4.7 Article

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries

Journal

FOOD & FUNCTION
Volume 8, Issue 12, Pages 4331-4335

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7fo01273j

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Funding

  1. Agency for Innovation by Science and Technology in Flanders (IWT)
  2. European Union [312090]
  3. BBSRC [BBS/E/F/00044434, BBS/E/F/00042675] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [BBS/E/F/00042675, BBS/E/F/00044434] Funding Source: researchfish

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Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate - not their glucuronidated forms or ferulic acid - caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

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