O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

Cross-Reactivity of Pantoprazole with Three Commercial Cannabinoids Immunoassays in Urine

(2017) Isabel Gomila et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Modeling and Simulation of Pivotal Clinical Trials Using Linked Models for Multiple Endpoints in Chronic Obstructive Pulmonary Disease With Roflumilast

(2017) Axel Facius et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Strategic incorporation of fluorine into taxoid anticancer agents for medicinal chemistry and chemical biology studies

(2017) Iwao Ojima   JOURNAL OF FLUORINE CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development

(2017) Scott L. Harbeson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects

(2017) Nimesh Khadka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review

(2017) Bao-Cheng Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

(2017) Jinyan Yang et al.   ORGANIC LETTERS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Deutetrabenazine for Treatment of Chorea in Huntington Disease

(2016) Michael D. Geschwind et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group

(2016) Kostiantyn Levchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Fluorination methods in drug discovery

(2016) Damian E. Yerien et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

(2014) William R. Dolbier et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

(2014) D. A. E. Cross et al.   Cancer Discovery

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

(2013) Patrick S. Fier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Difluoromethylation and trifluoromethylation reagents derived from tetrafluoroethane β-sultone: Synthesis, reactivity and applications

(2013) Cheng-Pan Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

(2013) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

(2013) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

A deuterated analog of dasatinib disrupts cell cycle progression and displays anti-non-small cell lung cancer activityin vitroandin vivo

(2012) Chunhua Ling et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source

(2011) Fei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

(2010) Fei Wang et al.   CHEMICAL COMMUNICATIONS

Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor

(2009) Yossi Zafrani et al.   TETRAHEDRON