A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols

Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

(2014) Ge Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Capricious Selectivity in Electrophilic Deuteration of Methylenedioxy Substituted Aromatic Compounds

(2014) Monika Pohjoispää et al.   JOURNAL OF ORGANIC CHEMISTRY

A convenient method for the Ru(0)-catalyzed regioselective deuteration of N-alkyl-substituted anilines

(2014) Miao Zhan et al.   TETRAHEDRON LETTERS

Platinum on Carbon-Catalyzed H-D Exchange Reaction of Aromatic Nuclei due to Isopropyl Alcohol-Mediated Self- Activation of Platinum Metal in Deuterium Oxide

(2013) Yoshinari Sawama et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588

(2013) Paul W. Manley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Effect of Solvent and Ancillary Ligands on the Catalytic H/D Exchange Reactivity of Cp*IrIII(L) Complexes

(2013) Matthew C. Lehman et al.   ACS Catalysis

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A deuterated analog of dasatinib disrupts cell cycle progression and displays anti-non-small cell lung cancer activityin vitroandin vivo

(2012) Chunhua Ling et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis of Deuterated 1,2,3-Triazoles

(2012) Hari K. Akula et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid, Microwave-Assisted Perdeuteration of Polycyclic Aromatic Hydrocarbons

(2012) Allison K. Greene et al.   JOURNAL OF ORGANIC CHEMISTRY

Decarboxylative C–H Arylation of Benzoic Acids under Radical Conditions

(2012) Sangwon Seo et al.   ORGANIC LETTERS

Catalytic Arene H/D Exchange with Novel Rhodium and Iridium Complexes

(2012) Jennifer L. Rhinehart et al.   ORGANOMETALLICS

Efficient H-D Exchange Reactions Using Heterogeneous Platinum-Group Metal on Carbon-H2-D2O System

(2012) Hironao Sajiki et al.   SYNLETT

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of Oxidized Welwitindolinones and (−)-N-Methylwelwitindolinone C Isonitrile

(2011) Kyle W. Quasdorf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Platinum and Palladium Complexes Containing Cationic Ligands as Catalysts for Arene H/D Exchange and Oxidation

(2010) Marion H. Emmert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective

(2010) Jens Atzrodt et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Desvenlafaxine: A new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder

(2009) Richard Perry et al.   CLINICAL THERAPEUTICS

Big interest in heavy drugs

(2009) Katharine Sanderson   NATURE

Efficient and Selective Pt/C-Catalyzed H–D Exchange Reaction of Aromatic Rings

(2008) Nobuhiro Ito et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

A Simple, Cost-Effective Method for the Regioselective Deuteration of Anilines

(2008) Andrew Martins et al.   ORGANIC LETTERS