An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation

(2020) Chao Jiang et al.   CELL STRESS & CHAPERONES

Cardiovascular effects and safety of (non-aspirin) NSAIDs

(2020) Anne-Marie Schjerning et al.   Nature Reviews Cardiology

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

(2019) Xiaoguang Li et al.   Nature Communications

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation

(2019) Raffaele Coppini et al.   Frontiers in Pharmacology

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

(2018) Yunyi Dai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

(2018) Hua Rong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

(2018) Kenji W. Ruiz-Miyazawa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

(2018) Sergio M. Borghi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway

(2018) Wang Wei et al.   NEUROREPORT

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

(2018) Fahad Al-Rashed et al.   Scientific Reports

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

(2018) Jin-Fang Luo et al.   Frontiers in Pharmacology

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

(2017) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells

(2017) Po-Min Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway

(2017) Yan Zhang et al.   REJUVENATION RESEARCH

Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells

(2017) Tiange Li et al.   Nutrients

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

(2017) David Ross et al.   Frontiers in Physiology

Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

(2017) Qinmei Liu et al.   Frontiers in Immunology

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic effect of ent -kaur-16-en-19-oic acid on neutrophilic lung inflammation and sepsis is mediated by Nrf2

(2016) Kyun Ha Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

(2016) Junlian Gu et al.   DIABETES

Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

(2016) Cheng-zhen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Xingkai Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study

(2016) Thangapandiyan Shanmugam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2O2-induced oxidative stress

(2016) Zhe Jian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin

(2016) Anyamanee Chaiprasongsuk et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

(2016) Jinhui Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages

(2016) Ye Won An et al.   NEUROBIOLOGY OF AGING

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice

(2016) Keita Yamauchi et al.   NEUROSCIENCE

An overview on the role of dietary phenolics for the treatment of cancers

(2016) Preethi G. Anantharaju et al.   Nutrition Journal

Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

(2016) Angélica Saraí Jiménez-Osorio et al.   Oxidative Medicine and Cellular Longevity

Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes

(2016) Abraham Said Arellano-Buendía et al.   Oxidative Medicine and Cellular Longevity

Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

(2016) Zhaojun Dong et al.   Oxidative Medicine and Cellular Longevity

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells

(2016) Rattiyaporn Kanlaya et al.   Scientific Reports

Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants

(2015) Megan Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide

(2015) Wonki Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation

(2015) Yanqiu Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Essential Role of NRF2 in Diabetic Wound Healing

(2015) Min Long et al.   DIABETES

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1

(2015) Young Min Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway

(2015) HYUN JUNG KOO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

(2015) Allison J. Greaney et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

(2015) Hiroki Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevation of HO-1 Expression Mitigates Intestinal Ischemia-Reperfusion Injury and Restores Tight Junction Function in a Rat Liver Transplantation Model

(2015) Xinjin Chi et al.   Oxidative Medicine and Cellular Longevity

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

(2015) Shuk-Man Ka et al.   ARTHRITIS RESEARCH & THERAPY

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

(2015) GUANG-FA ZHU et al.   Experimental and Therapeutic Medicine

Casein glycomacropeptide hydrolysate exerts cytoprotection against H2O2-induced oxidative stress in RAW 264.7 macrophages via ROS-dependent heme oxygenase-1 expression

(2015) Xue Cheng et al.   RSC Advances

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

(2014) Liyu He et al.   AMERICAN JOURNAL OF NEPHROLOGY

Myeloid Lineage-Specific Deletion of Antioxidant System Enhances Tumor Metastasis

(2014) K. Hiramoto et al.   Cancer Prevention Research

Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells

(2014) Jhih-Jia Jhang et al.   Cellular & Molecular Immunology

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

(2014) Sarandeep S. S. Boyanapalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Separation and Characterization of Soluble Esterified and Glycoside-Bound Phenolic Compounds in Dry-Blanched Peanut Skins by Liquid Chromatography–Electrospray Ionization Mass Spectrometry

(2014) Yuanyuan Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

(2014) Xiurong Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells

(2014) Young-Jin Jun et al.   MOLECULES

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

Upregulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK–Nrf2 dependent pathway

(2014) Junghun Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages

(2014) Constance Lay Saw et al.   Cell and Bioscience

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

The effect of peroxisome proliferator-activated receptor-  ligands on in vitro and in vivo models of COPD

(2013) S. Lea et al.   EUROPEAN RESPIRATORY JOURNAL

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells

(2012) Assem G. Ziady et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhalation of carbon monoxide reduces skeletal muscle injury after hind limb ischemia-reperfusion injury in mice

(2012) Rajendra Patel et al.   AMERICAN JOURNAL OF SURGERY

Inflammation: Mechanisms, Costs, and Natural Variation

(2012) Noah T. Ashley et al.   Annual Review of Ecology Evolution and Systematics

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats

(2012) Ho-Jae Lee et al.   BMC GASTROENTEROLOGY

Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide

(2012) Tareisha Dunlap et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA

(2012) Ji-Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

(2012) J-H Kim et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Sulforaphane induces SLPI secretion in the nasal mucosa

(2012) Megan Meyer et al.   RESPIRATORY MEDICINE

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Fumaric acid and its esters: An emerging treatment for multiple sclerosis with antioxidative mechanism of action

(2011) R. Gold et al.   CLINICAL IMMUNOLOGY

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo

(2011) Alison C. Brewer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling

(2011) Alba Minelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TNF Mediates the Sustained Activation of Nrf2 in Human Monocytes

(2011) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway

(2011) Narimasa Yoshinaga et al.   LABORATORY INVESTIGATION

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

(2011) Han-Cheon Um et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins

(2011) Christopher C. Leonardo et al.   NUTRITIONAL NEUROSCIENCE

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

(2011) Tej K. Pareek et al.   Scientific Reports

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation

(2010) Wakako Takabe et al.   ANTIOXIDANTS & REDOX SIGNALING

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages

(2010) An Na Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

(2010) Kyoung Moo Choi et al.   GASTROENTEROLOGY

Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver

(2010) Soo Han Bae et al.   HEPATOLOGY

Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release

(2010) Elena Sierra-Filardi et al.   IMMUNOBIOLOGY

Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia

(2010) Nita Radhakrishnan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor-α, and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

(2010) Lei Mao et al.   MEDIATORS OF INFLAMMATION

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway

(2010) Jang-Shiun Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis

(2010) Joydeb Kumar Kundu et al.   PHARMACEUTICAL RESEARCH

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

(2010) Ilaria Bellezza et al.   Cancers

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice

(2009) N. M. Reddy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury

(2009) Wei Jin et al.   MEDIATORS OF INFLAMMATION

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disruption of NAD(P)H:Quinone Oxidoreductase 1 Gene in Mice Leads to Radiation-Induced Myeloproliferative Disease

(2008) K. Iskander et al.   CANCER RESEARCH

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis

(2008) Mustafa Zakkar et al.   CIRCULATION RESEARCH

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamine Reduces TNF-α by Enhancing Glutathione Synthesis in Lipopolysaccharide-Stimulated Alveolar Epithelial Cells of Rats

(2008) Feng Zhang et al.   INFLAMMATION

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One