Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water

Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O

(2020) Nengbo Zhu et al.   ORGANIC LETTERS

Rapid, Heterogeneous Biocatalytic Hydrogenation and Deuteration in a Continuous Flow Reactor

(2020) Lisa Alice Thompson et al.   ChemCatChem

Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

(2020) J. S. Rowbotham et al.   Nature Communications

Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters

(2020) Stephanie W. Chun et al.   ACS Catalysis

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

A primer of deuterium in drug design

(2019) Sarah Cargnin et al.   Future Medicinal Chemistry

Reductive Deuteration of Nitriles Using D2O as a Deuterium Source

(2019) Yuxuan Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2

(2019) Simon J. Freakley et al.   Nature Communications

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis

(2019) Huihui Geng et al.   Nature Catalysis

Improved strategies for electrochemical 1,4-NAD(P)H 2 regeneration: A new era of bioreactors for industrial biocatalysis

(2018) Clifford S. Morrison et al.   BIOTECHNOLOGY ADVANCES

Controllable deuteration of halogenated compounds by photocatalytic D2O splitting

(2018) Cuibo Liu et al.   Nature Communications

Activity and Stability of Pt/C and Pt-Cu/C Electrocatalysts

(2018) V. E. Guterman et al.   Electrocatalysis

Nonequivalence of Second Sphere “Noncatalytic” Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes

(2018) Andreea I. Iorgu et al.   ACS Catalysis

Chemical Basis for Deuterium Labeling of Fat and NADPH

(2017) Zhaoyue Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Chemoenzymatic Synthesis of Ubiquitous Biological Redox Cofactors

(2017) Amnon Kohen et al.   SYNLETT

Transfer of photosynthetic NADP+/NADPH recycling activity to a porous metal oxide for highly specific, electrochemically-driven organic synthesis

(2017) Bhavin Siritanaratkul et al.   Chemical Science

Electronic metal-support interaction enhanced oxygen reduction activity and stability of boron carbide supported platinum

(2017) Colleen Jackson et al.   Nature Communications

Cofactor NAD(P)H Regeneration Inspired by Heterogeneous Pathways

(2017) Xiaodong Wang et al.   Chem

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

(2016) Jonathan Latham et al.   Nature Communications

Photocatalytic Regeneration of Nicotinamide Cofactors by Quantum Dot–Enzyme Biohybrid Complexes

(2016) Katherine A. Brown et al.   ACS Catalysis

Heterogeneous Catalysis Mediated Cofactor NADH Regeneration for Enzymatic Reduction

(2016) Xiaodong Wang et al.   ACS Catalysis

Relief from racemization

(2015) Stephen Davey   Nature Chemistry

Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H

(2015) Tommaso Quinto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs

(2015) Vincent Jacques et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining the ‘two worlds’ of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

(2014) Harald Gröger et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Comparison of carbon materials as electrodes for enzyme electrocatalysis: hydrogenase as a case study

(2014) Jonathan Quinson et al.   FARADAY DISCUSSIONS

Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

(2013) Carl A. Denard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of NADH Binding, Hydride Transfer, and NAD+ Dissociation during NADH Oxidation by Mitochondrial Complex I Using Modified Nicotinamide Nucleotides

(2013) James A. Birrell et al.   BIOCHEMISTRY

Methods for the regeneration of nicotinamide coenzymes

(2013) Hong Wu et al.   GREEN CHEMISTRY

Photocatalytic Reduction of Artificial and Natural Nucleotide Co-factors with a Chlorophyll-Like Tin-Dihydroporphyrin Sensitizer

(2013) Kerstin T. Oppelt et al.   INORGANIC CHEMISTRY

Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

(2013) Carl A. Denard et al.   ACS Catalysis

Direct electrochemical regeneration of the enzymatic cofactor 1,4-NADH employing nano-patterned glassy carbon/Pt and glassy carbon/Ni electrodes

(2012) Irshad Ali et al.   CHEMICAL ENGINEERING JOURNAL

Catalytic Properties of the Isolated Diaphorase Fragment of the NAD+-Reducing [NiFe]-Hydrogenase from Ralstonia eutropha

(2011) Lars Lauterbach et al.   PLoS One

Biocatalytic Redox Reactions for Organic Synthesis: Nonconventional Regeneration Methods

(2010) Frank Hollmann et al.   ChemCatChem

Structural and electrocatalytic features of Pt/C catalysts fabricated in supercritical carbon dioxide

(2010) Ernest E. Said-Galiyev et al.   JOURNAL OF SOLID STATE ELECTROCHEMISTRY

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY