Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow

Difluorodiazoethane (CF2HCHN2): a new reagent for the introduction of the difluoromethyl group

(2019) Pavel Mykhailiuk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Facile synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles by the cyclization of gem-difluoroalkenes with acyl hydrazides

(2019) Xuxue Zhang et al.   Asian Journal of Organic Chemistry

Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

(2019) Jakapun Soponpong et al.   TETRAHEDRON LETTERS

Regio- and Enantioselective C–H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis

(2019) Wu-Bin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photocatalyzed Cyanodifluoromethylation of Alkenes

(2019) Min Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modular Continuous Flow Synthesis of Imatinib and Analogues

(2019) Wai Chung Fu et al.   ORGANIC LETTERS

Utilizing o-Quinone Methide Chemistry: Synthesis of d9-Ivacaftor

(2019) Adam R. Looker et al.   JOURNAL OF ORGANIC CHEMISTRY

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

(2018) Manuel Köckinger et al.   GREEN CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

(2018) Chang Xu et al.   Nature Communications

Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source

(2018) Manuel Köckinger et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes

(2017) Socrates B. Munoz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis, properties and application of electronically-tuned tetraarylarsonium salts as phase transfer catalysts (PTC) for the synthesis of gem -difluorocyclopropanes

(2017) Krzysztof Grudzień et al.   JOURNAL OF FLUORINE CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

CF2H, a Hydrogen Bond Donor

(2017) Chanan D. Sessler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

(2017) Hyowon Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

The Direct C–H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands

(2017) Ryu Sakamoto et al.   ORGANIC LETTERS

Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps

(2017) Munia F. Sowaileh et al.   TETRAHEDRON LETTERS

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Continuous-flow difluoromethylation with chlorodifluoromethane under biphasic conditions

(2017) Bernhard Gutmann et al.   Journal of Flow Chemistry

Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow

(2017) Biagia Musio et al.   ACS Sustainable Chemistry & Engineering

Metal-Catalyzed Direct Difluoromethylation Reactions

(2017) Jian Rong et al.   Asian Journal of Organic Chemistry

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

(2016) Ermal Ismalaj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuteration enhances catalyst lifetime in palladium-catalysed alcohol oxidation

(2016) Nicola Armenise et al.   CHEMICAL COMMUNICATIONS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

The Mechanism of Phosphonium Ylide Alcoholysis and Hydrolysis: Concerted Addition of the O−H Bond Across the P=C Bond

(2016) Peter A. Byrne et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions

(2016) Sankarganesh Krishnamoorthy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease

(2016) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

(2016) Hyowon Seo et al.   Nature Chemistry

Direct Nucleophilic Difluoromethylation of Carbonyl Compounds

(2016) Zuyong Deng et al.   ORGANIC LETTERS

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

First ever observation of the intermediate of phosphonium salt and ylide hydrolysis: P-hydroxytetraorganophosphorane

(2015) Peter A. Byrne et al.   CHEMICAL COMMUNICATIONS

Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols

(2015) Yusuke Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine in Drug Design: A Case Study with Fluoroanisoles

(2015) Li Xing et al.   ChemMedChem

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Well-Defined, Shelf-Stable (NHC)Ag(CF2H) Complexes for Difluoromethylation

(2015) Yang Gu et al.   ORGANOMETALLICS

A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

(2014) David R. Snead et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxygenativegem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl)trimethylsilane and triphenylphosphine

(2014) Fei Wang et al.   Beilstein Journal of Organic Chemistry

gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction

(2014) Bing Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Decarboxylative Julia-Kocienskigem-Difluoro-Olefination of 2-Pyridinyl Sulfonyldifluoroacetate

(2014) Xiao-Ping Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion

(2014) Vitalij V. Levin et al.   ORGANIC LETTERS

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Conversion between Difluorocarbene and Difluoromethylene Ylide

(2013) Jian Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Investigations on the Operation of Stereochemical Drift in the Wittig Reaction by NMR and Variable-Temperature NMR Spectroscopy of Oxaphosphetane Intermediates and Their Quench Products

(2013) Peter A. Byrne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The use of methyl 2,2-difluoro-2-(fluorosulfonyl)acetate as the difluorocarbene source to generate an in situ source of difluoromethylene triphenylphosphonium ylide

(2013) Charles S. Thomoson et al.   JOURNAL OF FLUORINE CHEMISTRY

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

(2013) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

(2013) David R. Snead et al.   Chemical Science

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unequivocal Experimental Evidence for a Unified Lithium Salt-Free Wittig Reaction Mechanism for All Phosphonium Ylide Types: Reactions with β-Heteroatom-Substituted Aldehydes Are Consistently Selective for cis-Oxaphosphetane-Derived Products

(2012) Peter A. Byrne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous-Flow Processes

(2011) Toma N. Glasnov et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

(2011) Rainer E. Martin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

On the Elucidation of the Mechanism ofVincaAlkaloid Fluorination in Superacidic Medium

(2011) Emerson Giovanelli et al.   ORGANIC LETTERS

Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature

(2011) Yanchuan Zhao et al.   ORGANIC LETTERS

Green and Sustainable Chemical Synthesis Using Flow Microreactors

(2010) Jun-ichi Yoshida et al.   ChemSusChem

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core: Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure

(2010) Angela D. Kerekes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl- and 2,2-Difluorovinyl Tosylates via the Suzuki−Miyaura Cross Coupling

(2008) Thomas M. Gøgsig et al.   JOURNAL OF ORGANIC CHEMISTRY

Investigations into the effectiveness of deuterium as a “protecting group” for C–H bonds in radical reactions involving hydrogen atom transfer

(2008) Mark E. Wood et al.   ORGANIC & BIOMOLECULAR CHEMISTRY