(2017) Jamilah Abusarah et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

(2017) Yulong Wei et al.   Molecular Medicine Reports

Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol®) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial

(2017) Melanie Mülek et al.   Nutrients

Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis

(2017) Jace Schell et al.   Nutrients

Green Tea Extracts Epigallocatechin-3-gallate for Different Treatments

(2017) Chenyu Chu et al.   Biomed Research International

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Roles of microRNA and signaling pathway in osteoarthritis pathogenesis

(2016) Bin Xu et al.   Journal of Zhejiang University-SCIENCE B

Multiplicity of effects and health benefits of resveratrol

(2016) Lolita Kuršvietienė et al.   Medicina-Lithuania

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity

(2016) Carolina I. Ghanem et al.   PHARMACOLOGICAL RESEARCH

Multiplicity of effects and health benefits of resveratrol

(2016) Lolita Kuršvietienė et al.   Medicina-Lithuania

Gingerols and shogaols: Important nutraceutical principles from ginger

(2015) Ruchi Badoni Semwal et al.   PHYTOCHEMISTRY

Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro

(2014) FANG-JIE ZHANG et al.   Experimental and Therapeutic Medicine

Chemical composition of the silver fir (Abies alba) bark extract Abigenol® and its antioxidant activity

(2013) Eva Tavčar Benković et al.   INDUSTRIAL CROPS AND PRODUCTS

Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes

(2013) JUAN XUE et al.   Molecular Medicine Reports

Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro

(2013) Francesca Oliviero et al.   Frontiers in Pharmacology

Dietary polyphenols and mechanisms of osteoarthritis

(2012) Chwan-Li Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Habitual intake of flavonoid subclasses and incident hypertension in adults

(2010) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pycnogenol: A blend of procyanidins with multifaceted therapeutic applications?

(2010) Gabriele D'Andrea   FITOTERAPIA