Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

New and Potent Quinuclidine-Based Antimicrobial Agents

(2019) Andreja Radman Kastelic et al.   MOLECULES

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives

(2018) Małgorzata Pająk et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Controllable deuteration of halogenated compounds by photocatalytic D2O splitting

(2018) Cuibo Liu et al.   Nature Communications

Deoxygenative Deuteration of Carboxylic Acids with D2 O

(2018) Muliang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent preparative applications of redox enzymes

(2018) Christopher K Prier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

(2017) Guangyue Li et al.   Chemical Science

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Enantiospecific CH Activation Using Ruthenium Nanocatalysts

(2015) Céline Taglang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling

(2015) Holly A. Reeve et al.   ChemCatChem

Relief from racemization

(2015) Stephen Davey   Nature Chemistry

Selectivity control in Pt-catalyzed cinnamaldehyde hydrogenation

(2015) Lee J. Durndell et al.   Scientific Reports

Structural basis for high substrate-binding affinity and enantioselectivity of 3-quinuclidinone reductase AtQR

(2014) Feng Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of an R -Selective Amine Oxidase with Broad Substrate Specificity and High Enantioselectivity

(2014) Rachel S. Heath et al.   ChemCatChem

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An Improved Process for the Preparation of Highly Pure Solifenacin Succinate via Resolution through Diastereomeric Crystallisation

(2014) Ganala Naga Trinadhachari et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Selective Catalytic Deuterium Labeling of Alcohols during a Transfer Hydrogenation Process of Ketones Using D2O as the Only Deuterium Source. Theoretical and Experimental Demonstration of a Ru–H/D+ Exchange as the Key Step

(2014) M. Carmen Carrión et al.   ACS Catalysis

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Expression, purification, crystallization and X-ray analysis of 3-quinuclidinone reductase fromAgrobacterium tumefaciens

(2012) Feng Hou et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A modular system for regeneration of NADcofactors using graphite particles modified with hydrogenase and diaphorase moieties

(2011) Holly A. Reeve et al.   CHEMICAL COMMUNICATIONS

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions

(2010) Göran N. Nilsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

HowEscherichia coliIs Equipped to Oxidize Hydrogen under Different Redox Conditions

(2009) Michael J. Lukey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad-14C,4-2H] NADPH and (4R)-[Ad-3H,4-2H] NADPH

(2009) Atsushi Yahashiri et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS