Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)–H bonds directed by a sulfur atom

(2018) Longhui Gao et al.   CHEMICAL COMMUNICATIONS

Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

(2018) Mégane Valero et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange

(2018) William J. Kerr et al.   ACS Catalysis

Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts

(2017) Annina Burhop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Burgess iridium(I)-catalyst for selective hydrogen isotope exchange

(2017) Annina Burhop et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

Deuterium medicinal chemistry comes of age

(2016) Roger D Tung   Future Medicinal Chemistry

A convenient route to a norbornadiene adduct of iridium with chelating phosphines, [Ir(R 2 PCH 2 CH 2 PR 2 )(NBD)][ BAr 4 F ] and a comparison of reactivity with H 2 in solution and the solid–state

(2016) F. Mark Chadwick et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Mechanism Studies of Ir-Catalyzed Asymmetric Hydrogenation of Unsaturated Carboxylic Acids

(2016) Mao-Lin Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium Hydride Complexes with Cyclohexyl-Based Pincer Ligands: Fluxionality and Deuterium Exchange

(2016) Alexey V. Polukeev et al.   ORGANOMETALLICS

Enantiospecific CH Activation Using Ruthenium Nanocatalysts

(2015) Céline Taglang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kinetic Isotope Effects (KIE) and Density Functional Theory (DFT): A Match Made in Heaven?

(2015) Peter Fristrup et al.   SYNLETT

Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

(2015) Jens Atzrodt et al.   TETRAHEDRON

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed H/D Exchange: Ligand Complexes with Improved Efficiency and Scope

(2014) Michael Parmentier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

(2014) A. R. Cochrane et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

(2014) Brigitte Buscher et al.   Bioanalysis

Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

(2014) William J. Kerr et al.   ACS Catalysis

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development

(2013) Joel A. Krauser   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Use of the Imine–Enamine Equilibrium in Cooperative Ligand Design

(2013) Truman C. Wambach et al.   ORGANOMETALLICS

Characterization and Reactivity Studies of Dinuclear Iridium Hydride Complexes Prepared from Iridium Catalysts with N,P and C,N Ligands under Hydrogenation Conditions

(2013) Stefan Gruber et al.   ORGANOMETALLICS

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution

(2012) Eric G. Solon   CHEMICAL RESEARCH IN TOXICOLOGY

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tritium: a coming of age for drug discovery and development ADME studies

(2012) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

(2012) Daniel Harder et al.   Nature Protocols

Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System

(2012) Hironao Sajiki et al.   SYNLETT

Synthesis of new serine-based phosphinooxazoline ligands and iridium complexes for asymmetric hydrogenations

(2011) Axel Franzke et al.   TETRAHEDRON

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange

(2010) Rhys Salter   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions

(2010) Göran N. Nilsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Structure and Reactivity of New Iridium Complexes with Bis(Oxazoline)-Phosphonito Ligands

(2009) Riccardo Peloso et al.   INORGANIC CHEMISTRY

Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

(2008) Jack A. Brown et al.   CHEMICAL COMMUNICATIONS

Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies

(2008) Abdul E. Mutlib   CHEMICAL RESEARCH IN TOXICOLOGY