A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes

Nickel-Catalyzed Methylation of Aryl Halides with Deuterated Methyl Iodide

(2016) Lu Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuteration enhances catalyst lifetime in palladium-catalysed alcohol oxidation

(2016) Nicola Armenise et al.   CHEMICAL COMMUNICATIONS

The ruthenium-catalysed selective synthesis of mono-deuterated terminal alkynes

(2016) Basujit Chatterjee et al.   CHEMICAL COMMUNICATIONS

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

(2016) Kevin W. Kuntz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

A Three-Component Approach to 3,5-Diaryl-1,2,4-thiadiazoles under Transition-Metal-Free Conditions

(2016) Hao Xie et al.   ORGANIC LETTERS

Copper-catalysed aerobic oxidative esterification of N-heteroaryl methanes with alcohols

(2016) Min Liu et al.   Catalysis Science & Technology

Transition metal-free oxidative ortho-acylation of phenols with N-heteroarylmethanes via double C–H activation

(2016) Min Liu et al.   Catalysis Science & Technology

Efficient 2-sulfolmethyl quinoline formation from 2-methylquinolines and sodium sulfinates under transition-metal free conditions

(2015) Fuhong Xiao et al.   CHEMICAL COMMUNICATIONS

Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)

(2015) Adrian L. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

(2015) Andrew T. Bockus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deuterative cyclization of sulfanyl 1,6-diynes: complete and monodeuteration of functional groups on heterocycles

(2015) Yukiteru Ito et al.   Organic Chemistry Frontiers

Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis

(2014) Jianming Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nucleic Acid Oxidation in DNA Damage Repair and Epigenetics

(2014) Guanqun Zheng et al.   CHEMICAL REVIEWS

Functionalization of the Benzylic C-H Bonds in Azaarenes by Cobalt-Catalyzed 1,4-Addition to Enones

(2014) Zaini Jamal et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

(2014) Dejan Caglič et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Aerobic Oxidative Amination of sp3C–H Bonds: Efficient Synthesis of 2-Hetarylquinazolin-4(3H)-ones

(2014) Qiang Li et al.   ORGANIC LETTERS

Selective Catalytic Deuterium Labeling of Alcohols during a Transfer Hydrogenation Process of Ketones Using D2O as the Only Deuterium Source. Theoretical and Experimental Demonstration of a Ru–H/D+ Exchange as the Key Step

(2014) M. Carmen Carrión et al.   ACS Catalysis

Proton or Metal? The H/D Exchange of Arenes in Acidic Solvents

(2014) Dominik Munz et al.   ACS Catalysis

Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

(2014) William J. Kerr et al.   ACS Catalysis

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

(2013) Lewis R. Vidler et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Plasmodium vivaxN-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

(2012) Victor Goncalves et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Iron-Catalyzed Direct Alkenylation of 2-Substituted Azaarenes withN-Sulfonyl Aldimines via C–H Bond Activation

(2011) Bo Qian et al.   ORGANIC LETTERS

Copper Catalyzed C−H Functionalization for Direct Mannich Reactions

(2011) Magnus Rueping et al.   ORGANIC LETTERS

Mild and Selective Deuteration and Isomerization of Alkenes by a Bifunctional Catalyst and Deuterium Oxide

(2009) Gülin Erdogan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal

(2008) Tomohiro Maegawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium‐Catalyzed H/D Exchange at Vinyl Groups without Olefin Isomerization

(2008) Jianrong Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective sp2and Benzylic sp3Palladium-Catalyzed Direct Arylation

(2008) Louis-Charles Campeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quinoline, quinazoline and acridonealkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS