Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

A Facile Synthesis of Isotope Labeled Acylcarnitines

(2021) Xiaojun Dai et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of α-Deuterated Primary Amines via Reductive Deuteration of Oximes Using D2O as a Deuterium Source

(2021) Lei Ning et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt-Catalyzed Protodeboronation of Aryl and Vinyl Boronates

(2021) Ninglin Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Excited-State Palladium-Catalyzed 1,2-Spin-Center Shift Enables Selective C-2 Reduction, Deuteration, and Iodination of Carbohydrates

(2021) Gaoyuan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization

(2021) Qi-Kai Kang et al.   SYNLETT

Visible-light-mediated deuteration of aldehydes with D2O via polarity-matched reversible hydrogen atom transfer

(2021) Jian-Yang Dong et al.   TETRAHEDRON

A practical and efficient method for late-stage deuteration of terminal alkynes with silver salt as catalyst

(2021) Ding-Chuan Wu et al.   TETRAHEDRON LETTERS

Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis

(2021) Adrian Tlahuext-Aca et al.   ACS Catalysis

Site-Selective Silver-Catalyzed C–H Bond Deuteration of Five-Membered Aromatic Heterocycles and Pharmaceuticals

(2021) Adrian Tlahuext-Aca et al.   ACS Catalysis

Nanocatalyzed Hydrogen Isotope Exchange

(2021) Marco Lepron et al.   ACCOUNTS OF CHEMICAL RESEARCH

Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

(2021) Linwei Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Multideuterated (Hetero)aryl Bromides by Ag(I)-Catalyzed H/D Exchange

(2021) Guang-Qi Hu et al.   ORGANIC LETTERS

Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water

(2021) Jack S. Rowbotham et al.   ACS Catalysis

Mechanism of the Arene‐Limited Nondirected C–H Activation of Arenes with Palladium

(2021) Philipp Wedi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes

(2021) Zoua Pa Vang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium‐catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group

(2021) Sara Kopf et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides

(2021) Bhagat Singh et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy

(2021) Zoua Pa Vang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Photodehalogenation of Aryl Bromides

(2021) Ruben Martin et al.   SYNLETT

Harnessing ynamide activation to access deuterated carbonyls

(2021) Vincent Porte et al.   TETRAHEDRON

Protecting Benzylic CH Bonds by Deuteration Doubles the Operational Lifetime of Deep‐Blue Ir‐Phenylimidazole Dopants in Phosphorescent OLEDs

(2021) Hye Jin Bae et al.   Advanced Optical Materials

Remote Site‐Selective Radical C(sp 3 )−H Monodeuteration of Amides using D 2 O

(2021) Lin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ambient Hydrogenation and Deuteration of Alkenes Using a Nanostructured Ni‐Core–Shell Catalyst

(2021) Jie Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Deuterated “Magic Methyl” Group: A Guide to Site‐Selective Trideuteromethyl Incorporation and Labeling by Using CD 3 Reagents

(2021) Joost Steverlynck et al.   CHEMISTRY-A EUROPEAN JOURNAL

Indium Tribromide‐Catalysed Transfer‐Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes

(2021) Luomo Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Late-Stage β-C(sp3)–H Deuteration of Carboxylic Acids

(2021) Alexander Uttry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CF2DSO2Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation

(2021) Junqing Liang et al.   ORGANIC LETTERS

Synthesis of α-Deuterioalcohols by Single-Electron Umpolung Reductive Deuteration of Carbonyls Using D2O as Deuterium Source

(2021) Yuxia Hou et al.   SYNLETT

Base‐Catalyzed Selective Deuteration of Alkynes

(2021) Shiv Kumar et al.   Asian Journal of Organic Chemistry

Additive‐Free Visible‐Light‐Mediated Hydro‐/Deuterodediazoniation of Arenediazonium Tetrafluoroborates in THF/THF‐ d 8

(2021) Lian Yang et al.   Asian Journal of Organic Chemistry

Palladium-Catalyzed Nondirected Late-Stage C–H Deuteration of Arenes

(2021) Mirxan Farizyan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration

(2021) Santosh C. Gadekar et al.   ACS Catalysis

C−H Functionalization-Prediction of Selectivity in Iridium(I)-Catalyzed Hydrogen Isotope Exchange Competition Reactions

(2020) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Base metal-catalyzed hydrogen isotope exchange

(2020) Haifeng Yang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C–H Arylation of Heteroarenes

(2020) Qui-Hien Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions

(2020) Noam I. Saper et al.   Nature Chemistry

Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel

(2020) Siyu Guo et al.   ORGANIC LETTERS

Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O

(2020) Nengbo Zhu et al.   ORGANIC LETTERS

Synthesis of Enantioenriched α-Deuterated α-Amino Acids Enabled by an Organophotocatalytic Radical Approach

(2020) Peng Ji et al.   ORGANIC LETTERS

Pentafluorophenyl Esters: Highly Chemoselective Ketyl Precursors for the Synthesis of α,α-Dideuterio Alcohols Using SmI2 and D2O as a Deuterium Source

(2020) Hengzhao Li et al.   ORGANIC LETTERS

Regiodivergent DH or HD Addition to Alkenes: Deuterohydrogenation versus Hydrodeuterogenation

(2020) Luomo Li et al.   ORGANIC LETTERS

Mesoionic Carbene–Iridium Complex Catalyzed Ortho-Selective Hydrogen Isotope Exchange of Anilines with High Functional Group Tolerance

(2020) Wei Liu et al.   ORGANIC LETTERS

Water Compatible Hypophosphites-d2 Reagents: Deuteration Reaction via Deutero-deiodination in Aqueous Solution

(2020) Zejin Song et al.   ORGANIC LETTERS

N-Heterocyclic Carbene Catalyzed Deuteration of Aldehydes in D2O

(2020) Yoshinari Sawama et al.   SYNLETT

Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach

(2020) Yueteng Zhang et al.   ACS Catalysis

The Natural Product Lepidiline A as an N-Heterocyclic Carbene Ligand Precursor in Complexes of the Type [Ir(cod)(NHC)PPh3)]X: Synthesis, Characterisation, and Application in Hydrogen Isotope Exchange Catalysis

(2020) Alison R. Cochrane et al.   Catalysts

Iridium(I) Complexes with Anionic N‐Heterocyclic Carbene Ligands as Catalysts for H/D Exchange in Nonpolar Media

(2020) Marvin Koneczny et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemical‐Reductant‐Free Electrochemical Deuteration Reaction using Deuterium Oxide

(2020) Xu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium Exchange between Arenes and Deuterated Solvents in the Absence of a Transition Metal: Synthesis of D-Labeled Fluoroarenes

(2020) Vanesa Salamanca et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

S-(4-Nitrobenzyl)-6-thioinosine: tritium labelling at high specific activity

(2020) Crist N. Filer et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors

(2020) Jonas Bergare et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Exhaustive Reduction of Esters Enabled by Nickel Catalysis

(2020) Adam Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late-stage oxidative C(sp3)–H methylation

(2020) Kaibo Feng et al.   NATURE

Preparation of cyclohexene isotopologues and stereoisotopomers from benzene

(2020) Jacob A. Smith et al.   NATURE

Connecting remote C–H bond functionalization and decarboxylative coupling using simple amines

(2020) Francisco de Azambuja et al.   Nature Chemistry

N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates

(2020) Marc Magre et al.   ORGANIC LETTERS

Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis

(2020) Giovanni Maestri et al.   SYNTHESIS-STUTTGART

Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

(2020) J. S. Rowbotham et al.   Nature Communications

Diverse meta-C–H Functionalization of Amides

(2020) Aniket Gholap et al.   ACS Catalysis

Carbene-Catalyzed α,γ-Deuteration of Enals under Oxidative Conditions

(2020) Xiaolei Zhang et al.   ACS Catalysis

Bioinspired design of a robust d3-methylating agent

(2020) Minyan Wang et al.   Science Advances

Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration

(2020) Yong Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Electrocatalytic Deuteration of Halides with D2O as the Deuterium Source over a Copper Nanowire Arrays Cathode

(2020) Cuibo Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regiodivergent C–H and C–C Alkylation by Ruthenium Catalysis: ortho versus meta Position‐Selectivity

(2020) Korkit Korvorapun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiple Site Hydrogen Isotope Labelling of Pharmaceuticals

(2020) Marion Daniel-Bertrand et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tuning the Reactivity of a Heterogeneous Catalyst using N‐Heterocyclic Carbene Ligands for C‐H Activation Reactions

(2020) Alberto Palazzolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow

(2020) Wai Chung Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Transfer Semihydrogenation of Alkynes with H2O (D2O) as the H (D) Source over a Pd‐P Cathode

(2020) Yongmeng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodobenzene-catalyzed oxidative C H d-alkoxylation of quinoxalinones with deuterated alcohols

(2020) Jianzhong Jin et al.   CATALYSIS COMMUNICATIONS

Photoredox‐mediated Hydrogen Isotope Exchange Reactions of Amino‐Acids, Peptides and Peptide‐derived drugs

(2020) Fabien Legros et al.   CHEMISTRY-A EUROPEAN JOURNAL

Primary Vinyl Ethers as Acetylene Surrogate: A Flexible Tool for Deuterium-Labeled Pyrazole Synthesis

(2020) Maria S. Ledovskaya et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of tri-deuterated (-)-geosmin to be used as internal standard in quantitation assays

(2020) Caterina Porcelli et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

(2020) Ahmed Haider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Hydrogenolysis of Aryl C–F Bonds Using a Bimetallic Rhodium–Indium Complex

(2020) James T. Moore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Streamlined Construction of Silicon-Stereogenic Silanes by Tandem Enantioselective C–H Silylation/Alkene Hydrosilylation

(2020) Delong Mu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancement of a Heroin Vaccine through Hapten Deuteration

(2020) Tyson F. Belz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A straightforward catalytic approach to obtain deuterated chloroform at room temperature

(2020) Angel Ruben Higuera-Padilla et al.   MAGNETIC RESONANCE IN CHEMISTRY

Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange

(2020) Jinquan Zhang et al.   ACS Catalysis

Hydrogen Isotope Exchange with Superbulky Alkaline Earth Metal Amide Catalysts

(2020) Johannes Martin et al.   ACS Catalysis

Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters

(2020) Stephanie W. Chun et al.   ACS Catalysis

C(sp2)–H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene-d6 as a Deuterium Source

(2020) Javier Corpas et al.   ACS Catalysis

Iron(III)-Mediated Rapid Radical-Type Three-Component Deuteration of Quinoxalinones With Olefins and NaBD4

(2020) Wanmei Li et al.   Frontiers in Chemistry

Electrolytic deuteration of unsaturated bonds without using D2

(2020) Aiko Kurimoto et al.   Nature Catalysis

Iridium‐Catalysed Reductive Deoxygenation of Ketones with Formic Acid as Traceless Hydride Donor

(2020) Zhiheng Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct β‐ and γ‐C(sp 3 )−H Alkynylation of Free Carboxylic Acids

(2020) Francesca Ghiringhelli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogen Bond Donor Solvents Enabled Catalyst‐free (Radio)‐Halogenation and Deuteration of Organoborons

(2020) Yi Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoselective Alpha‐Deuteration of Amides Via Retro‐ene Reaction

(2020) Vincent Porte et al.   CHEMISTRY-A EUROPEAN JOURNAL

Shifted Selectivity in Protonation Enables the Mild Deuteration of Arenes Through Catalytic Amounts of Bronsted Acids in Deuterated Methanol

(2020) Oliver Fischer et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Atroposelective Oxidative C–H/C–H Cross-Coupling Reaction of 1-Aryl Isoquinoline Derivatives with Electron-Rich Heteroarenes

(2020) Qiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Regiodivergent Alkyne Hydrosilylation

(2020) Meng-Yang Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile H/D Exchange at (Hetero)Aromatic Hydrocarbons Catalyzed by a Stable Trans-Dihydride N-Heterocyclic Carbene (NHC) Iron Complex

(2020) Subhash Garhwal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Asymmetric Transfer Hydrogenation and α-Selective Deuteration of N-Sulfonyl Imines with Alcohols: Access to α-Deuterated Chiral Amines

(2020) Peng Yang et al.   ORGANIC LETTERS

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation–Deuteration of Heterobenzylic Methylenes

(2020) Yonghai Liu et al.   ORGANIC LETTERS

Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D2O as Deuterium Source

(2020) Xiaodong Ma et al.   SYNLETT

Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

(2020) Zhaofei Zhang et al.   Nature Communications

Computationally-Guided Development of a Chelated NHC-P Iridium(I) Complex for the Directed Hydrogen Isotope Exchange of Aryl Sulfones

(2020) William J. Kerr et al.   ACS Catalysis

Organocatalytic Deuteration Induced by the Dynamic Covalent Interaction of Imidazolium Cations with Ketones

(2020) Konstantin I. Galkin et al.   ADVANCED SYNTHESIS & CATALYSIS

Room‐temperature Palladium‐Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals

(2020) Wei Ou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery

(2020) Robert W. Pipal et al.   NATURE

Breaking the Symmetry of a Meso Compound by Isotopic Substitution: Synthesis and Stereochemical Assignment of Monodeuterated cis-Perhydroazulene

(2020) Fumito Saito et al.   ORGANIC LETTERS

Regioselective α-Deuteration of Michael Acceptors Mediated by Isopropylamine in D2O/AcOD

(2020) Vinod G. Landge et al.   ORGANIC LETTERS

Scalable synthesis of the aroma compounds d6-β-ionone and d6-β-cyclocitral for use as internal standards in stable isotope dilution assays

(2020) Shabnam Mosaferi et al.   TETRAHEDRON LETTERS

Facile and Economical Electrochemical Dehalogenative Deuteration of (Hetero)Aryl Halides

(2020) Lijun Lu et al.   CCS Chemistry

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic α-Selective Deuteration of Styrene Derivatives

(2019) Thomas R. Puleo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

(2019) Zuyuan Shen et al.   ORGANIC LETTERS

40 Years of Hydrogen–Deuterium Exchange Adjacent to Heteroatoms: A Survey

(2019) Maxime Roche et al.   SYNTHESIS-STUTTGART

Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

(2019) Jakapun Soponpong et al.   TETRAHEDRON LETTERS

H–D Exchange Deuteration of Arenes at Room Temperature

(2019) Yoshinari Sawama et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Palladium Catalyzed Hydrodefluorination of Fluoro-(hetero)arenes

(2019) Joseph J. Gair et al.   ORGANIC LETTERS

Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes

(2019) Chuan-Qi Zhao et al.   ORGANIC LETTERS

Ni(I)–X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals

(2019) Cayetana Zarate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir-Catalyzed Intermolecular Branch-Selective Allylic C–H Amidation of Unactivated Terminal Olefins

(2019) Honghui Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diboron-Assisted Copper-Catalyzed Z-Selective Semihydrogenation of Alkynes Using Ethanol as a Hydrogen Donor

(2019) Hanyang Bao et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat and human microsomes

(2019) Xinmin Gan et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ni-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines

(2019) Bowen Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange

(2019) Alberto Palazzolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity-oriented Desulfonylative Functionalization of Alkyl Allyl Sulfones

(2019) Yong Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium‐Catalyzed Selective meta ‐C−H Deuteration of Arenes: Reaction Design and Applications

(2019) Sukdev Bag et al.   CHEMISTRY-A EUROPEAN JOURNAL

Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides

(2019) Mégane Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2

(2019) Markus Artelsmair et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Rhodium-Catalyzed Selective C–H Trideuteromethylation of Indole at C7 Position Using Acetic-d6 Anhydride

(2019) Xiaowei Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Regioselective C–H Iodination of Unactivated Alkenes

(2019) Benedikt Schreib et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Synthesis of C6-Modified Sugar Nucleotides To Probe the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa

(2019) Sanaz Ahmadipour et al.   ORGANIC LETTERS

Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium Carbide

(2019) Maria Ledovskaya et al.   SYNTHESIS-STUTTGART

Cobalt‐Catalyzed Transfer Hydrogenation of α‐Ketoesters and N ‐Cyclicsulfonylimides Using H 2 O as Hydrogen Source

(2019) Yang Gao et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α‐Fluoroketones

(2019) Kui Liao et al.   CHINESE JOURNAL OF CHEMISTRY

Highlights of aliphatic C (sp3 )-H Hydrogen Isotope Exchange Reactions

(2019) Mégane Valero et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Tritiodefluorination of alkyl C-F groups

(2019) Břetislav Brož et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Hydro/Deutero Deamination of Arylazo Sulfones under Metal- and (Photo)Catalyst-Free Conditions

(2019) Hawraz I. M. Amin et al.   MOLECULES

Palladium-Catalyzed Remote meta-C–H Bond Deuteration of Arenes Using a Pyridine Template

(2019) Hui Xu et al.   ORGANIC LETTERS

Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides

(2019) Masami Kuriyama et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A primer of deuterium in drug design

(2019) Sarah Cargnin et al.   Future Medicinal Chemistry

Highlights of C (sp2 )-H hydrogen isotope Exchange Reactions

(2019) David Hesk   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Dehalogenative Deuteration of Unactivated Alkyl halides Using D2O as the Deuterium Source

(2019) Aiyou Xia et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C–H Bonds of Drug Molecules

(2019) Yejin Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ag2CO3-Catalyzed H/D Exchange of Five-Membered Heteroarenes at Ambient Temperature

(2019) En-Ci Li et al.   ORGANIC LETTERS

A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII

(2019) Alyssa L. Garreau et al.   ORGANIC LETTERS

Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides

(2019) Ming-Hui Zhu et al.   ORGANIC LETTERS

Continuous‐Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α‐Dideutero Amines

(2019) Rebeka Mészáros et al.   ChemPlusChem

Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

(2019) Mégane Valero et al.   ChemistryOpen

Synthesis of anti-vicinal diboronates from diarylethynes and B2pin2

(2019) Zhijie Kuang et al.   Science Bulletin

Mesoionic Carbene (MIC)-Catalyzed H/D Exchange at Formyl Groups

(2019) Wei Liu et al.   Chem

Palladium-Borane Cooperation: Evidence for an Anionic Pathway and Its Application to Catalytic Hydro-/Deutero-dechlorination

(2019) Hajime Kameo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild, Selective Ru‐Catalyzed Deuteration Using D 2 O as a Deuterium Source

(2019) Pascal Eisele et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Iridium(I) Catalysis towards Directed Hydrogen Isotope Exchange

(2019) William J. Kerr et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Reductive Deuteration of Nitriles Using D2O as a Deuterium Source

(2019) Yuxuan Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Benzylic Alcohols by C–H Oxidation

(2019) Lalita Tanwar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Tunable Csp3–H Bonds Functionalization by Visible-Light-Induced Radical Translocation of N-Alkoxyphthalimides

(2019) Chuanyong Wang et al.   ORGANIC LETTERS

Scalable Synthesis of Acridinium Catalysts for Photoredox Deuterations

(2019) Bouthayna Zilate et al.   SYNTHESIS-STUTTGART

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis

(2019) Huihui Geng et al.   Nature Catalysis

B(C 6 F 5 ) 3 ‐Catalyzed α ‐Deuteration of Bioactive Carbonyl Compounds with D 2 O

(2019) Yejin Chang et al.   ADVANCED SYNTHESIS & CATALYSIS

NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines

(2019) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation

(2019) Valentin Müller et al.   ChemCatChem

Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N‐Heterocycles and Reaction Mechanism Insights

(2019) Grégory Pieters et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium-Catalyzed ortho- and meta-H/D Exchange of Arenes

(2019) Liang-Liang Zhao et al.   ORGANIC LETTERS

New Dopamine D2 Receptor Agonist, [3H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo

(2018) Sivan Subburaju et al.   ACS Chemical Neuroscience

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water-Gas Shift Reaction

(2018) Malek Y. S. Ibrahim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective α-Monomethylation by an Amine-Borane/N,N-Dimethylformamide System as the Methyl Source

(2018) Hui-Min Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)–H bonds directed by a sulfur atom

(2018) Longhui Gao et al.   CHEMICAL COMMUNICATIONS

Ruthenium-catalyzed selective α-deuteration of aliphatic nitriles using D2O

(2018) Varadhan Krishnakumar et al.   CHEMICAL COMMUNICATIONS

Metal-free Halogen(I) Catalysts for Oxidation of (Aryl)(heteroaryl)-methanes to Ketones or Esters : Selectivity Control by Halogen Bond

(2018) SOMRAJ GUHA et al.   CHEMISTRY-A EUROPEAN JOURNAL

DMSO as a Switchable Alkylating Agent in Heteroarene C−H Functionalization

(2018) R. Aleyda Garza-Sanchez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reductive Cleavage Method for Quantitation of Monolignols and Low-Abundance Monolignol Conjugates

(2018) Matt Regner et al.   ChemSusChem

Enantioselective Deuteration of β-Substituted α,β-Unsaturated Esters by Rhodium-1,2-Bis(2,5-diphenylphospholano)ethane

(2018) Sébastien Lethu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Regioselective deuteration of alcohols in D2O catalysed by homogeneous manganese and iron pincer complexes

(2018) Sayan Kar et al.   GREEN CHEMISTRY

Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

(2018) Mégane Valero et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of stable isotope-labeled nasturlexins and potential precursors to probe biosynthetic pathways of cruciferous phytoalexins

(2018) M. Soledade C. Pedras et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of 3 H, 13 C2 , 2 H4 14 C-SCH 430765 and 35 S-SCH 500946, potent and selective inhibitors of the NPY5 receptor

(2018) D. Hesk et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Reduction and Reductive Deuteration of Tertiary Amides Mediated by Sodium Dispersions with Distinct Proton Donor-Dependent Chemoselectivity

(2018) Bin Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Regioselective C–H Functionalization of Arenes Substituted by Two N-Heterocycles and Application in Late-Stage Functionalization

(2018) Da-Wei Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Method for Small-Scale Production of Deuterochloroform

(2018) Natha D. Tansukawat et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids

(2018) Donghong Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

[3 + 2]-Cycloaddition of in Situ Generated Nitrile Imines and Acetylene for Assembling of 1,3-Disubstituted Pyrazoles with Quantitative Deuterium Labeling

(2018) Vladimir V. Voronin et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbon Dioxide-Mediated C(sp3)–H Arylation of Amine Substrates

(2018) Mohit Kapoor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

(2018) J. Luke Koniarczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

(2018) Yang Geng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Transition-Metal-Free, Selective Reductive Deuteration of Terminal Alkynes with Sodium Dispersions and EtOD-d1

(2018) Minhui Han et al.   ORGANIC LETTERS

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

(2018) Xiangmin Li et al.   ORGANIC LETTERS

Palladium-catalyzed site-selective hydrogen isotope exchange (HIE) reaction of arylsulfonamides using amino acid auxiliary

(2018) Wei Liu et al.   TETRAHEDRON

Controllable deuteration of halogenated compounds by photocatalytic D2O splitting

(2018) Cuibo Liu et al.   Nature Communications

Hydrogen/Deuterium (H/D) Exchange Catalysis in Alkanes

(2018) Aaron Sattler   ACS Catalysis

Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation

(2018) Maria S. Ledovskaya et al.   Organic Chemistry Frontiers

Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation

(2018) Shan Tang et al.   Chem

Iron-Mediated Azidomethylation or Azidotrideuteromethylation of Active Alkenes with Azidotrimethylsilane and Dimethyl Sulfoxide

(2018) Rui Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in Deuterium Oxide

(2018) Kwihwan Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Arylation of Remote C(sp3 )−H Bonds in Carboxamides and Sulfonamides

(2018) Zhaodong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions

(2018) Yuxuan Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol2

(2018) Rita Sigüeiro et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

General and Practical Potassium Methoxide/Disilane-Mediated Dehalogenative Deuteration of (Hetero)Arylhalides

(2018) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Electrochemical C–H Amination of Arenes with Secondary Amines

(2018) Qi-Liang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals

(2018) Haifeng Yang et al.   ACS Catalysis

Catalytic C1  Alkylation with Methanol and Isotope-Labeled Methanol

(2018) Jan Sklyaruk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxygenative Deuteration of Carboxylic Acids with D2 O

(2018) Muliang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Biphasic Medium Slows Down the Transfer Hydrogenation and Allows a Selective Catalytic Deuterium Labeling of Amines from Imines Mediated by a Ru−H/D + Exchange in D 2 O

(2018) Margarita Ruiz‐Castañeda et al.   ChemCatChem

Ruthenium(II)biscarboxylate-Catalyzed Hydrogen-Isotope Exchange by Alkene C−H Activation

(2018) Alexander Bechtoldt et al.   ChemCatChem

Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen

(2018) Felix Pape et al.   CHEMISTRY-A EUROPEAN JOURNAL

Room Temperature Iron-Catalyzed Transfer Hydrogenation and Regioselective Deuteration of Carbon–Carbon Double Bonds

(2018) Maialen Espinal-Viguri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective Transfer Hydrodeuteration of Alkenes with a Hydrogen Deuteride Surrogate Using B(C6F5)3 Catalysis

(2018) Johannes C. L. Walker et al.   ORGANIC LETTERS

Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange

(2018) William J. Kerr et al.   ACS Catalysis

Convenient Method for the Production of Deuterium Gas Catalyzed by an Iridium Complex and Its Application to the Deuteration of Organic Compounds

(2018) Akane Enomoto et al.   CHEMISTRY LETTERS

Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts

(2017) Annina Burhop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Deuterated drugs; updates and obviousness analysis

(2017) Graham S. Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Quantitation of Rotundone in Grapefruit (Citrus paradisi) Peel and Juice by Stable Isotope Dilution Assay

(2017) Akira Nakanishi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of3H,2H4, and14C-MK 3814 (preladenant)

(2017) D. Hesk et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor

(2017) Yinsheng Zhang   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Convergent synthesis of a deuterium-labeled serine dipeptide lipid for analysis of biological samples

(2017) Christopher Dietz et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Burgess iridium(I)-catalyst for selective hydrogen isotope exchange

(2017) Annina Burhop et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Organocatalytic Imidazolium Ionic Liquids H/D Exchange Catalysts

(2017) Marcileia Zanatta et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of a Modified Bouveault–Blanc Reduction for the Selective Synthesis of α,α-Dideuterio Alcohols

(2017) Minhui Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Site-Specific Deuteration of Polyunsaturated Alkenes

(2017) A. V. Smarun et al.   JOURNAL OF ORGANIC CHEMISTRY

Radical Deuteration with D2O: Catalysis and Mechanistic Insights

(2017) Valentin Soulard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Asymmetric synthesis of α-deuterated α-amino acids

(2017) Ryosuke Takeda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes

(2017) Min Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

B(C6F5)3-Catalyzed Regioselective Deuteration of Electron-Rich Aromatic and Heteroaromatic Compounds

(2017) Wu Li et al.   ORGANIC LETTERS

Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C–H Nitration of Arenes with Removable Auxiliaries

(2017) Zhoulong Fan et al.   ORGANIC LETTERS

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Catalytic Deuteration of Aldehydes with D2O

(2017) Stephen Newman et al.   SYNLETT

A selective and cost-effective method for the reductive deuteration of activated alkenes

(2017) Hengzhao Li et al.   TETRAHEDRON LETTERS

Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps

(2017) Munia F. Sowaileh et al.   TETRAHEDRON LETTERS

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Site-Selective Deuteration of N-Heterocycles via Iridium-Catalyzed Hydrogen Isotope Exchange

(2017) William J. Kerr et al.   ACS Catalysis

Free-radical initiated cascade methylation or trideuteromethylation of isocyanides with dimethyl sulfoxides

(2017) Rui Zhang et al.   RSC Advances

Efficient Brønsted-Acid-Catalyzed Deuteration of Arenes and Their Transformation to Functionalized Deuterated Products

(2017) Xuewei Liang et al.   Asian Journal of Organic Chemistry

Nickel-Catalyzed Deoxygenative Deuteration of Aryl Sulfamates

(2016) Masami Kuriyama et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

(2016) Roberta Caporaso et al.   CHEMICAL COMMUNICATIONS

The ruthenium-catalysed selective synthesis of mono-deuterated terminal alkynes

(2016) Basujit Chatterjee et al.   CHEMICAL COMMUNICATIONS

AVP-786 for the treatment of agitation in dementia of the Alzheimer’s type

(2016) Ricardo P. Garay et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study

(2016) William J. Kerr et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors

(2016) Paul Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP)

(2016) Åsa Lindelöf et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ag(I)-Catalyzed C–H Activation: The Role of the Ag(I) Salt in Pd/Ag-Mediated C–H Arylation of Electron-Deficient Arenes

(2016) Daniel Whitaker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Meta-Selective CAr–H Nitration of Arenes through a Ru3(CO)12-Catalyzed Ortho-Metalation Strategy

(2016) Zhoulong Fan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Selective H/D Exchange at Vinyl and Methylidene Groups with D2O Catalyzed by an Iridium Complex

(2016) Miyuki Hatano et al.   ORGANIC LETTERS

Selective α-Deuteration of Amines and Amino Acids Using D2O

(2016) Basujit Chatterjee et al.   ORGANIC LETTERS

Role of Silver Salts in Palladium-Catalyzed Arene and Heteroarene C–H Functionalization Reactions

(2016) Monica D. Lotz et al.   ORGANOMETALLICS

Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds

(2015) Soumitra Agasti et al.   ADVANCED SYNTHESIS & CATALYSIS

Directedmeta-Selective Bromination of Arenes with Ruthenium Catalysts

(2015) Qingzhen Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols

(2015) Miao Zhan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient tritiation of the translocator protein (18 kDa) selective ligand DPA-714

(2015) Annelaure Damont et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Iridium-Catalysed ortho-Directed Deuterium Labelling of Aromatic Esters—An Experimental and Theoretical Study on Directing Group Chemoselectivity

(2015) Jennifer Devlin et al.   MOLECULES

Ruthenium Catalyzed Selective α- and α,β-Deuteration of Alcohols Using D2O

(2015) Basujit Chatterjee et al.   ORGANIC LETTERS

Isotopic Labelling of Functionalised Arenes Catalysed by Iridium(I) Species of the [(cod)Ir(NHC)(py)]PF6 Complex Class

(2015) William Kerr et al.   SYNLETT

Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

(2015) Jens Atzrodt et al.   TETRAHEDRON

Hydrogen–deuterium exchange of aromatic amines and amides using deuterated trifluoroacetic acid

(2015) Richard Giles et al.   TETRAHEDRON LETTERS

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed H/D Exchange: Ligand Complexes with Improved Efficiency and Scope

(2014) Michael Parmentier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium(I)-Catalyzed Regioselective CH Activation and Hydrogen-Isotope Exchange of Non-aromatic Unsaturated Functionality

(2014) William J. Kerr et al.   CHEMISTRY-A EUROPEAN JOURNAL

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective ruthenium catalysed H–D exchange using D2O as the deuterium source

(2014) Lorenzo Piola et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

(2014) A. R. Cochrane et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties

(2014) Yanmei Zhang et al.   ACS Medicinal Chemistry Letters

Selective Catalytic Deuterium Labeling of Alcohols during a Transfer Hydrogenation Process of Ketones Using D2O as the Only Deuterium Source. Theoretical and Experimental Demonstration of a Ru–H/D+ Exchange as the Key Step

(2014) M. Carmen Carrión et al.   ACS Catalysis

Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

(2014) William J. Kerr et al.   ACS Catalysis

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

(2013) Grégory Pieters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588

(2013) Paul W. Manley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Application of neutral iridium(I)N-heterocyclic carbene complexes inortho-directed hydrogen isotope exchange

(2013) Alison R. Cochrane et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells

(2013) Matthew C. O’Reilly et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents

(2013) Yaoqiu Zhu et al.   ACS Medicinal Chemistry Letters

Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols

(2013) Eugene Khaskin et al.   ACS Catalysis

Synthesis of all-deuterated tris(2-phenylpyridine)iridium for highly stable electrophosphorescence: the “deuterium effect”

(2013) Ping Wang et al.   Journal of Materials Chemistry C

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

(2012) Yong-Kang Zhang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Tritium: a coming of age for drug discovery and development ADME studies

(2012) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of Deuterated 1,2,3-Triazoles

(2012) Hari K. Akula et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mild Reaction Conditions for the Terminal Deuteration of Alkynes

(2012) Sean P. Bew et al.   ORGANIC LETTERS

Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System

(2012) Hironao Sajiki et al.   SYNLETT

Mild and Selective H/D Exchange at the β Position of Aromatic α-Olefins by N-Heterocyclic Carbene-Hydride-Rhodium Catalysts

(2011) Andrea Di Giuseppe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Regioselective Deuteration of Alcohols at the β-Carbon Position with Deuterium Oxide

(2011) Sunny Kai San Tse et al.   CHEMISTRY-A EUROPEAN JOURNAL

(η6-Arene)ruthenium(N-heterocyclic carbene) Complexes for the Chelation-Assisted Arylation and Deuteration of Arylpyridines: Catalytic Studies and Mechanistic Insights

(2010) Amparo Prades et al.   ADVANCED SYNTHESIS & CATALYSIS

Hydrogen/Deuterium Exchange Reactions of Olefins with Deuterium Oxide Mediated by the Carbonylchlorohydrido- tris(triphenylphosphine)ruthenium(II) Complex

(2010) Sunny Kai San Tse et al.   ADVANCED SYNTHESIS & CATALYSIS

Deuteration isotope effect on nonradiative transition of fac-tris (2-phenylpyridinato) iridium (III) complexes

(2010) Taichi Abe et al.   CHEMICAL PHYSICS LETTERS

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed hydrogen isotope exchange labelling: a brief overview

(2010) William J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Nickel-catalyzed hydrogen isotope exchange

(2010) J. Richard Heys   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Tritium labelling of pharmaceuticals by metal-catalysed exchange methods

(2010) D. Hesk et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Hydrogen isotope labelling using iridium(I) dionates

(2010) W. J. S. Lockley   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ni-Catalyzed Reduction of Inert C−O Bonds: A New Strategy for Using Aryl Ethers as Easily Removable Directing Groups

(2010) Paula Álvarez-Bercedo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor

(2009) Yossi Zafrani et al.   TETRAHEDRON

A Convenient and Effective Method for the Regioselective Deuteration of Alcohols

(2008) Tomohiro Maegawa et al.   ADVANCED SYNTHESIS & CATALYSIS

Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal

(2008) Tomohiro Maegawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient and Selective Pt/C-Catalyzed H–D Exchange Reaction of Aromatic Rings

(2008) Nobuhiro Ito et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

(2008) Jack A. Brown et al.   CHEMICAL COMMUNICATIONS

Facile and Convenient Method of Deuterium Gas Generation Using a Pd/C-Catalyzed H2–D2 Exchange Reaction and Its Application to Synthesis of Deuterium-Labeled Compounds

(2008) Takanori Kurita et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantification of malonylcarnitine in dried blood spots by use of MS/MS varies by stable isotope internal standard composition

(2008) Donald H. Chace et al.   CLINICA CHIMICA ACTA

Synthesis of 19-trideuteratedent-testosterone and the GABAAreceptor potentiatorsent-androsterone andent-etiocholanolone

(2008) Shirisha Komarapuri et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A Simple, Cost-Effective Method for the Regioselective Deuteration of Anilines

(2008) Andrew Martins et al.   ORGANIC LETTERS

H-D Exchange Reaction Taking Advantage of the Synergistic Effect of Heterogeneous Palladium and Platinum Mixed Catalyst

(2008) Hironao Sajiki et al.   SYNTHESIS-STUTTGART

Efficient and Convenient Heterogeneous Palladium-Catalyzed Regioselective Deuteration at the Benzylic Position

(2007) Takanori Kurita et al.   CHEMISTRY-A EUROPEAN JOURNAL