Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells

(2017) Michinori Takashina et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) α1 in mice fed high-fat diet

(2017) Songbo Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Differential sensitivities of bladder cancer cell lines to resveratol are unrelated to its metabolic profile

(2017) Yang Yang et al.   Oncotarget

Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells

(2016) Naoki Mizutani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancer metabolism at a glance

(2016) Alexei Vazquez et al.   JOURNAL OF CELL SCIENCE

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

(2016) L. Zhang et al.   Science Translational Medicine

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis

(2016) Vanessa Graillot et al.   Frontiers in Cellular and Infection Microbiology

Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle

(2015) Thomas K. Sin et al.   ACTA DIABETOLOGICA

The molecular targets of resveratrol

(2015) Sameer S. Kulkarni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin

(2015) Justine Lanzini et al.   BIOCHIMIE

Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors

(2015) Andrei G. Vlassenko et al.   DISEASE MARKERS

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents

(2015) Elise Saunier et al.   INTERNATIONAL JOURNAL OF CANCER

Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

(2015) J. Gambini et al.   Oxidative Medicine and Cellular Longevity

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

(2015) Hong Cai et al.   Science Translational Medicine

Cardiac Energy Metabolism and Oxidative Stress Biomarkers in Diabetic Rat Treated with Resveratrol

(2014) Klinsmann Carolo dos Santos et al.   PLoS One

Resveratrol Enhances Palmitate-Induced ER Stress and Apoptosis in Cancer Cells

(2014) Cristina Rojas et al.   PLoS One

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

(2014) D J Colin et al.   Cell Death & Disease

Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

(2014) Yi Qiao et al.   Food & Function

Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells

(2013) Jun Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase

(2013) Ching-An Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase

(2013) Lilian S. Gomez et al.   BIOCHIMIE

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma

(2013) Qishan Tang et al.   CANCER LETTERS

AMPK: A Contextual Oncogene or Tumor Suppressor?

(2013) J. Liang et al.   CANCER RESEARCH

Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans

(2013) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

(2013) So Hee Jin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin

(2012) Mohd Askandar Iqbal et al.   PLoS One

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

Functional Parsing of Driver Mutations in the Colorectal Cancer Genome Reveals Numerous Suppressors of Anchorage-Independent Growth

(2011) U. Eskiocak et al.   CANCER RESEARCH

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Inhibitory Effects of Resveratrol and Pterostilbene on Human Colon Cancer Cells: A Side-by-Side Comparison

(2011) Wasamon Nutakul et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells

(2011) Otito F. Iwuchukwu et al.   LIFE SCIENCES

Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach

(2011) Jairam Vanamala et al.   Proteome Science

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

(2010) Puspa R. Pandey et al.   BREAST CANCER RESEARCH AND TREATMENT

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

(2010) Jean-Marc Blouin et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro

(2009) Andres I. Roig et al.   GASTROENTEROLOGY

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

(2008) Gabriela Suchankova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Potential of resveratrol in anticancer and anti-inflammatory therapy

(2008) Chibuike C Udenigwe et al.   NUTRITION REVIEWS

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark