Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?

Polyphenols from Food and Natural Products: Neuroprotection and Safety

(2020) Rui F. M. Silva et al.   Antioxidants

Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity

(2020) Justine R. Horne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DNA damage and DNA protection from digested raw and griddled green pepper (poly)phenols in human colorectal adenocarcinoma cells (HT-29)

(2020) Estíbaliz Huarte et al.   EUROPEAN JOURNAL OF NUTRITION

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

(2020) Francesca Oppedisano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of lignans in oilseed mix on gut microbiome composition and enterolignan production in younger healthy and premenopausal women: an in vitro pilot study

(2020) Giulia Corona et al.   Microbial Cell Factories

Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

(2020) Yusuke Matsuno et al.   Scientific Reports

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice

(2020) Bo Xia et al.   PLOS BIOLOGY

Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model

(2020) Noelia Sánchez-Marzo et al.   Antioxidants

MAY PHYTOTHERAPY WITH POLYPHENOLS SERVE AS A POWERFUL APPROACH FOR THE PREVENTION AND THERAPY TOOL OF NOVEL CORONAVIRUS DISEASE 2019 (COVID-19)?

(2020) Emile Levy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterization of bioactive cranberry fractions by mass spectrometry

(2020) Marie-Claude Denis et al.   Canadian Journal of Chemistry

Enhancement of polyphenolic metabolism as an adaptive response of lettuce (Lactuca sativa) roots to aluminum stress

(2020) Yao Chen et al.   ENVIRONMENTAL POLLUTION

The role of anthocyanins as antidiabetic agents: from molecular mechanisms to in vivo and human studies

(2020) Francisco Les et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet‐induced Insulin Resistance in Mice

(2020) Jieping Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

(2020) Janice S. Mani et al.   VIRUS RESEARCH

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

(2020) Viviana Sandoval et al.   Nutrients

Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers

(2020) Isabel Anna Maria Groh et al.   BMC Chemistry

Healthy dietary patterns to reduce obesity-related metabolic disease

(2020) Camilla Diotallevi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Carob fruit extract-enriched meat improves pancreatic beta-cell dysfunction, hepatic insulin signaling and lipogenesis in late-stage type 2 diabetes mellitus model

(2020) Adrián Macho-González et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

(2020) María Jesús Pérez de Vega et al.   Antioxidants

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

(2019) Kyuichi Kawabata et al.   MOLECULES

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity

(2019) Margherita Springer et al.   Nutrients

Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology

(2019) Ibrahim Abdelgawad et al.   Nutrients

The Mediterranean Diet and Cardiovascular Health

(2019) Miguel A. Martínez-González et al.   CIRCULATION RESEARCH

Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases

(2019) Rosa Vona et al.   Oxidative Medicine and Cellular Longevity

Polyphenol-Enriched Plum Extract Enhances Myotubule Formation and Anabolism while Attenuating Colon Cancer-induced Cellular Damage in C2C12 Cells

(2019) Faten A. Alsolmei et al.   Nutrients

The Gastrointestinal Tract as Prime Site for Cardiometabolic Protection by Dietary Polyphenols

(2019) Jose A Villa-Rodriguez et al.   Advances in Nutrition

Identification of DNA-Methylated CpG Islands Associated With Gene Silencing in the Adult Body Tissues of the Ogye Chicken Using RNA-Seq and Reduced Representation Bisulfite Sequencing

(2019) Won-Jun Lim et al.   Frontiers in Genetics

Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats

(2019) Immacolata Cristina Nettore et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polyphenols: Immunomodulatory and Therapeutic Implication in Colorectal Cancer

(2019) Anna Maria Mileo et al.   Frontiers in Immunology

Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

(2019) Xiangbing Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia‐TLR4‐NFκB‐Mediated Inflammation

(2019) Geoffrey Y. Sasaki et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition

(2019) Egeria Scoditti et al.   Nutrients

Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency

(2019) Amit Kumar Singh et al.   Nutrients

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

(2019) Sara Carpi et al.   Nutrients

Antioxidant and Anti-Inflammatory Properties of a Thuja occidentalis Mother Tincture for the Treatment of Ulcerative Colitis

(2019) Miruna Silvia Stan et al.   Antioxidants

In Vitro Digestion of Apple Tissue Using a Dynamic Stomach Model: Grinding and Crushing Effects on Polyphenol Bioaccessibility

(2019) Dongjie Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Red Raspberry Polyphenols Attenuate High‐Fat Diet–Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications

(2019) Rong Fan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans

(2018) Fabio Castello et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Immunomodulation by food: impact on gut immunity and immune cell function

(2018) Satoshi Hachimura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome

(2018) María V. Selma et al.   CLINICAL NUTRITION

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

(2018) Gary Williamson et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Dietary Protein and Gut Microbiome Composition and Function

(2018) Jianfei Zhao et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial

(2018) Konstantinos Kantartzis et al.   DIABETES OBESITY & METABOLISM

Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe-derived ring cleavage metabolites

(2018) Xinchi Feng et al.   DRUG METABOLISM REVIEWS

Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species

(2018) Wataru Komatsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Colonic metabolites from flavanols stimulate nitric oxide production in human endothelial cells and protect against oxidative stress-induced toxicity and endothelial dysfunction

(2018) David Álvarez-Cilleros et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant and antidiabetic activity of blackberry after gastrointestinal digestion and human gut microbiota fermentation

(2018) Vemana Gowd et al.   FOOD CHEMISTRY

Effects of Equol Supplement on Bone and Cardiovascular Parameters in Middle-Aged Japanese Women: A Prospective Observational Study

(2018) Remi Yoshikata et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation

(2018) Rosemari Otton et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids

(2018) Schohraya Spahis et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond

(2018) Zhiyong Cheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis

(2018) Pantea Rahmani Yeganeh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

(2018) Gina Borges et al.   MOLECULAR ASPECTS OF MEDICINE

A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial

(2018) Evelien Van Rymenant et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Diet, Microbiota, and Metabolic Health: Trade-Off Between Saccharolytic and Proteolytic Fermentation

(2018) Katri Korpela   Annual Review of Food Science and Technology

Intestinal Absorption and Antioxidant Activity of Grape Pomace Polyphenols

(2018) Veronica Chedea et al.   Nutrients

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States

(2018) Charlotte Atkinson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice

(2018) Fernando F Anhê et al.   GUT

Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?

(2018) Isabel Gutiérrez-Díaz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population

(2018) Thomas Reinehr et al.   Current Diabetes Reports

Antiobesity Effect of Prebiotic Polyphenol-Rich Grape Seed Flour Supplemented with Probiotic Kefir-Derived Lactic Acid Bacteria

(2018) Yun-Ju Cho et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Lignans: Definition, Description and Research Trends in Databases Development

(2018) Alessandra Durazzo et al.   MOLECULES

A Review of Lignan Metabolism, Milk Enterolactone Concentration, and Antioxidant Status of Dairy Cows Fed Flaxseed

(2018) André Brito et al.   MOLECULES

Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages

(2018) Luis Vitetta et al.   Frontiers in Immunology

Childhood Obesity and the Metabolic Syndrome

(2018) Edward Nehus et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Stability of resveratrol esters with caprylic acid during simulated in vitro gastrointestinal digestion

(2018) Xiao-Pei Hu et al.   FOOD CHEMISTRY

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

Comparison of phytochemical profiles, antioxidant and cellular antioxidant activities of different varieties of blueberry ( Vaccinium spp.)

(2017) Huailing Wang et al.   FOOD CHEMISTRY

5-(3′,4′-Dihydroxyphenyl-γ-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion

(2017) Charles C. Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW 264.7 Macrophages and Dendritic Cells

(2017) Giang Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function

(2017) Laura Mele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling

(2017) J. Domínguez Avila et al.   MOLECULES

Role of phenolic compounds during antioxidative responses of winter triticale to aphid and beetle attack

(2017) Paweł Czerniewicz et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

(2017) E. Van Rymenant et al.   Food & Function

Association of Polyphenol Biomarkers with Cardiovascular Disease and Mortality Risk: A Systematic Review and Meta-Analysis of Observational Studies

(2017) et al.   Nutrients

Effect of Green and Brown Propolis Extracts on the Expression Levels of microRNAs, mRNAs and Proteins, Related to Oxidative Stress and Inflammation

(2017) Vincenzo Zaccaria et al.   Nutrients

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

(2017) Elise Saunier et al.   Scientific Reports

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms

(2016) Hui-fang Su et al.   ACTA PHARMACOLOGICA SINICA

Ameliorative effect of grape seed extract on metabolic disorders caused by high fat diet induced obesity in rats by reversing the increase in hepatic miR-33a and miR-122

(2016) E. Mohamed Hoda et al.   African Journal of Pharmacy and Pharmacology

Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

(2016) Simona D'Amore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects

(2016) Antonella Smeriglio et al.   BRITISH JOURNAL OF PHARMACOLOGY

The potential health effects of dietary phytoestrogens

(2016) Ivonne M C M Rietjens et al.   BRITISH JOURNAL OF PHARMACOLOGY

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

(2016) M.-C. Denis et al.   CLINICAL SCIENCE

3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides

(2016) Yue Tang et al.   FOOD RESEARCH INTERNATIONAL

Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids inPseudomonas aeruginosaand Increases Biofilm Susceptibility to Antibiotic Treatment

(2016) Marcel Stenvang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes

(2016) Zafar Rasheed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Esterification of Quercetin Increases Its Transport Across Human Caco-2 Cells

(2016) Jiang-ning Hu et al.   JOURNAL OF FOOD SCIENCE

The gut microbiota and metabolic disease: current understanding and future perspectives

(2016) T. Arora et al.   JOURNAL OF INTERNAL MEDICINE

Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation

(2016) Inhae Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study

(2016) Ana Rodriguez-Mateos et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

(2016) Eva Brglez Mojzer et al.   MOLECULES

Involvement of miR-Let7A in inflammatory response and cell survival/apoptosis regulated by resveratrol in THP-1 macrophage

(2016) Juhyun Song et al.   Nutrition Research and Practice

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

(2016) Weiyou Wang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target

(2016) Sivapragasam Gothai et al.   Nutrients

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

(2016) Javier I. Ottaviani et al.   Scientific Reports

Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats

(2015) Apurva A. Javkhedkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol and diabetes: from animal to human studies

(2015) Tomasz Szkudelski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

(2015) Roberto Sansone et al.   BRITISH JOURNAL OF NUTRITION

A perspective on vegetarian dietary patterns and risk of metabolic syndrome

(2015) Joan Sabaté et al.   BRITISH JOURNAL OF NUTRITION

Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans

(2015) Shama V. Joseph et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Characterization of polyphenols and evaluation of antioxidant capacity in grape pomace of the cv. Malbec

(2015) Andrea Antoniolli et al.   FOOD CHEMISTRY

Effects of Metabolites Produced from (−)-Epigallocatechin Gallate by Rat Intestinal Bacteria on Angiotensin I-Converting Enzyme Activity and Blood Pressure in Spontaneously Hypertensive Rats

(2015) Akiko Takagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database

(2015) Joseph A. Rothwell et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potential protective properties of flax lignan secoisolariciresinol diglucoside

(2015) Muhammad Imran et al.   Nutrition Journal

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

(2015) Swapna Upadhyay et al.   Oxidative Medicine and Cellular Longevity

The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin – A biochemical study in rats subjected to experimental hyperlipidemia and obesity

(2015) Padmanabhan Monika et al.   PHYTOMEDICINE

Hydrolysis of the Rutinose-Conjugates Flavonoids Rutin and Hesperidin by the Gut Microbiota and Bifidobacteria

(2015) Alberto Amaretti et al.   Nutrients

Tea polyphenols as an antivirulence compound Disrupt Quorum-Sensing Regulated Pathogenicity of Pseudomonas aeruginosa

(2015) Hongping Yin et al.   Scientific Reports

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Comprehensive Foodomics Study on the Mechanisms Operating at Various Molecular Levels in Cancer Cells in Response to Individual Rosemary Polyphenols

(2014) Alberto Valdés et al.   ANALYTICAL CHEMISTRY

3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling

(2014) Kang-Yi Su et al.   BMC Complementary and Alternative Medicine

Metabolism of Flavonoids in Human: A Comprehensive Review

(2014) Zhongjian Chen et al.   CURRENT DRUG METABOLISM

Gut Microbiota Metabolites of Dietary Lignans and Risk of Type 2 Diabetes: A Prospective Investigation in Two Cohorts of U.S. Women

(2014) Qi Sun et al.   DIABETES CARE

Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein

(2014) C L Frankenfeld et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Human intestinal microbial metabolism of naringin

(2014) Wei Zou et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

(2014) Elisa Fernández-Millán et al.   FOOD AND CHEMICAL TOXICOLOGY

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Enhanced uptake and transport of (+)-catechin and (-)-epigallocatechin gallate in niosomal formulation by human intestinal Caco-2 cells

(2014) Qinxin Song et al.   International Journal of Nanomedicine

Modulation of Strawberry/Cranberry Phenolic Compounds Glucuronidation by Co-Supplementation with Onion: Characterization of Phenolic Metabolites in Rat Plasma Using an Optimized μSPE–UHPLC-MS/MS Method

(2014) Stéphanie Dudonné et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

(2014) Francisco A. Tomás-Barberán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemical Profile and Antioxidative and Antimicrobial Activity of Juices and Extracts of 4 Black Currants Varieties (Ribes nigrumL.)

(2014) Bojana Miladinović et al.   JOURNAL OF FOOD SCIENCE

Urinary Isoflavone Concentrations Are Inversely Associated with Cardiometabolic Risk Markers in Pregnant U.S. Women

(2014) Ling Shi et al.   JOURNAL OF NUTRITION

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

(2014) Miriam Méndez-del Villar et al.   Metabolic Syndrome and Related Disorders

Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

(2014) Sevtap Han et al.   MOLECULAR BIOLOGY REPORTS

Cardiovascular Risks in Relation to Daidzein Metabolizing Phenotypes among Chinese Postmenopausal Women

(2014) Zhao-min Liu et al.   PLoS One

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

(2013) Junhai Ou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota

(2013) Lisa M Bode et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

(2013) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Influence of Glucuronidation and Reduction Modifications of Resveratrol on its Biological Activities

(2013) Dong-Liang Lu et al.   CHEMBIOCHEM

The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES

(2013) Tristan Struja et al.   EUROPEAN JOURNAL OF NUTRITION

Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats

(2013) Goiuri Alberdi et al.   FOOD CHEMISTRY

Berry (Poly)phenols and Cardiovascular Health

(2013) Ana Rodriguez-Mateos et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Factors Influence Production of the Soy Isoflavone Metabolite S-(-)Equol in Healthy Adults

(2013) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

(2013) Pon Velayutham Anandh Babu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats

(2013) Uma Rani P. et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Childhood Obesity and Cardiovascular Dysfunction

(2013) Anita T. Cote et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The antioxidant activity of daidzein metabolites, O-desmethylangolensin and equol, in HepG2 cells

(2013) EUN JEONG CHOI et al.   Molecular Medicine Reports

Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns

(2013) Noemi Boqué et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study

(2013) Yuko Tousen et al.   Nutrition Journal

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

(2013) João Tomé-Carneiro et al.   PHARMACOLOGICAL RESEARCH

Soy isoflavones and their relationship with microflora: beneficial effects on human health in equol producers

(2013) Juan Manuel Sánchez-Calvo et al.   PHYTOCHEMISTRY REVIEWS

Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

(2013) Marie Claude Denis et al.   PLoS One

Cocoa Consumption Alters the Global DNA Methylation of Peripheral Leukocytes in Humans with Cardiovascular Disease Risk Factors: A Randomized Controlled Trial

(2013) Anna Crescenti et al.   PLoS One

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidative Properties of Functional Polyphenols and Their Metabolites Assessed by an ORAC Assay

(2012) Hidekazu ISHIMOTO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Animal models for determining amino acid digestibility in humans – a review

(2012) Amelie Deglaire et al.   BRITISH JOURNAL OF NUTRITION

Effects of naturalS-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status

(2012) Takeshi Usui et al.   CLINICAL ENDOCRINOLOGY

Effect of cocoa and green tea on biomarkers of glucose regulation, oxidative stress, inflammation and hemostasis in obese adults at risk for insulin resistance

(2012) K S Stote et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

(2012) Sunil K. Panchal et al.   EUROPEAN JOURNAL OF NUTRITION

Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol)

(2012) Klaus Uhlenhut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of polymer molecular weight on relative oral bioavailability of curcumin

(2012) Tung-Hu Tsai et al.   International Journal of Nanomedicine

Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice

(2012) Vishnupriya Gourineni et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Urinary Enterolignan Concentrations Are Positively Associated with Serum HDL Cholesterol and Negatively Associated with Serum Triglycerides in U.S. Adults

(2012) José L. Peñalvo et al.   JOURNAL OF NUTRITION

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

(2012) Juan A. Giménez-Bastida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Evidence that cranberry juice may improve augmentation index in overweight men

(2012) Guillaume Ruel et al.   NUTRITION RESEARCH

Effect of quercetin on inflammatory gene expression in mice liver in vivo – role of redox factor 1, miRNA-122 and miRNA-125b

(2012) Christine Boesch-Saadatmandi et al.   PHARMACOLOGICAL RESEARCH

Dietary intake of 337 polyphenols in French adults

(2011) Jara Pérez-Jiménez et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Potential Mechanisms by Which Polyphenol-Rich Grapes Prevent Obesity-Mediated Inflammation and Metabolic Diseases

(2011) Chia-Chi Chuang et al.   Annual Review of Nutrition

Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes

(2011) Yasuko Makino-Wakagi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

(2011) Hidekazu Ishimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunochemical Detection of Food-Derived Polyphenols in the Aorta: Macrophages as a Major Target Underlying the Anti-Atherosclerotic Activity of Polyphenols

(2011) Yoshichika KAWAI   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Faecal microbiota composition in vegetarians: comparison with omnivores in a cohort of young women in southern India

(2011) Jayakanthan Kabeerdoss et al.   BRITISH JOURNAL OF NUTRITION

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Interactions between Polyphenols and Macromolecules: Quantification Methods and Mechanisms

(2011) C. Le Bourvellec et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Influence of Cultivar, Harvest Time, Storage Conditions, and Peeling on the Antioxidant Capacity and Phenolic and Ascorbic Acid Contents of Apples and Pears

(2011) Claire Kevers et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyphenolics from Açaí (Euterpe oleracea Mart.) and Red Muscadine Grape (Vitis rotundifolia) Protect Human Umbilical Vascular Endothelial Cells (HUVEC) from Glucose- and Lipopolysaccharide (LPS)-Induced Inflammation and Target MicroRNA-126

(2011) Giuliana D. Noratto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolites and tissue distribution of resveratrol in the pig

(2011) María Azorín-Ortuño et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites

(2011) Elena Verzelloni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Epigenetic priming of the metabolic syndrome

(2011) Kimberley D Bruce et al.   TOXICOLOGY MECHANISMS AND METHODS

Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review

(2010) Jara Pérez-Jiménez et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study

(2010) Xenofon Tzounis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Daidzein-metabolising phenotypes in relation to serum lipids and uric acid in adults in Guangzhou, China

(2010) Kaiping Guo et al.   BRITISH JOURNAL OF NUTRITION

Genoprotective effects of green tea ( Camellia sinensis) in human subjects: results of a controlled supplementation trial

(2010) K. C. Han et al.   BRITISH JOURNAL OF NUTRITION

Colonic metabolites of berry polyphenols: the missing link to biological activity?

(2010) Gary Williamson et al.   BRITISH JOURNAL OF NUTRITION

NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts

(2010) Antonio González-Sarrías et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

(2010) Esmerina Tili et al.   CARCINOGENESIS

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Intestinal transit and systemic metabolism of apple polyphenols

(2010) Kathrin Kahle et al.   EUROPEAN JOURNAL OF NUTRITION

Bioavailability of the Polyphenols: Status and Controversies

(2010) Massimo D’Archivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy†

(2010) Rocío González-Barrio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enterodiol and Enterolactone Modulate the Immune Response by Acting on Nuclear Factor-κB (NF-κB) Signaling

(2010) Emanuela Corsini et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Genoprotective Effects of the Green Tea-Derived Polyphenol/Epicatechin Gallate in C6 Astroglial Cells

(2010) Renata T. Abib et al.   JOURNAL OF MEDICINAL FOOD

Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155☆

(2010) Christine Boesch-Saadatmandi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rapid analysis of procyanidins and anthocyanins in plasma by microelution SPE and ultra-HPLC

(2010) Maria-Pilar Martí et al.   JOURNAL OF SEPARATION SCIENCE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites

(2010) Maria Monagas et al.   Food & Function

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells

(2009) María Monagas et al.   BRITISH JOURNAL OF NUTRITION

Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models

(2009) Aida Serra et al.   BRITISH JOURNAL OF NUTRITION

Health effects with consumption of the flax lignan secoisolariciresinol diglucoside

(2009) Jennifer L. Adolphe et al.   BRITISH JOURNAL OF NUTRITION

Bioactive Food Components, Inflammatory Targets, and Cancer Prevention

(2009) Y. S. Kim et al.   Cancer Prevention Research

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

(2009) Dobroslawa Bialonska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Fat Content on the Digestibility and Bioaccessibility of Cocoa Polyphenol by an in Vitro Digestion Model

(2009) Nàdia Ortega et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Total Phenolic, Phenolic Acid, Anthocyanin, Flavan-3-ol, and Flavonol Profiles and Antioxidant Properties of Pinto and Black Beans (Phaseolus vulgaris L.) as Affected by Thermal Processing

(2009) Baojun Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Bioavailability of Apigenin-7-Glucoside Is Influenced by Human Intestinal Microbiota in Rats

(2009) Laura Hanske et al.   JOURNAL OF NUTRITION

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Ussing type chamber model to study the intestinal transport and modulation of specific tight-junction genes using a colonic cell line

(2009) Hannah Bergmann et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models

(2009) Mar Larrosa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary phenolics: chemistry, bioavailability and effects on health

(2009) Alan Crozier et al.   NATURAL PRODUCT REPORTS

Ellagic acid suppresses oxidised low-density lipoprotein-induced aortic smooth muscle cell proliferation: studies on the activation of extracellular signal-regulated kinase 1/2 and proliferating cell nuclear antigen expression

(2008) Weng-Cheng Chang et al.   BRITISH JOURNAL OF NUTRITION

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

Covalent interactions between amino acid side chains and oxidation products of caffeoylquinic acid (chlorogenic acid)

(2008) Stéphanie VE Prigent et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE