Late-Stage β-C(sp3)–H Deuteration of Carboxylic Acids

The Emergence of Palladium‐Catalyzed C(sp3)‐H Functionalization of Free Carboxylic Acids

(2021) Animesh Das et al.   Chemistry-An Asian Journal

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C–H/C–H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F

(2021) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization

(2021) Qi-Kai Kang et al.   SYNLETT

Intramolecular Oxidative Coupling between Unactivated Aliphatic C–H and Aryl C–H Bonds

(2021) Yang Liao et al.   ORGANIC LETTERS

Recent Advances in External-Directing-Group-Free C–H Functionalization of Carboxylic Acids without Decarboxylation

(2021) Jayabrata Das et al.   ACS Catalysis

Catalytic Behavior of Mono-N -Protected Amino-Acid Ligands in Ligand-Accelerated C−H Activation by Palladium(II)

(2020) Chase A. Salazar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distal γ‐C(sp3)−H Olefination of Ketone Derivatives and Free Carboxylic Acids

(2020) Han Seul Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand‐Enabled γ‐C(sp 3 )−H Olefination of Free Carboxylic Acids

(2020) Kiron Kumar Ghosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiple Site Hydrogen Isotope Labelling of Pharmaceuticals

(2020) Marion Daniel-Bertrand et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct β‐ and γ‐C(sp 3 )−H Alkynylation of Free Carboxylic Acids

(2020) Francesca Ghiringhelli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

H–D Exchange Deuteration of Arenes at Room Temperature

(2019) Yoshinari Sawama et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Rapid Assessment of the Reaction-Condition-Based Sensitivity of Chemical Transformations

(2019) Lena Pitzer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides

(2019) Mégane Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand-Enabled Pd(II)-Catalyzed Iterative γ-C(sp3)−H Arylation of Free Aliphatic Acid

(2019) Pravas Dolui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highlights of aliphatic C (sp3 )-H Hydrogen Isotope Exchange Reactions

(2019) Mégane Valero et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Mechanism of the Palladium-Catalyzed C(sp3)–H Arylation of Aliphatic Amines: Unraveling the Crucial Role of Silver(I) Additives

(2019) Wenhui Feng et al.   ACS Catalysis

Discovery of Unforeseen Energy-Transfer-Based Transformations Using a Combined Screening Approach

(2019) Felix Strieth-Kalthoff et al.   Chem

Direct β-C(sp3)–H Acetoxylation of Aliphatic Carboxylic Acids

(2019) Kiron K. Ghosh et al.   ORGANIC LETTERS

A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII

(2019) Alyssa L. Garreau et al.   ORGANIC LETTERS

Direct C(sp3)–H Activation of Carboxylic Acids

(2019) Alexander Uttry et al.   SYNTHESIS-STUTTGART

Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation

(2019) Valentin Müller et al.   ChemCatChem

Lactonization as a general route to β-C(sp3)–H functionalization

(2019) Zhe Zhuang et al.   NATURE

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids

(2018) Donghong Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Multiple roles of silver salts in palladium-catalyzed C–H activations

(2018) Katherine L. Bay et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Free Carboxylic Acids

(2018) Peng-Xiang Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

(2018) J. Luke Koniarczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled β-C(sp3)–H Olefination of Free Carboxylic Acids

(2018) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Direct Pd-Catalyzed β-C(sp3)–H Activation of Carboxylic Acids

(2018) Manuel van Gemmeren et al.   SYNLETT

PdII -Catalyzed Enantioselective C(sp3 )−H Activation/Cross-Coupling Reactions of Free Carboxylic Acids

(2018) Liang Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Scale-Up of Stereoretentive α-Deuteration of Amines

(2017) Alessia Michelotti et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids

(2017) Yan Zhu et al.   Nature Communications

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

(2016) Tsuyoshi Yamada et al.   ADVANCED SYNTHESIS & CATALYSIS

Accelerated Discovery in Photocatalysis using a Mechanism-Based Screening Method

(2016) Matthew N. Hopkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Synthesis and selective2H-,13C-, and15N-labeling of the Tau protein binder THK-523

(2016) Karoline T. Neumann et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Vibrational Mode Assignment of α-Pinene by Isotope Editing: One Down, Seventy-One To Go

(2016) Mary Alice Upshur et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

C–H and O2 Activation at a Pt(II) Center Enabled by a Novel Sulfonated CNN Pincer Ligand

(2016) David Watts et al.   ORGANOMETALLICS

Role of Silver Salts in Palladium-Catalyzed Arene and Heteroarene C–H Functionalization Reactions

(2016) Monica D. Lotz et al.   ORGANOMETALLICS

The mechanism of palladium(II)-mediated C–H cleavage with mono-N-protected amino acid (MPAA) ligands: origins of rate acceleration

(2016) Keary M. Engle   PURE AND APPLIED CHEMISTRY

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic considerations on catalytic H/D exchange mediated by organometallic transition metal complexes

(2015) Andrea Di Giuseppe et al.   COMPTES RENDUS CHIMIE

Pd(II)-Catalyzed C–H Functionalizations Directed by Distal Weakly Coordinating Functional Groups

(2015) Gang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

H–D exchange in deuterated trifluoroacetic acid via ligand-directed NHC–palladium catalysis: a powerful method for deuteration of aromatic ketones, amides, and amino acids

(2015) Richard Giles et al.   TETRAHEDRON LETTERS

Highly Selective Continuous-Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives

(2015) Chi-Ting Hsieh et al.   ChemPlusChem

Regioselective ruthenium catalysed H–D exchange using D2O as the deuterium source

(2014) Lorenzo Piola et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights from quantitative metaproteomics and protein-stable isotope probing into microbial ecology

(2013) Martin von Bergen et al.   ISME Journal

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone

(2012) Henry H Ong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tritium: a coming of age for drug discovery and development ADME studies

(2012) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-13C,U-2H]Lactate

(2012) Brett W. C. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic Palladium-Catalyzed C(sp3)H Activation/C(sp3)O Bond Formation: A Direct, Step-Economical Route to Benzolactones

(2011) Petr Novák et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium substitutions in the L-DOPA molecule improve its anti-akinetic potency without increasing dyskinesias

(2010) Torun Malmlöf et al.   EXPERIMENTAL NEUROLOGY

The use of metal-catalysed hydrogen isotope exchange in the contract supply of tritiated compounds

(2010) Michael R. Chappelle et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Carboxylic Acids as Substrates in Homogeneous Catalysis

(2008) Lukas J. Gooßen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies

(2008) Abdul E. Mutlib   CHEMICAL RESEARCH IN TOXICOLOGY

Syntheses of (R,S)-naproxen and its 6-O-desmethylated metabolite labelled with2H

(2008) E. Fontana et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS