Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition

Downregulation of Pro-Inflammatory and Pro-Angiogenic Pathways in Prostate Cancer Cells by a Polyphenol-Rich Extract from Olive Mill Wastewater

(2019) Denisa Baci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

(2019) Yong Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation and Immunity: From an Adipocyte's Perspective

(2019) Calvin C. Chan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Targeting endothelial-to-mesenchymal transition: the protective role of hydroxytyrosol sulfate metabolite

(2019) Erika Terzuoli et al.   EUROPEAN JOURNAL OF NUTRITION

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells

(2019) Rebecca M. Wadey et al.   ATHEROSCLEROSIS

Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D

(2018) Esma Karkeni et al.   Epigenetics

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells

(2018) Sara Carpi et al.   Marine Drugs

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

(2018) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization

(2018) Zulong Xie et al.   Journal of the American Heart Association

miRWalk: An online resource for prediction of microRNA binding sites

(2018) Carsten Sticht et al.   PLoS One

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Repression of adipose Vascular Endothelial Growth Factor reduces obesity through adipose browning

(2018) Yang Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis

(2018) Ping Tong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

(2017) Rosa Casas et al.   MEDIATORS OF INFLAMMATION

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

(2017) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

miRNA Signatures of Insulin Resistance in Obesity

(2017) Angela Jones et al.   Obesity

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death

(2017) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial

(2017) Carmela Colica et al.   Oxidative Medicine and Cellular Longevity

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

(2017) Julien Peyrol et al.   Nutrients

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes

(2017) Verena Zoller et al.   Scientific Reports

Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in ObesityHighlights

(2016) Laura J. Den Hartigh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

(2016) Simona D'Amore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial

(2016) Alexander Medina-Remón et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation

(2016) Bruno Stefanon et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Importance of adipocyte cyclooxygenase-2 and prostaglandin E2–prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance

(2016) Pei-Chi Chan et al.   FASEB JOURNAL

Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans

(2016) Stefania Rigacci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity-associated Inflammation Induces microRNA-155 Expression in Adipocytes and Adipose Tissue: Outcome on Adipocyte Function

(2016) Esma Karkeni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Extra virgin olive oil rich in polyphenols modulates VEGF-induced angiogenic responses by preventing NADPH oxidase activity and expression

(2016) Nadia Calabriso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

(2016) Joao Tomé-Carneiro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: The PREDIMED study

(2016) Antoni Sureda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats

(2016) Adriano Lama et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The modern interleukin-1 superfamily: Divergent roles in obesity

(2016) Man K.S. Lee et al.   SEMINARS IN IMMUNOLOGY

Anti-inflammatory role of microRNA let-7c in LPS treated alveolar macrophages by targeting STAT3

(2016) Ji-Hui Yu et al.   Asian Pacific Journal of Tropical Medicine

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

(2016) C. Santangelo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice

(2016) Jongkil Kim et al.   Molecular Therapy-Nucleic Acids

miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity

(2016) Andrew D. Gaudet et al.   Scientific Reports

Virgin olive oil: a key food for cardiovascular risk protection

(2015) María-Isabel Covas et al.   BRITISH JOURNAL OF NUTRITION

Virgin olive oil rich in phenolic compounds modulates the expression of atherosclerosis-related genes in vascular endothelium

(2015) Eliana R. Meza-Miranda et al.   EUROPEAN JOURNAL OF NUTRITION

A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women

(2015) C. E. Storniolo et al.   EUROPEAN JOURNAL OF NUTRITION

Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial

(2015) Rosa-M. Valls et al.   FOOD CHEMISTRY

Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3-L1 Preadipocyte Cell Line

(2015) Valeria Tutino et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic Syndrome

(2015) Jordi Salas-Salvadó et al.   JOURNAL OF NUTRITION

Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells

(2015) Úrsula Catalán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of Hydroxytyrosol-dependent Regulation of HO-1 Expression in Promoting Wound Healing of Vascular Endothelial CellsviaNrf2De NovoSynthesis and Stabilization

(2015) Houda Zrelli et al.   PHYTOTHERAPY RESEARCH

Additive Regulation of Adiponectin Expression by the Mediterranean Diet Olive Oil Components Oleic Acid and Hydroxytyrosol in Human Adipocytes

(2015) Egeria Scoditti et al.   PLoS One

Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation

(2014) Roberto Carnevale et al.   ATHEROSCLEROSIS

Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway

(2014) W Zhang et al.   CELL DEATH AND DIFFERENTIATION

Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis

(2014) Ying Shen et al.   Evidence-based Complementary and Alternative Medicine

Regulation of obesity and insulin resistance by nitric oxide

(2014) Brian E. Sansbury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: A nutrigenomic study

(2014) E. Giordano et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Hydroxytyrosol Prevents Increase of Osteoarthritis Markers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene α

(2014) Annalisa Facchini et al.   PLoS One

Vascular effects of the Mediterranean diet—Part II: Role of omega-3 fatty acids and olive oil polyphenols

(2014) Egeria Scoditti et al.   VASCULAR PHARMACOLOGY

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

(2014) María Tabernero et al.   Food & Function

Mediterranean Diet and Cardiovascular Health: Teachings of the PREDIMED Study

(2014) Emilio Ros et al.   Advances in Nutrition

The Multifaceted Functions of CXCL10 in Cardiovascular Disease

(2014) Pleunie van den Borne et al.   Biomed Research International

Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition

(2013) Egeria Scoditti et al.   ATHEROSCLEROSIS

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Hepatocyte growth factor and interferon-γ inducible protein-10 are related to visceral adiposity

(2013) Daniël R. Faber et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes

(2013) Patrizia Rosignoli et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity

(2013) S. Ahlin et al.   Obesity

Resveratrol Suppresses PAI-1 Gene Expression in a HumanIn VitroModel of Inflamed Adipose Tissue

(2013) Ivana Zagotta et al.   Oxidative Medicine and Cellular Longevity

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

Crosstalk between Immune Cells and Adipocytes Requires Both Paracrine Factors and Cell Contact to Modify Cytokine Secretion

(2013) Carolina Franco Nitta et al.   PLoS One

Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans

(2012) Olga Castañer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial Function in Young Women with Mild Hypertension

(2012) Rafael Moreno-Luna et al.   AMERICAN JOURNAL OF HYPERTENSION

Inflammation and metabolic dysfunction: links to cardiovascular diseases

(2012) Annika Taube et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer

(2012) Egeria Scoditti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells

(2012) Juan Li et al.   BMC MOLECULAR BIOLOGY

Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype

(2012) Brian E. Sansbury et al.   CIRCULATION RESEARCH

The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells

(2012) Petra S. Eisele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

(2012) Maliheh Nazari-Jahantigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

(2012) Julio Wainstein et al.   JOURNAL OF MEDICINAL FOOD

Modulation of miRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols

(2012) Dragan Milenkovic et al.   PLoS One

Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people

(2011) Antonio Camargo et al.   BRITISH JOURNAL OF NUTRITION

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

(2011) Matthias Van Hul et al.   ENDOCRINE JOURNAL

Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK–FOXO3a pathway

(2011) Houda Zrelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis

(2011) Maarten Hulsmans et al.   FASEB JOURNAL

ICAM-1: Getting a Grip on Leukocyte Adhesion

(2011) E. O. Long   JOURNAL OF IMMUNOLOGY

Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells

(2011) Riadh Drira et al.   LIFE SCIENCES

Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Production in Macrophages

(2011) Nathalie Richard et al.   PLANTA MEDICA

Vascular targeting of adipose tissue as an anti-obesity approach

(2011) Alexes C. Daquinag et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

eNOS plays a major role in adiponectin synthesis in adipocytes

(2010) Eun Hee Koh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Monocyte Chemoattractant Protein-1 Deficiency Protects Against Visceral Fat-Induced Atherosclerosis

(2010) Miina K. Öhman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil

(2010) Antonio Camargo et al.   BMC GENOMICS

Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway

(2010) Weili Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial

(2010) Valentini Konstantinidou et al.   FASEB JOURNAL

Adipose tissue macrophages: their role in adipose tissue remodeling

(2010) Takayoshi Suganami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats

(2010) Hemant Poudyal et al.   JOURNAL OF NUTRITION

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nitric oxide and AMPK cooperatively regulate PGC-1α in skeletal muscle cells

(2010) Vitor A. Lira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gelatinase B (MMP-9) deficiency does not affect murine adipose tissue development

(2010) Matthias Van Hul et al.   THROMBOSIS AND HAEMOSTASIS

Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

(2009) Vicenta Llorente-Cortés et al.   ATHEROSCLEROSIS

Suppressive Effects of Hydroxytyrosol on Oxidative Stress and Nuclear Factor-κB Activation in THP-1 Cells

(2009) Xiaomei Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

(2009) Z.-b. Deng et al.   DIABETES

miR-155: On the Crosstalk Between Inflammation and Cancer

(2009) Esmerina Tili et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

(2009) Jiejie Hao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MicroRNAlet-7Regulates 3T3-L1 Adipogenesis

(2009) Tingwan Sun et al.   MOLECULAR ENDOCRINOLOGY

Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells

(2009) Xiaomei Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

COX-2-mediated Inflammation in Fat Is Crucial for Obesity-linked Insulin Resistance and Fatty Liver

(2009) Po-Shiuan Hsieh et al.   Obesity

Time Course of Changes in the Expression of Insulin Sensitivity-Related Genes after an Acute Load of Virgin Olive Oil

(2009) Valentini Konstantinidou et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

A functional role of gelatinase A in the development of nutritionally induced obesity in mice

(2008) M. VAN HUL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS