Synthesis of Multideuterated (Hetero)aryl Bromides by Ag(I)-Catalyzed H/D Exchange

C−H Functionalization-Prediction of Selectivity in Iridium(I)-Catalyzed Hydrogen Isotope Exchange Competition Reactions

(2020) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mesoionic Carbene–Iridium Complex Catalyzed Ortho-Selective Hydrogen Isotope Exchange of Anilines with High Functional Group Tolerance

(2020) Wei Liu et al.   ORGANIC LETTERS

Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange

(2020) Jinquan Zhang et al.   ACS Catalysis

C(sp2)–H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene-d6 as a Deuterium Source

(2020) Javier Corpas et al.   ACS Catalysis

H–D Exchange Deuteration of Arenes at Room Temperature

(2019) Yoshinari Sawama et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Ni(I)–X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals

(2019) Cayetana Zarate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange

(2019) Alberto Palazzolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium‐Catalyzed Selective meta ‐C−H Deuteration of Arenes: Reaction Design and Applications

(2019) Sukdev Bag et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enabling Two-Electron Pathways with Iron and Cobalt: From Ligand Design to Catalytic Applications

(2019) Rebeca Arevalo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Photosensitized Aryl and Alkyl Decarboxylative Functionalization Reactions

(2019) Tuhin Patra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydro/Deutero Deamination of Arylazo Sulfones under Metal- and (Photo)Catalyst-Free Conditions

(2019) Hawraz I. M. Amin et al.   MOLECULES

Palladium-Catalyzed Remote meta-C–H Bond Deuteration of Arenes Using a Pyridine Template

(2019) Hui Xu et al.   ORGANIC LETTERS

Ag2CO3-Catalyzed H/D Exchange of Five-Membered Heteroarenes at Ambient Temperature

(2019) En-Ci Li et al.   ORGANIC LETTERS

Ruthenium-Catalyzed ortho- and meta-H/D Exchange of Arenes

(2019) Liang-Liang Zhao et al.   ORGANIC LETTERS

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd Metal Catalysts for Cross-Couplings and Related Reactions in the 21st Century: A Critical Review

(2018) Andrea Biffis et al.   CHEMICAL REVIEWS

Geometric isotope effect of deuteration in a hydrogen-bonded host–guest crystal

(2018) Chao Shi et al.   Nature Communications

Controllable deuteration of halogenated compounds by photocatalytic D2O splitting

(2018) Cuibo Liu et al.   Nature Communications

Hydrogen/Deuterium (H/D) Exchange Catalysis in Alkanes

(2018) Aaron Sattler   ACS Catalysis

Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in Deuterium Oxide

(2018) Kwihwan Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals

(2018) Haifeng Yang et al.   ACS Catalysis

Recent Advances in Polymer-Based Metal-Free Room-Temperature Phosphorescent Materials

(2018) Nan Gan et al.   ADVANCED FUNCTIONAL MATERIALS

Palladium-Catalyzed C−H Alkenylation of Arenes with Alkynes: Stereoselective Synthesis of Vinyl Chlorides via a 1,4-Chlorine Migration

(2018) Zhen Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The History of Palladium-Catalyzed Cross-Couplings Should Inspire the Future of Catalyst-Transfer Polymerization

(2018) Amanda K. Leone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange

(2018) William J. Kerr et al.   ACS Catalysis

Burgess iridium(I)-catalyst for selective hydrogen isotope exchange

(2017) Annina Burhop et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Oxidatively Induced C–H Activation at High Valent Nickel

(2017) Eugene Chong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo

(2017) Aaron R. Navratil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Development of a QuEChERS-Based Stable-Isotope Dilution LC-MS/MS Method To Quantitate Ferulic Acid and Its Main Microbial and Hepatic Metabolites in Milk

(2016) Martin Waterstraat et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Palladium-Catalyzed, Site-Selective Direct Allylation of Aryl C–H Bonds by Silver-Mediated C–H Activation: A Synthetic and Mechanistic Investigation

(2016) Sarah Yunmi Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

MIDA boronates are hydrolysed fast and slow by two different mechanisms

(2016) Jorge A. Gonzalez et al.   Nature Chemistry

Rational Molecular Design for Achieving Persistent and Efficient Pure Organic Room-Temperature Phosphorescence

(2016) Weijun Zhao et al.   Chem

Afterglow Organic Light-Emitting Diode

(2015) Ryota Kabe et al.   ADVANCED MATERIALS

Transformation of Step-Growth Polymerization into Living Chain-Growth Polymerization

(2015) Tsutomu Yokozawa et al.   CHEMICAL REVIEWS

Gold-Catalyzed Proto- and Deuterodeboronation

(2015) Graeme Barker et al.   JOURNAL OF ORGANIC CHEMISTRY

C–H arylation of triphenylene, naphthalene and related arenes using Pd/C

(2015) Karl D. Collins et al.   Chemical Science

Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

(2015) Hong-Hai Zhang et al.   Organic Chemistry Frontiers

Palladium-Catalyzed Trifluoromethylthiolation of Aryl C–H Bonds

(2014) Chunfa Xu et al.   ORGANIC LETTERS

Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties

(2014) Yanmei Zhang et al.   ACS Medicinal Chemistry Letters

The isotopic effects of deuteration on optoelectronic properties of conducting polymers

(2014) Ming Shao et al.   Nature Communications

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Arene–Metal π-Complexation as a Traceless Reactivity Enhancer for C–H Arylation

(2013) Paolo Ricci et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalyzed oxidative coupling of arylboronic acids with benzene derivatives through homolytic aromatic substitution

(2011) Nanase Uchiyama et al.   CHEMICAL COMMUNICATIONS

Stereochemistry and Mechanism of the Brønsted Acid Catalyzed Intramolecular Hydrofunctionalization of an Unactivated Cyclic Alkene

(2011) Rachel E. McKinney Brooner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Direct Arylation of Polycyclic Aromatic Hydrocarbons through Palladium Catalysis

(2011) Kenji Mochida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Platinum and Palladium Complexes Containing Cationic Ligands as Catalysts for Arene H/D Exchange and Oxidation

(2010) Marion H. Emmert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Isotope Effects in Asymmetric Reactions

(2010) Thomas Giagou et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed hydrogen isotope exchange labelling: a brief overview

(2010) William J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Isotope effect in spin response of π-conjugated polymer films and devices

(2010) Tho D. Nguyen et al.   NATURE MATERIALS

Cryptocatalytic 1,2-Alkene Migration in a σ-Alkyl Palladium Diene Complex

(2009) Louise A. Evans et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Suzuki Polycondensation: Polyarylenes à la Carte

(2009) Junji Sakamoto et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Big interest in heavy drugs

(2009) Katharine Sanderson   NATURE

Iridium‐Catalyzed H/D Exchange at Vinyl Groups without Olefin Isomerization

(2008) Jianrong Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient and Selective Pt/C-Catalyzed H–D Exchange Reaction of Aromatic Rings

(2008) Nobuhiro Ito et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

A Practical Method For Stabilizing Lithiated Halogenated Aromatic Compounds

(2008) Thimma Rawalpally et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT