Deoxygenative Deuteration of Carboxylic Acids with D2 O

Exploration of C–H Transformations of Aldehyde Hydrazones: Radical Strategies and Beyond

(2018) Pan Xu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water-Gas Shift Reaction

(2018) Malek Y. S. Ibrahim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Photoredox Catalysis and Organocatalysis for Inverse Hydroboration of Imines

(2018) Nengneng Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

(2018) Wentao Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective α-Monomethylation by an Amine-Borane/N,N-Dimethylformamide System as the Methyl Source

(2018) Hui-Min Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distal radical migration strategy: an emerging synthetic means

(2018) Weipeng Li et al.   CHEMICAL SOCIETY REVIEWS

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

(2018) J. Luke Koniarczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controllable deuteration of halogenated compounds by photocatalytic D2O splitting

(2018) Cuibo Liu et al.   Nature Communications

Selective Hydroarylation of 1,3-Diynes Using a Dimeric Manganese Catalyst: Modular Synthesis of Z -Enynes

(2018) Zhongfei Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intermolecular Radical Mediated Anti-Markovnikov Alkene Hydroamination Using N-Hydroxyphthalimide

(2018) Samuel W. Lardy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

General and Practical Potassium Methoxide/Disilane-Mediated Dehalogenative Deuteration of (Hetero)Arylhalides

(2018) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A general deoxygenation approach for synthesis of ketones from aromatic carboxylic acids and alkenes

(2018) Muliang Zhang et al.   Nature Communications

Generation of Phosphoranyl Radicals via Photoredox Catalysis Enables Voltage–Independent Activation of Strong C–O Bonds

(2018) Erin E. Stache et al.   ACS Catalysis

Direct Aldehyde C–H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis

(2017) Xiaheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Deuteration with D2O: Catalysis and Mechanistic Insights

(2017) Valentin Soulard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Catalytic Deuteration of Aldehydes with D2O

(2017) Stephen Newman et al.   SYNLETT

Chemoselective Reduction of Tertiary Amides under Thermal Control: Formation of either Aldehydes or Amines

(2016) Fredrik Tinnis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

(2016) Haining Wang et al.   Nature Chemistry

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Advances in Photocatalysis: A Microreview of Visible Light Mediated Ruthenium and Iridium Catalyzed Organic Transformations

(2016) Kip Teegardin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A general photoinduced electron transfer-directed chemoselective perfluoroalkylation of N,N-dialkylhydrazones

(2016) Jin Xie et al.   Organic Chemistry Frontiers

Divergent CH Insertion-Cyclization Cascades ofN-Allyl Ynamides

(2015) Holly V. Adcock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl Radicals from Aromatic Carboxylic Acids by Means of Visible-Light Photoredox Catalysis

(2015) Giulia Bergonzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox-Catalyzed Reductive Coupling of Aldehydes, Ketones, and Imines with Visible Light

(2015) Masaki Nakajima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Induced Decarboxylative Functionalization of Carboxylic Acids and Their Derivatives

(2015) Jun Xuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Experimental and Theoretical Mechanistic Investigation of the Iridium-Catalyzed Dehydrogenative Decarbonylation of Primary Alcohols

(2015) Esben P. K. Olsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Mediated Decarboxylation/Oxidative Amidation of α-Keto Acids with Amines under Mild Reaction Conditions Using O2

(2013) Jie Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents

(2013) Yaoqiu Zhu et al.   ACS Medicinal Chemistry Letters

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-Catalyzed Decarboxylative Alkynylation of Aliphatic Carboxylic Acids in Aqueous Solution

(2012) Xuesong Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydroacylation of α,β-unsaturated esters via aerobic C–H activation

(2010) Vijay Chudasama et al.   Nature Chemistry