Efficient Brønsted-Acid-Catalyzed Deuteration of Arenes and Their Transformation to Functionalized Deuterated Products

A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites

(2016) Irene Thamm et al.   CHEMICAL COMMUNICATIONS

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

Mono and dimetallic pyrene-imidazolylidene complexes of iridium(iii) for the deuteration of organic substrates and the C–C coupling of alcohols

(2016) S. Ibañez et al.   DALTON TRANSACTIONS

Deuterium medicinal chemistry comes of age

(2016) Roger D Tung   Future Medicinal Chemistry

The syntheses of [14C]BMS-823778 for use in a human ADME clinical study and of [13CD313CD2]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite

(2016) Brad D. Maxwell et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Issue information

(2016)   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of a doxycycline-[13CD3] standard

(2016) James E. Bupp et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

One-Pot Synthesis of Arylketones from Aromatic Acids via Palladium-Catalyzed Suzuki Coupling

(2016) Hongxiang Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective H/D Exchange at Vinyl and Methylidene Groups with D2O Catalyzed by an Iridium Complex

(2016) Miyuki Hatano et al.   ORGANIC LETTERS

Double deuterated acetylacetone in neon matrices: infrared spectroscopy, photoreactivity and the tunneling process

(2016) Alejandro Gutiérrez-Quintanilla et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Gas phase vibrational spectroscopy of the protonated water pentamer: the role of isomers and nuclear quantum effects

(2016) Matias R. Fagiani et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Base-catalyzed hydrogen–deuterium exchange and dehalogenation reactions of 1,2,3-triazole derivatives

(2016) Dong Wang et al.   TETRAHEDRON

Substrate Activation Strategies in Rhodium(III)-Catalyzed Selective Functionalization of Arenes

(2015) Guoyong Song et al.   ACCOUNTS OF CHEMICAL RESEARCH

Molecular Interdiffusion between Stacked Layers by Solution and Thermal Annealing Processes in Organic Light Emitting Devices

(2015) Satoru Ohisa et al.   ACS Applied Materials & Interfaces

Facile synthesis of deuterium-labeled denatonium cation and its application in the quantitative analysis of Bitrex by liquid chromatography-mass spectrometry

(2015) Remigiusz Bąchor et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Nickel-Catalyzed Proton–Deuterium Exchange (HDX) Procedures for Glycosidic Linkage Analysis of Complex Carbohydrates

(2015) Neil P. J. Price et al.   ANALYTICAL CHEMISTRY

Selective catalytic deuteration of phosphorus ligands using ruthenium nanoparticles: a new approach to gain information on ligand coordination

(2015) Emma Bresó-Femenia et al.   CHEMICAL COMMUNICATIONS

A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols

(2015) Miao Zhan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient synthesis of deuterium labeled hydroxyzine and aripiprazole

(2015) Mohit Vohra et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

An improved synthesis of [26-2H3]castasterone

(2015) Vladimir N. Zhabinskii et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A convenient method for palladium-catalyzed reductive deuteration of organic substrates using deuterated hypophosphite in D2O

(2015) Makoto Oba   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Monoamine oxidase: radiotracer chemistry and human studies

(2015) Joanna S. Fowler et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Harnessing C–H Borylation/Deborylation for Selective Deuteration, Synthesis of Boronate Esters, and Late Stage Functionalization

(2015) Venkata A Kallepalli et al.   JOURNAL OF ORGANIC CHEMISTRY

Deuteration of Perylene Enhances Photochemical Upconversion Efficiency

(2015) Andrew Danos et al.   Journal of Physical Chemistry Letters

In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel–Crafts benzylation

(2015) Justine Desroches et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ruthenium Catalyzed Selective α- and α,β-Deuteration of Alcohols Using D2O

(2015) Basujit Chatterjee et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Deuteration of Alcohols with Deuterium Oxide

(2015) Wei Bai et al.   ORGANOMETALLICS

A convenient synthesis of deuterium labeled amines and nitrogen heterocycles with KOt-Bu/DMSO-d6

(2015) Yu Hu et al.   TETRAHEDRON

H–D exchange in deuterated trifluoroacetic acid via ligand-directed NHC–palladium catalysis: a powerful method for deuteration of aromatic ketones, amides, and amino acids

(2015) Richard Giles et al.   TETRAHEDRON LETTERS

Mild deuteration method of terminal alkynes in heavy water using reusable basic resin

(2015) Tsuyoshi Yamada et al.   RSC Advances

Multiple deuteration of alkanes synergistically-catalyzed by platinum and rhodium on carbon as a mixed catalytic system

(2015) Tsuyoshi Yamada et al.   RSC Advances

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy

(2014) Fengzhi Zhang et al.   CHEMICAL SOCIETY REVIEWS

Hydride-Rhodium(III)-N-Heterocyclic Carbene Catalysts for Vinyl-Selective H/D Exchange: A Structure-Activity Study

(2014) Andrea Di Giuseppe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis of uniformly deuteratedn-dodecyl-β-d-maltoside (d39-DDM) for solubilization of membrane proteins in TROSY NMR experiments

(2014) Kazumi Hiruma-Shimizu et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

(2014) Ge Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 CH oxidation

(2014) Chao He et al.   TETRAHEDRON LETTERS

Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations

(2013) Lutz Ackermann   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

(2013) Grégory Pieters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuteration of boranes: catalysed versus non-catalysed processes

(2013) David J. Nelson et al.   DALTON TRANSACTIONS

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors

(2013) Stefania Terracciano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rapid and Controllable Hydrogen/Deuterium Exchange on Aromatic Rings of α-Amino Acids and Peptides

(2013) Yuta Murai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereotopic and Deuterium Effects in Gemini

(2013) Hubert Maehr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Joint X-ray/Neutron Crystallographic Study of HIV-1 Protease with Clinical Inhibitor Amprenavir: Insights for Drug Design

(2013) Irene T. Weber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cu-Catalyzed Mild C(sp2)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes

(2013) Joan Gallardo-Donaire et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Suzuki–Miyaura Couplings in Green Solvents

(2013) Stephen D. Ramgren et al.   ORGANIC LETTERS

Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation

(2013) Carlos Arroniz et al.   ORGANIC LETTERS

Mesoionic Carbene–Boranes

(2013) Luiza Baptista de Oliveira Freitas et al.   ORGANOMETALLICS

Development of Deuterium Labeling Method Based on the Heterogeneous Platinum Group Metal-Catalyzed C-H Activation

(2013) Hironao Sajiki   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols

(2013) Eugene Khaskin et al.   ACS Catalysis

Recent development of direct asymmetric functionalization of inert C–H bonds

(2013) Chao Zheng et al.   RSC Advances

Arenium Acid Catalyzed Deuteration of Aromatic Hydrocarbons

(2012) Simon Duttwyler et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid, Microwave-Assisted Perdeuteration of Polycyclic Aromatic Hydrocarbons

(2012) Allison K. Greene et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mild Reaction Conditions for the Terminal Deuteration of Alkynes

(2012) Sean P. Bew et al.   ORGANIC LETTERS

Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System

(2012) Hironao Sajiki et al.   SYNLETT

Carboxylic Acids as Traceless Directing Groups for Formal meta-Selective Direct Arylation

(2011) Josep Cornella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microwave-Assisted Direct H/D Exchange Reactions of Dimetridazole and Metronidazole in Alkaline D2O

(2011) Akira Miyazawa et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Catalytic deuteration of silanes mediated by N-heterocyclic carbene-Ir(iii) complexes

(2011) George C. Fortman et al.   CHEMICAL COMMUNICATIONS

Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms

(2011) Mar Gómez-Gallego et al.   CHEMICAL REVIEWS

Catalytic CH Bond Activation at Nanoscale Lewis Acidic Aluminium Fluorides: H/D Exchange Reactions at Aromatic and Aliphatic Hydrocarbons

(2011) Martin H. G. Prechtl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient Synthesis of Phenols by Copper-Catalyzed Hydroxylation of Aryl Iodides, Bromides, and Chlorides

(2011) Kai Yang et al.   ORGANIC LETTERS

Deuteration of molecules for neutron reflectometry on organic light-emitting diode thin films

(2011) Tamim A. Darwish et al.   TETRAHEDRON LETTERS

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Halogen–deuterium exchange reaction mediated by tributyltin hydride using THF-d8 as the deuterium source

(2010) Tomonobu Mutsumi et al.   TETRAHEDRON

Cross Dehydrogenative Arylation (CDA) of a Benzylic CH Bond with Arenes by Iron Catalysis

(2009) Yi-Zhou Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogen-Deuterium Exchange Reactions of Aromatic Compounds and Heterocycles by NaBD4-Activated Rhodium, Platinum and Palladium Catalysts

(2009) Volker Derdau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Bis(N-arylamino)phosphine-oxazolines: Synthesis and Application in Asymmetric Catalysis

(2008) Marc Schönleber et al.   ADVANCED SYNTHESIS & CATALYSIS

Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal

(2008) Tomohiro Maegawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium‐Catalyzed H/D Exchange at Vinyl Groups without Olefin Isomerization

(2008) Jianrong Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective sp2and Benzylic sp3Palladium-Catalyzed Direct Arylation

(2008) Louis-Charles Campeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Simple, Cost-Effective Method for the Regioselective Deuteration of Anilines

(2008) Andrew Martins et al.   ORGANIC LETTERS

Chelation-assisted rhodium hydride-catalyzed regioselective H/D exchange in arenes

(2008) Shanshan Chen et al.   TETRAHEDRON LETTERS