Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation

Catalytic α-Selective Deuteration of Styrene Derivatives

(2019) Thomas R. Puleo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomass-Derived Solvents for Sustainable Transition Metal-Catalyzed C‒H Activation

(2019) Gandeepan Parthasarathy et al.   ACS Sustainable Chemistry & Engineering

para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis

(2019) Kananat Naksomboon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ni(I)–X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals

(2019) Cayetana Zarate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange

(2019) Alberto Palazzolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Micellar Catalysis for Ruthenium(II)-Catalyzed C−H Arylation: Weak-Coordination-Enabled C−H Activation in H2O

(2019) Santhivardhana Reddy Yetra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals

(2019) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides

(2019) Mégane Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oligothiophene Synthesis by a General C–H Activation Mechanism: Electrophilic Concerted Metalation–Deprotonation (eCMD)

(2019) Long Wang et al.   ACS Catalysis

A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII

(2019) Alyssa L. Garreau et al.   ORGANIC LETTERS

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrooxidative Ruthenium-Catalyzed C−H/O−H Annulation by Weak O -Coordination

(2018) Youai Qiu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(ii) oxidase catalysis for C–H alkenylations in biomass-derived γ-valerolactone

(2018) Alexander Bechtoldt et al.   GREEN CHEMISTRY

Sequential meta-/ortho-C–H Functionalizations by One-Pot Ruthenium(II/III) Catalysis

(2018) Korkit Korvorapun et al.   ACS Catalysis

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals

(2018) Haifeng Yang et al.   ACS Catalysis

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange

(2018) William J. Kerr et al.   ACS Catalysis

Synthesis of Iron Hydride Complexes Relevant to Hydrogen Isotope Exchange in Pharmaceuticals

(2017) Renyuan Pony Yu et al.   ORGANOMETALLICS

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Air-Stable α-Diimine Nickel Precatalysts for the Hydrogenation of Hindered, Unactivated Alkenes

(2017) Nadia G. Léonard et al.   ACS Catalysis

Recent Developments in Ruthenium-Catalyzed C–H Arylation: Array of Mechanistic Manifolds

(2017) Pradeep Nareddy et al.   ACS Catalysis

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Manganese(I)-Catalyzed Substitutive C−H Allylation

(2016) Weiping Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Stereoretentive H/D Exchange via an Electroactivated Heterogeneous Catalyst at sp3C-H Sites Bearing Amines or Alcohols

(2016) Souful Bhatia et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Selective α-Deuteration of Amines and Amino Acids Using D2O

(2016) Basujit Chatterjee et al.   ORGANIC LETTERS

Ruthenium Oxidase Catalysis for Site-Selective C-H Alkenylations with Ambient O2 as the Sole Oxidant

(2015) Alexander Bechtoldt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed CH Activation/Alkyne Annulation by Weak Coordination with O2as the Sole Oxidant

(2015) Svenja Warratz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ruthenium-Catalyzed Deuteration of Alcohols with Deuterium Oxide

(2015) Wei Bai et al.   ORGANOMETALLICS

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Ruthenium(II)-Catalyzed Oxidative CH Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides

(2014) Wenbo Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium(I)-Catalyzed Regioselective CH Activation and Hydrogen-Isotope Exchange of Non-aromatic Unsaturated Functionality

(2014) William J. Kerr et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Regioselective ruthenium catalysed H–D exchange using D2O as the deuterium source

(2014) Lorenzo Piola et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

(2014) Brigitte Buscher et al.   Bioanalysis

Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

(2014) William J. Kerr et al.   ACS Catalysis

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Olefins Using Chiral Crabtree-type Catalysts: Scope and Limitations

(2013) J. Johan Verendel et al.   CHEMICAL REVIEWS

A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development

(2013) Joel A. Krauser   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of pharmaceutical salts and cocrystals to address the issue of poor solubility

(2012) David P. Elder et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tritium: a coming of age for drug discovery and development ADME studies

(2012) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Regioselective Deuteration of Alcohols at the β-Carbon Position with Deuterium Oxide

(2011) Sunny Kai San Tse et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium-Catalyzed Oxidative C–H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones

(2011) Lutz Ackermann et al.   ORGANIC LETTERS

Platinum and Palladium Complexes Containing Cationic Ligands as Catalysts for Arene H/D Exchange and Oxidation

(2010) Marion H. Emmert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Rhodium- and ruthenium-catalysed hydrogen isotope exchange

(2010) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Tritium labelling of pharmaceuticals by metal-catalysed exchange methods

(2010) D. Hesk et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions

(2010) Göran N. Nilsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

(2008) Jack A. Brown et al.   CHEMICAL COMMUNICATIONS