Remote Site‐Selective Radical C(sp 3 )−H Monodeuteration of Amides using D 2 O

A Divergent Strategy for Site‐Selective Radical Disulfuration of Carboxylic Acids with Trisulfide‐1,1‐Dioxides

(2021) Zijun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N‐Centered Radical Directed Remote C−H Bond Functionalization via Hydrogen Atom Transfer

(2020) Gautam Kumar et al.   Chemistry-An Asian Journal

Base metal-catalyzed hydrogen isotope exchange

(2020) Haifeng Yang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach

(2020) Yueteng Zhang et al.   ACS Catalysis

Visible-light promoted regioselective amination and alkylation of remote C(sp3)-H bonds

(2020) Quanping Guo et al.   Nature Communications

Carbene-Catalyzed α,γ-Deuteration of Enals under Oxidative Conditions

(2020) Xiaolei Zhang et al.   ACS Catalysis

Copper‐Catalyzed Remote Direct Thiocyanation of Alkyl C(sp3)–H Bonds

(2020) Qian Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties

(2020) Enzo Nobile et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Room‐temperature Palladium‐Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals

(2020) Wei Ou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Remote C(sp3 )−H Trifluoromethylation of Carboxamides and Sulfonamides

(2019) Zhonglin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic α-Selective Deuteration of Styrene Derivatives

(2019) Thomas R. Puleo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

40 Years of Hydrogen–Deuterium Exchange Adjacent to Heteroatoms: A Survey

(2019) Maxime Roche et al.   SYNTHESIS-STUTTGART

Diversity-oriented Desulfonylative Functionalization of Alkyl Allyl Sulfones

(2019) Yong Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti‐Markovnikov Radical Hydro‐ and Deuteroamidation of Unactivated Alkenes

(2019) Heng Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Iridium(I) Catalysis towards Directed Hydrogen Isotope Exchange

(2019) William J. Kerr et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Copper-Catalyzed, N-Directed Csp3–H Trifluoromethylthiolation (−SCF3) and Trifluoromethylselenation (−SeCF3)

(2019) Atanu Modak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed, Chloroamide-Directed Benzylic C–H Difluoromethylation

(2019) Xiaojun Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

(2019) Zhen-Hua Zhang et al.   Nature Communications

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

(2018) J. Luke Koniarczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote C–H Functionalization via Selective Hydrogen Atom Transfer

(2018) David Nagib et al.   SYNTHESIS-STUTTGART

Hydrogen/Deuterium (H/D) Exchange Catalysis in Alkanes

(2018) Aaron Sattler   ACS Catalysis

A General Approach to Site-Specific, Intramolecular C−H Functionalization Using Dithiocarbamates

(2018) Christina G. Na et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Arylation of Remote C(sp3 )−H Bonds in Carboxamides and Sulfonamides

(2018) Zhaodong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

(2018) Sara P. Morcillo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Remote Radical C−H Functionalization of Unactivated C−H Bonds in Amides Using Sulfone Reagents

(2018) Yong Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Remote Site-Specific Radical Alkynylation of Unactivated C–H Bonds

(2018) Lin Wang et al.   ORGANIC LETTERS

Electrochemical-Oxidation-Induced Site-Selective Intramolecular C(sp3)–H Amination

(2018) Xia Hu et al.   ACS Catalysis

Catalytic C1  Alkylation with Methanol and Isotope-Labeled Methanol

(2018) Jan Sklyaruk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxygenative Deuteration of Carboxylic Acids with D2 O

(2018) Muliang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange

(2018) William J. Kerr et al.   ACS Catalysis

Radical Deuteration with D2O: Catalysis and Mechanistic Insights

(2017) Valentin Soulard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Triiodide-Mediated δ-Amination of Secondary C−H Bonds

(2016) Ethan A. Wappes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amide-directed photoredox-catalysed C–C bond formation at unactivated sp3 C–H bonds

(2016) John C. K. Chu et al.   NATURE

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Catalytic alkylation of remote C–H bonds enabled by proton-coupled electron transfer

(2016) Gilbert J. Choi et al.   NATURE

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Synthesis of Lactones via C–H Functionalization of Nonactivated C(sp3)–H Bonds

(2016) Johannes Richers et al.   ORGANIC LETTERS

Selective α-Deuteration of Amines and Amino Acids Using D2O

(2016) Basujit Chatterjee et al.   ORGANIC LETTERS

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

(2016) Joshua R. Dunetz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

γ,δ,ε-C(sp3)–H Functionalization through Directed Radical H-Abstraction

(2015) Tao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiyl Radicals in Organic Synthesis

(2014) Fabrice Dénès et al.   CHEMICAL REVIEWS

sp3 C–H oxidation by remote H-radical shift with oxygen- and nitrogen-radicals: a recent update

(2014) Shunsuke Chiba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Measuring Kinetic Isotope Effects in Enzyme Reactions Using Time-Resolved Electrospray Mass Spectrometry

(2013) Peter Liuni et al.   ANALYTICAL CHEMISTRY

Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

(2013) Grégory Pieters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

A robustness screen for the rapid assessment of chemical reactions

(2013) Karl D. Collins et al.   Nature Chemistry

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Catalytic H/D Exchange of Unactivated Aliphatic C–H Bonds

(2013) Sun Hwa Lee et al.   ORGANOMETALLICS

Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols

(2013) Eugene Khaskin et al.   ACS Catalysis

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms

(2011) Mar Gómez-Gallego et al.   CHEMICAL REVIEWS

Total Synthesis of Oxidized Welwitindolinones and (−)-N-Methylwelwitindolinone C Isonitrile

(2011) Kyle W. Quasdorf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Carboxylic Acids as Substrates in Homogeneous Catalysis

(2008) Lukas J. Gooßen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies

(2008) Abdul E. Mutlib   CHEMICAL RESEARCH IN TOXICOLOGY

Recent progress in the generation and use of nitrogen-centred radicals

(2008) Samir Z. Zard   CHEMICAL SOCIETY REVIEWS