Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α‐Fluoroketones

Catalytic Enantioselective Aldol‐type Reaction Using α‐Fluorinated Enolates

(2019) Yi Gong et al.   Asian Journal of Organic Chemistry

Internally reuse by-product as promoter: A catalyst-free imine formation/Mukaiyama-Mannich sequence of α-amido sulfones with fluorinated silyl enol ethers

(2019) Xiao-Si Hu et al.   JOURNAL OF FLUORINE CHEMISTRY

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

(2018) Yi Zhu et al.   CHEMICAL REVIEWS

Metal-Free Catalytic Asymmetric Fluorination of Keto Esters Using a Combination of Hydrogen Fluoride (HF) and Oxidant: Experiment and Computation

(2018) Roman Pluta et al.   ACS Catalysis

Organocatalytic Biomimetic Decarboxylative Aldol Reaction of Fluorinated β-Keto Acids with Unprotected Isatins

(2018) Yin-Long Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Carbon-Selective Difluoromethylation of Soft Carbon Nucleophiles with Difluoromethylated Sulfonium Ylide

(2018) Jiansheng Zhu et al.   CHINESE JOURNAL OF CHEMISTRY

An efficient Fe(III)-catalyzed 1,6-conjugate addition of para-quinone methides with fluorinated silyl enol ethers toward β,β-diaryl α-fluorinated ketones

(2018) Yong-Jia Hao et al.   TETRAHEDRON

Stereoselective Synthesis of Pyrrolidines Containing a 3-Fluoro Quaternary Stereocenter via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

(2017) Yang-Zi Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-Type Reaction

(2017) Bo Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Improved Fmoc Solid-Phase Peptide Synthesis of Oxytocin with High Bioactivity

(2017) Bi-Huang Hu et al.   SYNLETT

Reagent-controlled enantioselectivity switch for the asymmetric fluorination of β-ketocarbonyls by chiral primary amine catalysis

(2017) Yang'en You et al.   Chemical Science

A general and efficient Lewis acid catalysed Mukaiyama-aldol reaction of difluoroenoxysilanes and ketones

(2017) Fu-Min Liao et al.   Science Bulletin

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Enantioselective aldol reactions with masked fluoroacetates

(2016) Jakub Saadi et al.   Nature Chemistry

Organocatalytic enantioselective Mukaiyama–Mannich reaction of fluorinated enol silyl ethers and cyclic N-sulfonyl ketimines

(2016) Jin-Sheng Yu et al.   Organic Chemistry Frontiers

Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

(2015) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assembly of Fluorinated Quaternary Stereogenic Centers through Catalytic Enantioselective Detrifluoroacetylative Aldol Reactions

(2015) Chen Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of Hydrogen-Bonding Acceptors in Organo-Enamine Catalysis

(2015) Junbin Han et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides

(2015) Lennart Brewitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

(2015) Fu-Min Liao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorinated enol ethers: their synthesis and reactivity

(2015) M. Decostanzi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A highly efficient Mukaiyama–Mannich reaction of N-Boc isatin ketimines and other active cyclic ketimines using difluoroenol silyl ethers catalyzed by Ph3PAuOTf

(2015) Jin-Sheng Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mild and selective α-fluorination of carbonyl compounds (ketones, 1,3-diketones, β-ketoesters, α-nitroketones, and β-ketonitriles) with Selectfluor (F-TEDA-BF4) in imidazolium ILs [BMIM/PF6 or BMIM/NTf2] with Brønsted-acidic IL [PMIM(SO3H)/OTf] as promoter

(2015) A. Srinivas Reddy et al.   TETRAHEDRON LETTERS

Highly Efficient “On Water” Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects

(2014) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

(2014) Ying Huang et al.   CHEMICAL COMMUNICATIONS

Progress in Catalytic Asymmetric Protonation

(2014) Sylvain Oudeyer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Pd-Catalyzed Allylation of Acyclic α-Fluorinated Ketones

(2014) Wengui Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of α-Trifluoromethyl Ketones via the Cu-Catalyzed Trifluoromethylation of Silyl Enol Ethers Using an Electrophilic Trifluoromethylating Agent

(2014) Lun Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-Promoted Asymmetric Imino-Reformatsky Reaction of Ethyl Dibromofluoroacetate

(2014) Atsushi Tarui et al.   ORGANIC LETTERS

Iodoarene-catalyzed fluorination and aminofluorination by an Ar-I/HF·pyridine/mCPBA system

(2014) Satoru Suzuki et al.   Chemical Science

Highly stereoselective construction of adjacent tetrasubstituted carbon stereogenic centres via an organocatalytic Mukaiyama-aldol reaction of monofluorinated silyl enol ethers to isatins

(2014) Yun-Lin Liu et al.   Organic Chemistry Frontiers

Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α-Fluorinatedgem-Diols toN-Benzyl Isatins

(2013) Ibrayim Saidalimu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Highly Enantioselective Organocatalytic Asymmetric Mukaiyama-aldol Reaction of Difluoroenoxysilanes withβ,γ-Unsaturatedα-Ketoesters

(2012) Yunlin Liu et al.   ACTA CHIMICA SINICA

Asymmetric H–D exchange reactions of fluorinated aromatic ketones

(2012) Yujun Zhao et al.   CHEMICAL COMMUNICATIONS

Ethylene Glycol: A Powerful Catalyst-Free Medium for CC Bond-Forming Reactions

(2012) Yun-Lin Liu et al.   Chemistry-An Asian Journal

The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination

(2011) Lian Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

(2011) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Fluorinated Aromatic Ketones as Nucleophiles in the Asymmetric Organocatalytic Formation of CC and CN Bonds: A Facile Route to the Construction of Fluorinated Quaternary Stereogenic Centers

(2011) Yujun Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, Synthesis, and Applications of Potential Substitutes of t-Bu-Phosphinooxazoline in Pd-Catalyzed Asymmetric Transformations and Their Use for the Improvement of the Enantioselectivity in the Pd-Catalyzed Allylation Reaction of Fluorinated Allyl Enol Carbonates

(2011) Étienne Bélanger et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Organocatalyzed Enantioselective Protonation of Silyl Enol Ethers: Scope, Limitations, and Application to the Preparation of Enantioenriched Homoisoflavones

(2010) Thomas Poisson et al.   JOURNAL OF ORGANIC CHEMISTRY

Impact of Silyl Enol Ether Stability on Palladium-Catalyzed Arylations

(2010) Yong Guo et al.   ORGANOMETALLICS

(Thio)urea organocatalysis—What can be learnt from anion recognition?

(2009) Zhiguo Zhang et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective protonation

(2009) Justin T. Mohr et al.   Nature Chemistry

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

Asymmetric Malonic and Acetoacetic Acid Syntheses - A Century of Enantioselective Decarboxylative Protonations

(2008) Jérôme Blanchet et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

(2007) Ngoc T. Vo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY