Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts

(2017) Annina Burhop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Burgess iridium(I)-catalyst for selective hydrogen isotope exchange

(2017) Annina Burhop et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Mechanistic considerations on catalytic H/D exchange mediated by organometallic transition metal complexes

(2015) Andrea Di Giuseppe et al.   COMPTES RENDUS CHIMIE

Photoaffinity labeling in target- and binding-site identification

(2015) Ewan Smith et al.   Future Medicinal Chemistry

Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

(2015) Jens Atzrodt et al.   TETRAHEDRON

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed H/D Exchange: Ligand Complexes with Improved Efficiency and Scope

(2014) Michael Parmentier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

(2014) A. R. Cochrane et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

(2014) Brigitte Buscher et al.   Bioanalysis

Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

(2014) William J. Kerr et al.   ACS Catalysis

Transition metal complexes supported by highly basic imidazolin-2-iminato and imidazolin-2-imine N-donor ligands

(2013) Xian Wu et al.   COORDINATION CHEMISTRY REVIEWS

Fluorophores and Their Applications as Molecular Probes in Living Cells

(2013) Junjia Liu et al.   CURRENT ORGANIC CHEMISTRY

Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form

(2013) Roger Simonsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Application of neutral iridium(I)N-heterocyclic carbene complexes inortho-directed hydrogen isotope exchange

(2013) Alison R. Cochrane et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A Comparison between Oxazoline-imidazolinylidene, -imidazolylidine, -benzimidazolylidene Hydrogenation Catalysts

(2013) Sakunchai Khumsubdee et al.   JOURNAL OF ORGANIC CHEMISTRY

5-Azido-2-aminopyridine, a New Nitrene/Nitrenium Ion Photoaffinity Labeling Agent That Exhibits Reversible Intersystem Crossing between Singlet and Triplet Nitrenes

(2013) Maxim S. Panov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoaffinity Labeling of Plasma Proteins

(2013) Victor Chuang et al.   MOLECULES

Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution

(2012) Eric G. Solon   CHEMICAL RESEARCH IN TOXICOLOGY

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

(2012) Daniel Harder et al.   Nature Protocols

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monitoring free drug concentrations: challenges

(2011) Florin Marcel Musteata   Bioanalysis

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen isotope labelling using iridium(I) dionates

(2010) W. J. S. Lockley   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Carbene-Metal Hydrides Can Be Much Less Acidic Than Phosphine-Metal Hydrides: Significance in Hydrogenations

(2010) Ye Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen-Deuterium Exchange Reactions of Aromatic Compounds and Heterocycles by NaBD4-Activated Rhodium, Platinum and Palladium Catalysts

(2009) Volker Derdau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

(2009) T. Usui et al.   DRUG METABOLISM AND DISPOSITION

Tritium labelled photoaffinity agents

(2009) Crist N. Filer   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

(2008) Jack A. Brown et al.   CHEMICAL COMMUNICATIONS

Chelation-assisted rhodium hydride-catalyzed regioselective H/D exchange in arenes

(2008) Shanshan Chen et al.   TETRAHEDRON LETTERS