TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Macrophages regulate the progression of osteoarthritis

(2020) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

(2020) Sharon L. Kolasinski et al.   Arthritis & Rheumatology

The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees

(2020) Brittany D. Partain et al.   JOURNAL OF CONTROLLED RELEASE

The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

(2020) Marta Piotrowska et al.   PHARMACOLOGICAL RESEARCH

Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation

(2019) Jing Xu et al.   Advanced Science

Randomized, Double‐Blind, Placebo‐Controlled Trial of Intra‐articular CNTX ‐4975 ( trans‐ capsaicin) for Pain Associated With Osteoarthritis of the Knee

(2019) Randall M. Stevens et al.   Arthritis & Rheumatology

M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling

(2019) Zhaoyun Zong et al.   Frontiers in Immunology

Ultraviolet B irradiation induced Nrf2 degradation occurs via activation of TRPV1 channels in human dermal fibroblasts

(2019) Kuo-Feng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1

(2019) Takashi Ohtsuki et al.   EXPERIMENTAL CELL RESEARCH

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization

(2019) O.R. Mahon et al.   OSTEOARTHRITIS AND CARTILAGE

Relevance of Nrf2 and heme oxygenase-1 in articular diseases

(2019) Maria José Alcaraz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis

(2018) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel

(2018) Kuo-Feng Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons

(2018) Matthew R. Sapio et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist

(2018) M. J. Iadarola et al.   PAIN

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Fluorescent Ca2+indicators directly inhibit the Na,K-ATPase and disrupt cellular functions

(2018) Nathan A. Smith et al.   Science Signaling

Fluorescent Ca2+indicators directly inhibit the Na,K-ATPase and disrupt cellular functions

(2018) Nathan A. Smith et al.   Science Signaling

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

(2018) Jiwei Hou et al.   Cell Communication and Signaling

Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets

(2018) Brent M. Wood et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo

(2017) Peng Zhong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sensory TRP channels contribute differentially to skin inflammation and persistent itch

(2017) Jing Feng et al.   Nature Communications

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

(2017) Raffaele Simeoli et al.   Nature Communications

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

TRPV1 Channel: A Potential Drug Target for Treating Epilepsy

(2015) Mustafa Nazıroglu   Current Neuropharmacology

TRPs and pain

(2015) Yi Dai   Seminars in Immunopathology

Synovitis in knee osteoarthritis: a precursor of disease?

(2014) I Atukorala et al.   ANNALS OF THE RHEUMATIC DISEASES

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

(2014) Wenjuan Xuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective

(2014) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

(2014) Samuel Bertin et al.   NATURE IMMUNOLOGY

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages

(2010) An Na Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE