Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages

STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

(2021) Qiang Guo et al.   Cell Death & Disease

The role of macrophages in osteoarthritis and cartilage repair

(2020) C.-L. Wu et al.   OSTEOARTHRITIS AND CARTILAGE

Macrophage: A Potential Target on Cartilage Regeneration

(2020) Tiago Lazzaretti Fernandes et al.   Frontiers in Immunology

Cell Senescence, DNA Damage, and Metabolism

(2020) Riva Shmulevich et al.   ANTIOXIDANTS & REDOX SIGNALING

4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species

(2020) Feng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

(2020) Ping-Chang Kuo et al.   Journal of Neuroinflammation

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

(2020) Mounir El Maï et al.   eLife

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

(2020) Kaitlyn A Sun et al.   eLife

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

DNA Damage and Cancer Immunotherapy: A STING in the Tale

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Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

(2020) Doo Ri Park et al.   Nature Communications

Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

(2020) Jonathan Muri et al.   Redox Biology

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging

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Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

(2019) Feng Zhou et al.   Acta Pharmaceutica Sinica B

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

(2019) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

(2019) R.R. Bannuru et al.   OSTEOARTHRITIS AND CARTILAGE

Octyl-itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling

(2019) Xuewu Sun et al.   FASEB JOURNAL

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

The Immunomodulatory Potential of the Metabolite Itaconate

(2019) Alexander Hooftman et al.   TRENDS IN IMMUNOLOGY

Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

(2019) Chengcheng Yin et al.   Acta Biomaterialia

The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling

(2019) Xuewu Sun et al.   Redox Biology

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

(2018) Yujie Deng et al.   Nature Communications

DNA damage-induced immune response: Micronuclei provide key platform

(2017) Nelson O. Gekara   JOURNAL OF CELL BIOLOGY

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

(2015) Johannes Meiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation and intracellular metabolism: new targets in OA

(2015) R. Liu-Bryan   OSTEOARTHRITIS AND CARTILAGE

Future nanomedicine for the diagnosis and treatment of osteoarthritis

(2014) Lauren R Eichaker et al.   Nanomedicine

The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli

(2014) B. Steinecker-Frohnwieser et al.   OSTEOARTHRITIS AND CARTILAGE

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Polyethylene wear particles play a role in development of osteoarthritis via detrimental effects on cartilage, meniscus, and synovium

(2013) D.Y. Park et al.   OSTEOARTHRITIS AND CARTILAGE

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

(2012) J. Rose et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium

(2012) Anak ASSK Dharmapatni et al.   ARTHRITIS RESEARCH & THERAPY

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

(2011) J.S. Lewis et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig

(2010) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE