Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

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Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

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Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)–H bonds directed by a sulfur atom

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Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

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Hydrogen-Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts

(2017) Annina Burhop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Burgess iridium(I)-catalyst for selective hydrogen isotope exchange

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Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds

(2017) W. Neil Palmer et al.   ACS Catalysis

Antibody drug conjugates

(2016) Ray Bakhtiar   BIOTECHNOLOGY LETTERS

Antibody-drug conjugates—an emerging class of cancer treatment

(2016) Nikolaos Diamantis et al.   BRITISH JOURNAL OF CANCER

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C–H activation of unprotected tetrazoles

(2016) William J. Kerr et al.   CHEMICAL COMMUNICATIONS

New developments for antibody-drug conjugate-based therapeutic approaches

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Deuterium medicinal chemistry comes of age

(2016) Roger D Tung   Future Medicinal Chemistry

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiospecific CH Activation Using Ruthenium Nanocatalysts

(2015) Céline Taglang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics

(2015) Eunhee G. Kim et al.   Biomolecules & Therapeutics

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

(2015) Amrita V. Kamath et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Ruthenium-Catalyzed Deuteration of Alcohols with Deuterium Oxide

(2015) Wei Bai et al.   ORGANOMETALLICS

Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

(2015) Jens Atzrodt et al.   TETRAHEDRON

The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange

(2014) Jack A. Brown et al.   ADVANCED SYNTHESIS & CATALYSIS

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

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Iridium-Catalyzed H/D Exchange: Ligand Complexes with Improved Efficiency and Scope

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Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models

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Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

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Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

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Iridium-Catalyzed C–H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

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A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development

(2013) Joel A. Krauser   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Trends in Translational Medicine and Drug Targeting and Delivery: New Insights on an Old Concept—Targeted Drug Delivery with Antibody–Drug Conjugates for Cancers

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Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution

(2012) Eric G. Solon   CHEMICAL RESEARCH IN TOXICOLOGY

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

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Tritium: a coming of age for drug discovery and development ADME studies

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Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

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Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

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Ligand binding assays at equilibrium: validation and interpretation

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Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange

(2010) Rhys Salter   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions

(2010) Göran N. Nilsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

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Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

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Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies

(2008) Abdul E. Mutlib   CHEMICAL RESEARCH IN TOXICOLOGY