标题
Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules
作者
关键词
-
出版物
CHEMICAL REVIEWS
Volume -, Issue -, Pages -
出版商
American Chemical Society (ACS)
发表日期
2022-02-18
DOI
10.1021/acs.chemrev.1c00795
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- A Facile Synthesis of Isotope Labeled Acylcarnitines
- (2021) Xiaojun Dai et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of α-Deuterated Primary Amines via Reductive Deuteration of Oximes Using D2O as a Deuterium Source
- (2021) Lei Ning et al. JOURNAL OF ORGANIC CHEMISTRY
- Cobalt-Catalyzed Protodeboronation of Aryl and Vinyl Boronates
- (2021) Ninglin Li et al. JOURNAL OF ORGANIC CHEMISTRY
- Excited-State Palladium-Catalyzed 1,2-Spin-Center Shift Enables Selective C-2 Reduction, Deuteration, and Iodination of Carbohydrates
- (2021) Gaoyuan Zhao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization
- (2021) Qi-Kai Kang et al. SYNLETT
- Visible-light-mediated deuteration of aldehydes with D2O via polarity-matched reversible hydrogen atom transfer
- (2021) Jian-Yang Dong et al. TETRAHEDRON
- A practical and efficient method for late-stage deuteration of terminal alkynes with silver salt as catalyst
- (2021) Ding-Chuan Wu et al. TETRAHEDRON LETTERS
- Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis
- (2021) Adrian Tlahuext-Aca et al. ACS Catalysis
- Site-Selective Silver-Catalyzed C–H Bond Deuteration of Five-Membered Aromatic Heterocycles and Pharmaceuticals
- (2021) Adrian Tlahuext-Aca et al. ACS Catalysis
- Nanocatalyzed Hydrogen Isotope Exchange
- (2021) Marco Lepron et al. ACCOUNTS OF CHEMICAL RESEARCH
- Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes
- (2021) Linwei Huang et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of Multideuterated (Hetero)aryl Bromides by Ag(I)-Catalyzed H/D Exchange
- (2021) Guang-Qi Hu et al. ORGANIC LETTERS
- Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water
- (2021) Jack S. Rowbotham et al. ACS Catalysis
- Mechanism of the Arene‐Limited Nondirected C–H Activation of Arenes with Palladium
- (2021) Philipp Wedi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes
- (2021) Zoua Pa Vang et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ruthenium‐catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group
- (2021) Sara Kopf et al. CHEMISTRY-A EUROPEAN JOURNAL
- Reduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides
- (2021) Bhagat Singh et al. JOURNAL OF ORGANIC CHEMISTRY
- Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy
- (2021) Zoua Pa Vang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-Catalyzed Photodehalogenation of Aryl Bromides
- (2021) Ruben Martin et al. SYNLETT
- Harnessing ynamide activation to access deuterated carbonyls
- (2021) Vincent Porte et al. TETRAHEDRON
- Protecting Benzylic CH Bonds by Deuteration Doubles the Operational Lifetime of Deep‐Blue Ir‐Phenylimidazole Dopants in Phosphorescent OLEDs
- (2021) Hye Jin Bae et al. Advanced Optical Materials
- Remote Site‐Selective Radical C(sp 3 )−H Monodeuteration of Amides using D 2 O
- (2021) Lin Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ambient Hydrogenation and Deuteration of Alkenes Using a Nanostructured Ni‐Core–Shell Catalyst
- (2021) Jie Gao et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Deuterated “Magic Methyl” Group: A Guide to Site‐Selective Trideuteromethyl Incorporation and Labeling by Using CD 3 Reagents
- (2021) Joost Steverlynck et al. CHEMISTRY-A EUROPEAN JOURNAL
- Indium Tribromide‐Catalysed Transfer‐Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes
- (2021) Luomo Li et al. CHEMISTRY-A EUROPEAN JOURNAL
- Late-Stage β-C(sp3)–H Deuteration of Carboxylic Acids
- (2021) Alexander Uttry et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CF2DSO2Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation
- (2021) Junqing Liang et al. ORGANIC LETTERS
- Synthesis of α-Deuterioalcohols by Single-Electron Umpolung Reductive Deuteration of Carbonyls Using D2O as Deuterium Source
- (2021) Yuxia Hou et al. SYNLETT
- Base‐Catalyzed Selective Deuteration of Alkynes
- (2021) Shiv Kumar et al. Asian Journal of Organic Chemistry
- Additive‐Free Visible‐Light‐Mediated Hydro‐/Deuterodediazoniation of Arenediazonium Tetrafluoroborates in THF/THF‐ d 8
- (2021) Lian Yang et al. Asian Journal of Organic Chemistry
- Palladium-Catalyzed Nondirected Late-Stage C–H Deuteration of Arenes
- (2021) Mirxan Farizyan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration
- (2021) Santosh C. Gadekar et al. ACS Catalysis
- C−H Functionalization-Prediction of Selectivity in Iridium(I)-Catalyzed Hydrogen Isotope Exchange Competition Reactions
- (2020) Mégane Valero et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Base metal-catalyzed hydrogen isotope exchange
- (2020) Haifeng Yang et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C–H Arylation of Heteroarenes
- (2020) Qui-Hien Nguyen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions
- (2020) Noam I. Saper et al. Nature Chemistry
- Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
- (2020) Siyu Guo et al. ORGANIC LETTERS
- Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O
- (2020) Nengbo Zhu et al. ORGANIC LETTERS
- Synthesis of Enantioenriched α-Deuterated α-Amino Acids Enabled by an Organophotocatalytic Radical Approach
- (2020) Peng Ji et al. ORGANIC LETTERS
- Pentafluorophenyl Esters: Highly Chemoselective Ketyl Precursors for the Synthesis of α,α-Dideuterio Alcohols Using SmI2 and D2O as a Deuterium Source
- (2020) Hengzhao Li et al. ORGANIC LETTERS
- Regiodivergent DH or HD Addition to Alkenes: Deuterohydrogenation versus Hydrodeuterogenation
- (2020) Luomo Li et al. ORGANIC LETTERS
- Mesoionic Carbene–Iridium Complex Catalyzed Ortho-Selective Hydrogen Isotope Exchange of Anilines with High Functional Group Tolerance
- (2020) Wei Liu et al. ORGANIC LETTERS
- Water Compatible Hypophosphites-d2 Reagents: Deuteration Reaction via Deutero-deiodination in Aqueous Solution
- (2020) Zejin Song et al. ORGANIC LETTERS
- N-Heterocyclic Carbene Catalyzed Deuteration of Aldehydes in D2O
- (2020) Yoshinari Sawama et al. SYNLETT
- Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach
- (2020) Yueteng Zhang et al. ACS Catalysis
- The Natural Product Lepidiline A as an N-Heterocyclic Carbene Ligand Precursor in Complexes of the Type [Ir(cod)(NHC)PPh3)]X: Synthesis, Characterisation, and Application in Hydrogen Isotope Exchange Catalysis
- (2020) Alison R. Cochrane et al. Catalysts
- Iridium(I) Complexes with Anionic N‐Heterocyclic Carbene Ligands as Catalysts for H/D Exchange in Nonpolar Media
- (2020) Marvin Koneczny et al. ADVANCED SYNTHESIS & CATALYSIS
- Chemical‐Reductant‐Free Electrochemical Deuteration Reaction using Deuterium Oxide
- (2020) Xu Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deuterium Exchange between Arenes and Deuterated Solvents in the Absence of a Transition Metal: Synthesis of D-Labeled Fluoroarenes
- (2020) Vanesa Salamanca et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- S-(4-Nitrobenzyl)-6-thioinosine: tritium labelling at high specific activity
- (2020) Crist N. Filer et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors
- (2020) Jonas Bergare et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Exhaustive Reduction of Esters Enabled by Nickel Catalysis
- (2020) Adam Cook et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Late-stage oxidative C(sp3)–H methylation
- (2020) Kaibo Feng et al. NATURE
- Preparation of cyclohexene isotopologues and stereoisotopomers from benzene
- (2020) Jacob A. Smith et al. NATURE
- Connecting remote C–H bond functionalization and decarboxylative coupling using simple amines
- (2020) Francisco de Azambuja et al. Nature Chemistry
- N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates
- (2020) Marc Magre et al. ORGANIC LETTERS
- Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis
- (2020) Giovanni Maestri et al. SYNTHESIS-STUTTGART
- Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
- (2020) J. S. Rowbotham et al. Nature Communications
- Diverse meta-C–H Functionalization of Amides
- (2020) Aniket Gholap et al. ACS Catalysis
- Carbene-Catalyzed α,γ-Deuteration of Enals under Oxidative Conditions
- (2020) Xiaolei Zhang et al. ACS Catalysis
- Bioinspired design of a robust d3-methylating agent
- (2020) Minyan Wang et al. Science Advances
- Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration
- (2020) Yong Wang et al. ADVANCED SYNTHESIS & CATALYSIS
- Electrocatalytic Deuteration of Halides with D2O as the Deuterium Source over a Copper Nanowire Arrays Cathode
- (2020) Cuibo Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Regiodivergent C–H and C–C Alkylation by Ruthenium Catalysis: ortho versus meta Position‐Selectivity
- (2020) Korkit Korvorapun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multiple Site Hydrogen Isotope Labelling of Pharmaceuticals
- (2020) Marion Daniel-Bertrand et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Tuning the Reactivity of a Heterogeneous Catalyst using N‐Heterocyclic Carbene Ligands for C‐H Activation Reactions
- (2020) Alberto Palazzolo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow
- (2020) Wai Chung Fu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Selective Transfer Semihydrogenation of Alkynes with H2O (D2O) as the H (D) Source over a Pd‐P Cathode
- (2020) Yongmeng Wu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Iodobenzene-catalyzed oxidative C H d-alkoxylation of quinoxalinones with deuterated alcohols
- (2020) Jianzhong Jin et al. CATALYSIS COMMUNICATIONS
- Photoredox‐mediated Hydrogen Isotope Exchange Reactions of Amino‐Acids, Peptides and Peptide‐derived drugs
- (2020) Fabien Legros et al. CHEMISTRY-A EUROPEAN JOURNAL
- Primary Vinyl Ethers as Acetylene Surrogate: A Flexible Tool for Deuterium-Labeled Pyrazole Synthesis
- (2020) Maria S. Ledovskaya et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Enantioselective synthesis of tri-deuterated (-)-geosmin to be used as internal standard in quantitation assays
- (2020) Caterina Porcelli et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
- (2020) Ahmed Haider et al. JOURNAL OF MEDICINAL CHEMISTRY
- Catalytic Hydrogenolysis of Aryl C–F Bonds Using a Bimetallic Rhodium–Indium Complex
- (2020) James T. Moore et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Streamlined Construction of Silicon-Stereogenic Silanes by Tandem Enantioselective C–H Silylation/Alkene Hydrosilylation
- (2020) Delong Mu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enhancement of a Heroin Vaccine through Hapten Deuteration
- (2020) Tyson F. Belz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A straightforward catalytic approach to obtain deuterated chloroform at room temperature
- (2020) Angel Ruben Higuera-Padilla et al. MAGNETIC RESONANCE IN CHEMISTRY
- Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange
- (2020) Jinquan Zhang et al. ACS Catalysis
- Hydrogen Isotope Exchange with Superbulky Alkaline Earth Metal Amide Catalysts
- (2020) Johannes Martin et al. ACS Catalysis
- Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters
- (2020) Stephanie W. Chun et al. ACS Catalysis
- C(sp2)–H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene-d6 as a Deuterium Source
- (2020) Javier Corpas et al. ACS Catalysis
- Iron(III)-Mediated Rapid Radical-Type Three-Component Deuteration of Quinoxalinones With Olefins and NaBD4
- (2020) Wanmei Li et al. Frontiers in Chemistry
- Electrolytic deuteration of unsaturated bonds without using D2
- (2020) Aiko Kurimoto et al. Nature Catalysis
- Iridium‐Catalysed Reductive Deoxygenation of Ketones with Formic Acid as Traceless Hydride Donor
- (2020) Zhiheng Yang et al. ADVANCED SYNTHESIS & CATALYSIS
- Direct β‐ and γ‐C(sp 3 )−H Alkynylation of Free Carboxylic Acids
- (2020) Francesca Ghiringhelli et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hydrogen Bond Donor Solvents Enabled Catalyst‐free (Radio)‐Halogenation and Deuteration of Organoborons
- (2020) Yi Yang et al. CHEMISTRY-A EUROPEAN JOURNAL
- Chemoselective Alpha‐Deuteration of Amides Via Retro‐ene Reaction
- (2020) Vincent Porte et al. CHEMISTRY-A EUROPEAN JOURNAL
- Shifted Selectivity in Protonation Enables the Mild Deuteration of Arenes Through Catalytic Amounts of Bronsted Acids in Deuterated Methanol
- (2020) Oliver Fischer et al. JOURNAL OF ORGANIC CHEMISTRY
- Rhodium-Catalyzed Atroposelective Oxidative C–H/C–H Cross-Coupling Reaction of 1-Aryl Isoquinoline Derivatives with Electron-Rich Heteroarenes
- (2020) Qiang Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Iron-Catalyzed Regiodivergent Alkyne Hydrosilylation
- (2020) Meng-Yang Hu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Facile H/D Exchange at (Hetero)Aromatic Hydrocarbons Catalyzed by a Stable Trans-Dihydride N-Heterocyclic Carbene (NHC) Iron Complex
- (2020) Subhash Garhwal et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-Catalyzed Asymmetric Transfer Hydrogenation and α-Selective Deuteration of N-Sulfonyl Imines with Alcohols: Access to α-Deuterated Chiral Amines
- (2020) Peng Yang et al. ORGANIC LETTERS
- Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation–Deuteration of Heterobenzylic Methylenes
- (2020) Yonghai Liu et al. ORGANIC LETTERS
- Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D2O as Deuterium Source
- (2020) Xiaodong Ma et al. SYNLETT
- Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
- (2020) Zhaofei Zhang et al. Nature Communications
- Computationally-Guided Development of a Chelated NHC-P Iridium(I) Complex for the Directed Hydrogen Isotope Exchange of Aryl Sulfones
- (2020) William J. Kerr et al. ACS Catalysis
- Organocatalytic Deuteration Induced by the Dynamic Covalent Interaction of Imidazolium Cations with Ketones
- (2020) Konstantin I. Galkin et al. ADVANCED SYNTHESIS & CATALYSIS
- Room‐temperature Palladium‐Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals
- (2020) Wei Ou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
- (2020) Robert W. Pipal et al. NATURE
- Breaking the Symmetry of a Meso Compound by Isotopic Substitution: Synthesis and Stereochemical Assignment of Monodeuterated cis-Perhydroazulene
- (2020) Fumito Saito et al. ORGANIC LETTERS
- Regioselective α-Deuteration of Michael Acceptors Mediated by Isopropylamine in D2O/AcOD
- (2020) Vinod G. Landge et al. ORGANIC LETTERS
- Scalable synthesis of the aroma compounds d6-β-ionone and d6-β-cyclocitral for use as internal standards in stable isotope dilution assays
- (2020) Shabnam Mosaferi et al. TETRAHEDRON LETTERS
- Facile and Economical Electrochemical Dehalogenative Deuteration of (Hetero)Aryl Halides
- (2020) Lijun Lu et al. CCS Chemistry
- Applications of deuterium in medicinal chemistry
- (2019) Tracey Pirali et al. JOURNAL OF MEDICINAL CHEMISTRY
- Catalytic α-Selective Deuteration of Styrene Derivatives
- (2019) Thomas R. Puleo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction
- (2019) Zuyuan Shen et al. ORGANIC LETTERS
- 40 Years of Hydrogen–Deuterium Exchange Adjacent to Heteroatoms: A Survey
- (2019) Maxime Roche et al. SYNTHESIS-STUTTGART
- Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols
- (2019) Jakapun Soponpong et al. TETRAHEDRON LETTERS
- H–D Exchange Deuteration of Arenes at Room Temperature
- (2019) Yoshinari Sawama et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Palladium Catalyzed Hydrodefluorination of Fluoro-(hetero)arenes
- (2019) Joseph J. Gair et al. ORGANIC LETTERS
- Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes
- (2019) Chuan-Qi Zhao et al. ORGANIC LETTERS
- Ni(I)–X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals
- (2019) Cayetana Zarate et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ir-Catalyzed Intermolecular Branch-Selective Allylic C–H Amidation of Unactivated Terminal Olefins
- (2019) Honghui Lei et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Diboron-Assisted Copper-Catalyzed Z-Selective Semihydrogenation of Alkynes Using Ethanol as a Hydrogen Donor
- (2019) Hanyang Bao et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat and human microsomes
- (2019) Xinmin Gan et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Ni-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines
- (2019) Bowen Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange
- (2019) Alberto Palazzolo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Diversity-oriented Desulfonylative Functionalization of Alkyl Allyl Sulfones
- (2019) Yong Xia et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Palladium‐Catalyzed Selective meta ‐C−H Deuteration of Arenes: Reaction Design and Applications
- (2019) Sukdev Bag et al. CHEMISTRY-A EUROPEAN JOURNAL
- Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides
- (2019) Mégane Valero et al. CHEMISTRY-A EUROPEAN JOURNAL
- Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2
- (2019) Markus Artelsmair et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Rhodium-Catalyzed Selective C–H Trideuteromethylation of Indole at C7 Position Using Acetic-d6 Anhydride
- (2019) Xiaowei Han et al. JOURNAL OF ORGANIC CHEMISTRY
- Palladium-Catalyzed Regioselective C–H Iodination of Unactivated Alkenes
- (2019) Benedikt Schreib et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Chemoenzymatic Synthesis of C6-Modified Sugar Nucleotides To Probe the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa
- (2019) Sanaz Ahmadipour et al. ORGANIC LETTERS
- Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium Carbide
- (2019) Maria Ledovskaya et al. SYNTHESIS-STUTTGART
- Cobalt‐Catalyzed Transfer Hydrogenation of α‐Ketoesters and N ‐Cyclicsulfonylimides Using H 2 O as Hydrogen Source
- (2019) Yang Gao et al. ADVANCED SYNTHESIS & CATALYSIS
- Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α‐Fluoroketones
- (2019) Kui Liao et al. CHINESE JOURNAL OF CHEMISTRY
- Highlights of aliphatic C (sp3 )-H Hydrogen Isotope Exchange Reactions
- (2019) Mégane Valero et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Tritiodefluorination of alkyl C-F groups
- (2019) Břetislav Brož et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Hydro/Deutero Deamination of Arylazo Sulfones under Metal- and (Photo)Catalyst-Free Conditions
- (2019) Hawraz I. M. Amin et al. MOLECULES
- Palladium-Catalyzed Remote meta-C–H Bond Deuteration of Arenes Using a Pyridine Template
- (2019) Hui Xu et al. ORGANIC LETTERS
- Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides
- (2019) Masami Kuriyama et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A primer of deuterium in drug design
- (2019) Sarah Cargnin et al. Future Medicinal Chemistry
- Highlights of C (sp2 )-H hydrogen isotope Exchange Reactions
- (2019) David Hesk JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Dehalogenative Deuteration of Unactivated Alkyl halides Using D2O as the Deuterium Source
- (2019) Aiyou Xia et al. JOURNAL OF ORGANIC CHEMISTRY
- Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C–H Bonds of Drug Molecules
- (2019) Yejin Chang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ag2CO3-Catalyzed H/D Exchange of Five-Membered Heteroarenes at Ambient Temperature
- (2019) En-Ci Li et al. ORGANIC LETTERS
- A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII
- (2019) Alyssa L. Garreau et al. ORGANIC LETTERS
- Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides
- (2019) Ming-Hui Zhu et al. ORGANIC LETTERS
- Continuous‐Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α‐Dideutero Amines
- (2019) Rebeka Mészáros et al. ChemPlusChem
- Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
- (2019) Mégane Valero et al. ChemistryOpen
- Synthesis of anti-vicinal diboronates from diarylethynes and B2pin2
- (2019) Zhijie Kuang et al. Science Bulletin
- Mesoionic Carbene (MIC)-Catalyzed H/D Exchange at Formyl Groups
- (2019) Wei Liu et al. Chem
- Palladium-Borane Cooperation: Evidence for an Anionic Pathway and Its Application to Catalytic Hydro-/Deutero-dechlorination
- (2019) Hajime Kameo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mild, Selective Ru‐Catalyzed Deuteration Using D 2 O as a Deuterium Source
- (2019) Pascal Eisele et al. CHEMISTRY-A EUROPEAN JOURNAL
- Recent Advances in Iridium(I) Catalysis towards Directed Hydrogen Isotope Exchange
- (2019) William J. Kerr et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Reductive Deuteration of Nitriles Using D2O as a Deuterium Source
- (2019) Yuxuan Ding et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of Benzylic Alcohols by C–H Oxidation
- (2019) Lalita Tanwar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-Tunable Csp3–H Bonds Functionalization by Visible-Light-Induced Radical Translocation of N-Alkoxyphthalimides
- (2019) Chuanyong Wang et al. ORGANIC LETTERS
- Scalable Synthesis of Acridinium Catalysts for Photoredox Deuterations
- (2019) Bouthayna Zilate et al. SYNTHESIS-STUTTGART
- Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis
- (2019) Huihui Geng et al. Nature Catalysis
- B(C 6 F 5 ) 3 ‐Catalyzed α ‐Deuteration of Bioactive Carbonyl Compounds with D 2 O
- (2019) Yejin Chang et al. ADVANCED SYNTHESIS & CATALYSIS
- NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines
- (2019) Mégane Valero et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation
- (2019) Valentin Müller et al. ChemCatChem
- Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N‐Heterocycles and Reaction Mechanism Insights
- (2019) Grégory Pieters et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ruthenium-Catalyzed ortho- and meta-H/D Exchange of Arenes
- (2019) Liang-Liang Zhao et al. ORGANIC LETTERS
- New Dopamine D2 Receptor Agonist, [3H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo
- (2018) Sivan Subburaju et al. ACS Chemical Neuroscience
- Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides
- (2018) Mégane Valero et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water-Gas Shift Reaction
- (2018) Malek Y. S. Ibrahim et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences
- (2018) Jens Atzrodt et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals
- (2018) Haifeng Yang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Selective α-Monomethylation by an Amine-Borane/N,N-Dimethylformamide System as the Methyl Source
- (2018) Hui-Min Xia et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- C−H Functionalisation for Hydrogen Isotope Exchange
- (2018) Jens Atzrodt et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)–H bonds directed by a sulfur atom
- (2018) Longhui Gao et al. CHEMICAL COMMUNICATIONS
- Ruthenium-catalyzed selective α-deuteration of aliphatic nitriles using D2O
- (2018) Varadhan Krishnakumar et al. CHEMICAL COMMUNICATIONS
- Metal-free Halogen(I) Catalysts for Oxidation of (Aryl)(heteroaryl)-methanes to Ketones or Esters : Selectivity Control by Halogen Bond
- (2018) SOMRAJ GUHA et al. CHEMISTRY-A EUROPEAN JOURNAL
- DMSO as a Switchable Alkylating Agent in Heteroarene C−H Functionalization
- (2018) R. Aleyda Garza-Sanchez et al. CHEMISTRY-A EUROPEAN JOURNAL
- Reductive Cleavage Method for Quantitation of Monolignols and Low-Abundance Monolignol Conjugates
- (2018) Matt Regner et al. ChemSusChem
- Enantioselective Deuteration of β-Substituted α,β-Unsaturated Esters by Rhodium-1,2-Bis(2,5-diphenylphospholano)ethane
- (2018) Sébastien Lethu et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Regioselective deuteration of alcohols in D2O catalysed by homogeneous manganese and iron pincer complexes
- (2018) Sayan Kar et al. GREEN CHEMISTRY
- Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds
- (2018) Mégane Valero et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of stable isotope-labeled nasturlexins and potential precursors to probe biosynthetic pathways of cruciferous phytoalexins
- (2018) M. Soledade C. Pedras et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of 3 H, 13 C2 , 2 H4 14 C-SCH 430765 and 35 S-SCH 500946, potent and selective inhibitors of the NPY5 receptor
- (2018) D. Hesk et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Reduction and Reductive Deuteration of Tertiary Amides Mediated by Sodium Dispersions with Distinct Proton Donor-Dependent Chemoselectivity
- (2018) Bin Zhang et al. JOURNAL OF ORGANIC CHEMISTRY
- Palladium-Catalyzed Regioselective C–H Functionalization of Arenes Substituted by Two N-Heterocycles and Application in Late-Stage Functionalization
- (2018) Da-Wei Yin et al. JOURNAL OF ORGANIC CHEMISTRY
- Method for Small-Scale Production of Deuterochloroform
- (2018) Natha D. Tansukawat et al. JOURNAL OF ORGANIC CHEMISTRY
- Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids
- (2018) Donghong Zhao et al. JOURNAL OF ORGANIC CHEMISTRY
- [3 + 2]-Cycloaddition of in Situ Generated Nitrile Imines and Acetylene for Assembling of 1,3-Disubstituted Pyrazoles with Quantitative Deuterium Labeling
- (2018) Vladimir V. Voronin et al. JOURNAL OF ORGANIC CHEMISTRY
- Carbon Dioxide-Mediated C(sp3)–H Arylation of Amine Substrates
- (2018) Mohit Kapoor et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals
- (2018) J. Luke Koniarczyk et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide
- (2018) Yang Geng et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Transition-Metal-Free, Selective Reductive Deuteration of Terminal Alkynes with Sodium Dispersions and EtOD-d1
- (2018) Minhui Han et al. ORGANIC LETTERS
- One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides
- (2018) Xiangmin Li et al. ORGANIC LETTERS
- Palladium-catalyzed site-selective hydrogen isotope exchange (HIE) reaction of arylsulfonamides using amino acid auxiliary
- (2018) Wei Liu et al. TETRAHEDRON
- Controllable deuteration of halogenated compounds by photocatalytic D2O splitting
- (2018) Cuibo Liu et al. Nature Communications
- Hydrogen/Deuterium (H/D) Exchange Catalysis in Alkanes
- (2018) Aaron Sattler ACS Catalysis
- Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation
- (2018) Maria S. Ledovskaya et al. Organic Chemistry Frontiers
- Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation
- (2018) Shan Tang et al. Chem
- Iron-Mediated Azidomethylation or Azidotrideuteromethylation of Active Alkenes with Azidotrimethylsilane and Dimethyl Sulfoxide
- (2018) Rui Zhang et al. ADVANCED SYNTHESIS & CATALYSIS
- Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in Deuterium Oxide
- (2018) Kwihwan Park et al. ADVANCED SYNTHESIS & CATALYSIS
- Copper-Catalyzed Arylation of Remote C(sp3 )−H Bonds in Carboxamides and Sulfonamides
- (2018) Zhaodong Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions
- (2018) Yuxuan Ding et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol2
- (2018) Rita Sigüeiro et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- General and Practical Potassium Methoxide/Disilane-Mediated Dehalogenative Deuteration of (Hetero)Arylhalides
- (2018) Xin Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Copper-Catalyzed Electrochemical C–H Amination of Arenes with Secondary Amines
- (2018) Qi-Liang Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals
- (2018) Haifeng Yang et al. ACS Catalysis
- Catalytic C1 Alkylation with Methanol and Isotope-Labeled Methanol
- (2018) Jan Sklyaruk et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deoxygenative Deuteration of Carboxylic Acids with D2 O
- (2018) Muliang Zhang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Biphasic Medium Slows Down the Transfer Hydrogenation and Allows a Selective Catalytic Deuterium Labeling of Amines from Imines Mediated by a Ru−H/D + Exchange in D 2 O
- (2018) Margarita Ruiz‐Castañeda et al. ChemCatChem
- Ruthenium(II)biscarboxylate-Catalyzed Hydrogen-Isotope Exchange by Alkene C−H Activation
- (2018) Alexander Bechtoldt et al. ChemCatChem
- Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen
- (2018) Felix Pape et al. CHEMISTRY-A EUROPEAN JOURNAL
- Room Temperature Iron-Catalyzed Transfer Hydrogenation and Regioselective Deuteration of Carbon–Carbon Double Bonds
- (2018) Maialen Espinal-Viguri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Regioselective Transfer Hydrodeuteration of Alkenes with a Hydrogen Deuteride Surrogate Using B(C6F5)3 Catalysis
- (2018) Johannes C. L. Walker et al. ORGANIC LETTERS
- Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange
- (2018) William J. Kerr et al. ACS Catalysis
- Convenient Method for the Production of Deuterium Gas Catalyzed by an Iridium Complex and Its Application to the Deuteration of Organic Compounds
- (2018) Akane Enomoto et al. CHEMISTRY LETTERS
- Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts
- (2017) Annina Burhop et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Deuterated drugs; updates and obviousness analysis
- (2017) Graham S. Timmins EXPERT OPINION ON THERAPEUTIC PATENTS
- Quantitation of Rotundone in Grapefruit (Citrus paradisi) Peel and Juice by Stable Isotope Dilution Assay
- (2017) Akira Nakanishi et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Synthesis of3H,2H4, and14C-MK 3814 (preladenant)
- (2017) D. Hesk et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor
- (2017) Yinsheng Zhang JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Convergent synthesis of a deuterium-labeled serine dipeptide lipid for analysis of biological samples
- (2017) Christopher Dietz et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Burgess iridium(I)-catalyst for selective hydrogen isotope exchange
- (2017) Annina Burhop et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Organocatalytic Imidazolium Ionic Liquids H/D Exchange Catalysts
- (2017) Marcileia Zanatta et al. JOURNAL OF ORGANIC CHEMISTRY
- Development of a Modified Bouveault–Blanc Reduction for the Selective Synthesis of α,α-Dideuterio Alcohols
- (2017) Minhui Han et al. JOURNAL OF ORGANIC CHEMISTRY
- Site-Specific Deuteration of Polyunsaturated Alkenes
- (2017) A. V. Smarun et al. JOURNAL OF ORGANIC CHEMISTRY
- Radical Deuteration with D2O: Catalysis and Mechanistic Insights
- (2017) Valentin Soulard et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- First deuterated drug approved
- (2017) Charles Schmidt NATURE BIOTECHNOLOGY
- Asymmetric synthesis of α-deuterated α-amino acids
- (2017) Ryosuke Takeda et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes
- (2017) Min Liu et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- B(C6F5)3-Catalyzed Regioselective Deuteration of Electron-Rich Aromatic and Heteroaromatic Compounds
- (2017) Wu Li et al. ORGANIC LETTERS
- Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C–H Nitration of Arenes with Removable Auxiliaries
- (2017) Zhoulong Fan et al. ORGANIC LETTERS
- Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
- (2017) Yong Yao Loh et al. SCIENCE
- Catalytic Deuteration of Aldehydes with D2O
- (2017) Stephen Newman et al. SYNLETT
- A selective and cost-effective method for the reductive deuteration of activated alkenes
- (2017) Hengzhao Li et al. TETRAHEDRON LETTERS
- Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps
- (2017) Munia F. Sowaileh et al. TETRAHEDRON LETTERS
- Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds
- (2017) W. Neil Palmer et al. ACS Catalysis
- Site-Selective Deuteration of N-Heterocycles via Iridium-Catalyzed Hydrogen Isotope Exchange
- (2017) William J. Kerr et al. ACS Catalysis
- Free-radical initiated cascade methylation or trideuteromethylation of isocyanides with dimethyl sulfoxides
- (2017) Rui Zhang et al. RSC Advances
- Efficient Brønsted-Acid-Catalyzed Deuteration of Arenes and Their Transformation to Functionalized Deuterated Products
- (2017) Xuewei Liang et al. Asian Journal of Organic Chemistry
- Nickel-Catalyzed Deoxygenative Deuteration of Aryl Sulfamates
- (2016) Masami Kuriyama et al. ADVANCED SYNTHESIS & CATALYSIS
- Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles
- (2016) William J. Kerr et al. CHEMICAL COMMUNICATIONS
- Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks
- (2016) Roberta Caporaso et al. CHEMICAL COMMUNICATIONS
- The ruthenium-catalysed selective synthesis of mono-deuterated terminal alkynes
- (2016) Basujit Chatterjee et al. CHEMICAL COMMUNICATIONS
- AVP-786 for the treatment of agitation in dementia of the Alzheimer’s type
- (2016) Ricardo P. Garay et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study
- (2016) William J. Kerr et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors
- (2016) Paul Allen et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP)
- (2016) Åsa Lindelöf et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Ag(I)-Catalyzed C–H Activation: The Role of the Ag(I) Salt in Pd/Ag-Mediated C–H Arylation of Electron-Deficient Arenes
- (2016) Daniel Whitaker et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Stereoretentive Deuteration of α-Chiral Amines with D2O
- (2016) Lillian V. A. Hale et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Meta-Selective CAr–H Nitration of Arenes through a Ru3(CO)12-Catalyzed Ortho-Metalation Strategy
- (2016) Zhoulong Fan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Iron-catalysed tritiation of pharmaceuticals
- (2016) Renyuan Pony Yu et al. NATURE
- Selective H/D Exchange at Vinyl and Methylidene Groups with D2O Catalyzed by an Iridium Complex
- (2016) Miyuki Hatano et al. ORGANIC LETTERS
- Selective α-Deuteration of Amines and Amino Acids Using D2O
- (2016) Basujit Chatterjee et al. ORGANIC LETTERS
- Role of Silver Salts in Palladium-Catalyzed Arene and Heteroarene C–H Functionalization Reactions
- (2016) Monica D. Lotz et al. ORGANOMETALLICS
- Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds
- (2015) Soumitra Agasti et al. ADVANCED SYNTHESIS & CATALYSIS
- Directedmeta-Selective Bromination of Arenes with Ruthenium Catalysts
- (2015) Qingzhen Yu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols
- (2015) Miao Zhan et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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- (2015) Annelaure Damont et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Iridium-Catalysed ortho-Directed Deuterium Labelling of Aromatic Esters—An Experimental and Theoretical Study on Directing Group Chemoselectivity
- (2015) Jennifer Devlin et al. MOLECULES
- Ruthenium Catalyzed Selective α- and α,β-Deuteration of Alcohols Using D2O
- (2015) Basujit Chatterjee et al. ORGANIC LETTERS
- Isotopic Labelling of Functionalised Arenes Catalysed by Iridium(I) Species of the [(cod)Ir(NHC)(py)]PF6 Complex Class
- (2015) William Kerr et al. SYNLETT
- Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles
- (2015) Jens Atzrodt et al. TETRAHEDRON
- Hydrogen–deuterium exchange of aromatic amines and amides using deuterated trifluoroacetic acid
- (2015) Richard Giles et al. TETRAHEDRON LETTERS
- The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange
- (2014) Jack A. Brown et al. ADVANCED SYNTHESIS & CATALYSIS
- Iridium-Catalyzed H/D Exchange: Ligand Complexes with Improved Efficiency and Scope
- (2014) Michael Parmentier et al. CHEMISTRY-A EUROPEAN JOURNAL
- Iridium(I)-Catalyzed Regioselective CH Activation and Hydrogen-Isotope Exchange of Non-aromatic Unsaturated Functionality
- (2014) William J. Kerr et al. CHEMISTRY-A EUROPEAN JOURNAL
- Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
- (2014) Edon Vitaku et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regioselective ruthenium catalysed H–D exchange using D2O as the deuterium source
- (2014) Lorenzo Piola et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes
- (2014) A. R. Cochrane et al. ORGANIC & BIOMOLECULAR CHEMISTRY
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- (2014) Yanmei Zhang et al. ACS Medicinal Chemistry Letters
- Selective Catalytic Deuterium Labeling of Alcohols during a Transfer Hydrogenation Process of Ketones Using D2O as the Only Deuterium Source. Theoretical and Experimental Demonstration of a Ru–H/D+ Exchange as the Key Step
- (2014) M. Carmen Carrión et al. ACS Catalysis
- Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study
- (2014) William J. Kerr et al. ACS Catalysis
- Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions
- (2013) Heike Schönherr et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles
- (2013) Sandy Ma et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles
- (2013) Grégory Pieters et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2013) Paul W. Manley et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Application of neutral iridium(I)N-heterocyclic carbene complexes inortho-directed hydrogen isotope exchange
- (2013) Alison R. Cochrane et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
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- (2013) Matthew C. O’Reilly et al. JOURNAL OF MEDICINAL CHEMISTRY
- Using Deuterium in Drug Discovery: Leaving the Label in the Drug
- (2013) Thomas G. Gant JOURNAL OF MEDICINAL CHEMISTRY
- Heavy drugs draw heavy interest from pharma backers
- (2013) Alla Katsnelson NATURE MEDICINE
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- (2013) Yaoqiu Zhu et al. ACS Medicinal Chemistry Letters
- Simple and Efficient Catalytic Reaction for the Selective Deuteration of Alcohols
- (2013) Eugene Khaskin et al. ACS Catalysis
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- (2013) Ping Wang et al. Journal of Materials Chemistry C
- On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes
- (2012) Eric M. Simmons et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
- (2012) Yong-Kang Zhang et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Tritium: a coming of age for drug discovery and development ADME studies
- (2012) W. J. S. Lockley et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of Deuterated 1,2,3-Triazoles
- (2012) Hari K. Akula et al. JOURNAL OF ORGANIC CHEMISTRY
- Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines
- (2012) Lorenz Neubert et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mild Reaction Conditions for the Terminal Deuteration of Alkynes
- (2012) Sean P. Bew et al. ORGANIC LETTERS
- Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System
- (2012) Hironao Sajiki et al. SYNLETT
- Mild and Selective H/D Exchange at the β Position of Aromatic α-Olefins by N-Heterocyclic Carbene-Hydride-Rhodium Catalysts
- (2011) Andrea Di Giuseppe et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ruthenium-Catalyzed Regioselective Deuteration of Alcohols at the β-Carbon Position with Deuterium Oxide
- (2011) Sunny Kai San Tse et al. CHEMISTRY-A EUROPEAN JOURNAL
- (η6-Arene)ruthenium(N-heterocyclic carbene) Complexes for the Chelation-Assisted Arylation and Deuteration of Arylpyridines: Catalytic Studies and Mechanistic Insights
- (2010) Amparo Prades et al. ADVANCED SYNTHESIS & CATALYSIS
- Hydrogen/Deuterium Exchange Reactions of Olefins with Deuterium Oxide Mediated by the Carbonylchlorohydrido- tris(triphenylphosphine)ruthenium(II) Complex
- (2010) Sunny Kai San Tse et al. ADVANCED SYNTHESIS & CATALYSIS
- Deuteration isotope effect on nonradiative transition of fac-tris (2-phenylpyridinato) iridium (III) complexes
- (2010) Taichi Abe et al. CHEMICAL PHYSICS LETTERS
- Hydrogen exchange mass spectrometry for studying protein structure and dynamics
- (2010) Lars Konermann et al. CHEMICAL SOCIETY REVIEWS
- Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective
- (2010) Jens Atzrodt et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Metal-catalysed hydrogen isotope exchange labelling: a brief overview
- (2010) William J. S. Lockley et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Nickel-catalyzed hydrogen isotope exchange
- (2010) J. Richard Heys JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Tritium labelling of pharmaceuticals by metal-catalysed exchange methods
- (2010) D. Hesk et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Hydrogen isotope labelling using iridium(I) dionates
- (2010) W. J. S. Lockley JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Ni-Catalyzed Reduction of Inert C−O Bonds: A New Strategy for Using Aryl Ethers as Easily Removable Directing Groups
- (2010) Paula Álvarez-Bercedo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor
- (2009) Yossi Zafrani et al. TETRAHEDRON
- A Convenient and Effective Method for the Regioselective Deuteration of Alcohols
- (2008) Tomohiro Maegawa et al. ADVANCED SYNTHESIS & CATALYSIS
- Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal
- (2008) Tomohiro Maegawa et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Efficient and Selective Pt/C-Catalyzed H–D Exchange Reaction of Aromatic Rings
- (2008) Nobuhiro Ito et al. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- Highly active iridium(i) complexes for catalytic hydrogen isotope exchange
- (2008) Jack A. Brown et al. CHEMICAL COMMUNICATIONS
- Facile and Convenient Method of Deuterium Gas Generation Using a Pd/C-Catalyzed H2–D2 Exchange Reaction and Its Application to Synthesis of Deuterium-Labeled Compounds
- (2008) Takanori Kurita et al. CHEMISTRY-A EUROPEAN JOURNAL
- Quantification of malonylcarnitine in dried blood spots by use of MS/MS varies by stable isotope internal standard composition
- (2008) Donald H. Chace et al. CLINICA CHIMICA ACTA
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- (2008) Shirisha Komarapuri et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- A Simple, Cost-Effective Method for the Regioselective Deuteration of Anilines
- (2008) Andrew Martins et al. ORGANIC LETTERS
- H-D Exchange Reaction Taking Advantage of the Synergistic Effect of Heterogeneous Palladium and Platinum Mixed Catalyst
- (2008) Hironao Sajiki et al. SYNTHESIS-STUTTGART
- Efficient and Convenient Heterogeneous Palladium-Catalyzed Regioselective Deuteration at the Benzylic Position
- (2007) Takanori Kurita et al. CHEMISTRY-A EUROPEAN JOURNAL
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