B(C 6 F 5 ) 3 ‐Catalyzed α ‐Deuteration of Bioactive Carbonyl Compounds with D 2 O

Applications of deuterium in medicinal chemistry

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Enantioselective Conia-Ene-Type Cyclizations of Alkynyl Ketones through Cooperative Action of B(C6F5)3, N-Alkylamine and a Zn-Based Catalyst

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Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C–H Bonds of Drug Molecules

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Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

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C−H Functionalisation for Hydrogen Isotope Exchange

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Chiral Supramolecular U-Shaped Catalysts Induce the Multiselective Diels–Alder Reaction of Propargyl Aldehyde

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Catalytic Access to Bridged Sila-N-heterocycles from Piperidines via Cascade sp3 and sp2 C–Si Bond Formation

(2018) Jianbo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late-stage chemoselective functional-group manipulation of bioactive natural products with super-electrophilic silylium ions

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B(C6F5)3-Catalyzed Regioselective Deuteration of Electron-Rich Aromatic and Heteroaromatic Compounds

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A catalytic fluoride-rebound mechanism for C(sp3)-CF3bond formation

(2017) Mark D. Levin et al.   SCIENCE

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

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Frustrated Lewis Acid/Brønsted Base Catalysts for Direct Enantioselective α-Amination of Carbonyl Compounds

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Iron-catalysed tritiation of pharmaceuticals

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The broadening reach of frustrated Lewis pair chemistry

(2016) D. W. Stephan   SCIENCE

ProPhenol-Catalyzed Asymmetric Additions by Spontaneously Assembled Dinuclear Main Group Metal Complexes

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Frustrated Lewis Pair Chemistry: Development and Perspectives

(2015) Douglas W. Stephan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A unified survey of Si–H and H–H bond activation catalysed by electron-deficient boranes

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Frustrated Lewis Pairs

(2015) Douglas W. Stephan   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A simple method forα-position deuterated carbonyl compounds with pyrrolidine as catalyst

(2014) Miao Zhan et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-free asymmetric hydrogenation and hydrosilylation catalyzed by frustrated Lewis pairs

(2014) Xiangqing Feng et al.   TETRAHEDRON LETTERS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric H–D exchange reactions of fluorinated aromatic ketones

(2012) Yujun Zhao et al.   CHEMICAL COMMUNICATIONS

Tritium: a coming of age for drug discovery and development ADME studies

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Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

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A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

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In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

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Bifunctional Asymmetric Catalysis: Cooperative Lewis Acid/Base Systems

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