Gut microbiota-mediated metabolism of green tea catechins and the biological consequences: An updated review

Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

(2023) Shuling Zhang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden

(2022) Lisa M Olsson et al.   Cell Host & Microbe

Epigallocatechin 3-gallate: From green tea to cancer therapeutics

(2022) Manzar Alam et al.   FOOD CHEMISTRY

A Screening of Native (Poly)phenols and Gut‐Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan‐3‐ol Metabolite

(2022) Josep Rubert et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Improving the stability and bioavailability of tea polyphenols by encapsulations: a review

(2022) Zhiya Yin et al.   Food Science and Human Wellness

Rethinking healthy eating in light of the gut microbiome

(2022) Anissa M. Armet et al.   Cell Host & Microbe

Cellular Antioxidant Effect of an Aronia Extract and Its Polyphenolic Fractions Enriched in Proanthocyanidins, Phenolic Acids, and Anthocyanins

(2022) Cécile Dufour et al.   Antioxidants

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

(2022) Dan-Dan Zhou et al.   Frontiers in Nutrition

Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3′,4′-Dihydroxy-Phenyl)-γ-Valerolactone in Regulating Nrf2-Mediated Gene Expression

(2022) Chen Liu et al.   Frontiers in Nutrition

A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

(2022) Diogo Carregosa et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Tea phenolics as prebiotics

(2022) Zhibin Liu et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Gut Microbial Metabolite Pyrogallol Is a More Potent Inducer of Nrf2-Associated Gene Expression Than Its Parent Compound Green Tea (-)-Epigallocatechin Gallate

(2022) Chen Liu et al.   Nutrients

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

(2021) Marjan Talebi et al.   PHYTOTHERAPY RESEARCH

Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression

(2021) Min Luo et al.   FOOD REVIEWS INTERNATIONAL

Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

(2021) Karla Fabiola Corral-Jara et al.   Frontiers in Neuroscience

Gut microbiota as a driver of the interindividual variability of cardiometabolic effects from tea polyphenols

(2021) Qiqiong Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Flavan‐3‐ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid‐beta (1‐42) Levels

(2021) Valentina Cecarini et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antiproliferative Effect of Colonic Fermented Phenolic Compounds from Jaboticaba (Myrciaria trunciflora) Fruit Peel in a 3D Cell Model of Colorectal Cancer

(2021) Paula Rossini Augusti et al.   MOLECULES

Green Tea and Its Relation to Human Gut Microbiome

(2021) Sergio Pérez-Burillo et al.   MOLECULES

Priority effects in microbiome assembly

(2021) Reena Debray et al.   NATURE REVIEWS MICROBIOLOGY

Comparative Microbial Conversion of Deoxynivalenol and Acetylated Deoxynivalenol in Different Parts of the Chicken Intestine as Detected In Vitro and Translated to the In Vivo Situation

(2021) Jing Jin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PBK Model‐Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity

(2021) Diana M. Mendez‐Catala et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

(2021) Qiqiong Li et al.   MOLECULES

Advances in physiological functions and mechanisms of (−)-epicatechin

(2020) Zhihao Qu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Beneficial Properties of Green Tea Catechins

(2020) Claudia Musial et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation

(2020) Qianrui Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease

(2020) Roberta Ruotolo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect

(2020) Jie Ouyang et al.   Oxidative Medicine and Cellular Longevity

C-ring cleavage metabolites of catechin and epicatechin enhanced antioxidant activities through intestinal microbiota

(2020) Wanbing Chen et al.   FOOD RESEARCH INTERNATIONAL

Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health

(2020) Marina Fassarella et al.   GUT

Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro

(2020) Zhibin Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbial Metabolism of Theaflavin-3,3′-digallate and Its Gut Microbiota Composition Modulatory Effects

(2020) Zhibin Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds

(2020) Chen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interindividual Differences in Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐ O ‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression

(2020) Chen Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A new genomic blueprint of the human gut microbiota

(2019) Alexandre Almeida et al.   NATURE

Effects and mechanisms of tea for the prevention and management of cancers: An updated review

(2019) Xiao-Yu Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Effects of Microbial Metabolites of (−)-Epigallocatechin Gallate on Glucose Uptake in L6 Skeletal Muscle Cell and Glucose Tolerance in ICR Mice

(2019) Akiko Takagaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Overall Dietary Quality Relates to Gut Microbiota Diversity and Abundance

(2019) Kirsi Laitinen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure–Activity Relationship) Models

(2019) Lynda Bouarab-Chibane et al.   Frontiers in Microbiology

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

(2019) Diogo Carregosa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation of 1-(3′,4′-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

(2019) Michał Gleńsk et al.   MOLECULES

Biological fates of tea polyphenols and their interactions with microbiota in the gastrointestinal tract: implications on health effects

(2019) Tingting Chen et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Interactions of tea catechins with intestinal microbiota and their implication for human health

(2019) Tongtong Guo et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Dietary polyphenols to combat the metabolic diseases via altering gut microbiota

(2019) Vemana Gowd et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models

(2019) Donato Angelino et al.   Nutrients

Gut microbiota as an “invisible organ” that modulates the function of drugs

(2019) Xiang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

(2019) Guo-Yi Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes

(2018) Pedro Mena et al.   EUROPEAN JOURNAL OF NUTRITION

Green and black tea phenolics - Bioavailability, transformation by colonic microbiota, and modulation of colonic microbiota

(2018) Zhibin Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High-Fat Diet Treated HFA Mice

(2018) Li Wang et al.   JOURNAL OF FOOD SCIENCE

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

(2018) Gina Borges et al.   MOLECULAR ASPECTS OF MEDICINE

Metagenomics Analysis of Gut Microbiota in a High Fat Diet-Induced Obesity Mouse Model Fed with (−)-Epigallocatechin 3-O -(3-O -Methyl) Gallate (EGCG3″Me)

(2018) Xin Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Role of Catechins in Cellular Responses to Oxidative Stress

(2018) Jurga Bernatoniene et al.   MOLECULES

Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics

(2018) C. Behr et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

(2018) Wanda C. Reygaert   Biomed Research International

The relationship between standard reduction potentials of catechins and biological activities involved in redox control

(2018) Monika Baranowska et al.   Redox Biology

Aronia (Aronia melanocarpa ) Polyphenols Modulate Microbial Community in Simulator of the Human Intestinal Microbial Ecosystem (SHIME® ) and Decrease Secretion of Pro-Inflammatory Markers in a Caco-2/endothelial Cell Co-Culture Model

(2018) Ting Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bioavailability of Tea Catechins and Its Improvement

(2018) Zhuo-Yu Cai et al.   MOLECULES

In Vitro Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota

(2018) Sophie Fehlbaum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation

(2018) Jonna E. B. Koper et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Activity of Urolithin A and M4 Valerolactone, Colonic Microbiota Metabolites of Polyphenols, in a Prostate Cancer In Vitro Model

(2018) Iwona Stanisławska et al.   PLANTA MEDICA

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

5-(3′,4′-Dihydroxyphenyl-γ-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion

(2017) Charles C. Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells

(2017) Keiko Unno et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function

(2017) Laura Mele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The green tea modulates large intestinal microbiome and exo/endogenous metabolome altered through chronic UVB-exposure

(2017) Eun Sung Jung et al.   PLoS One

5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells

(2017) Pedro Mena et al.   Journal of Functional Foods

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Altitudinal effects on the quality of green tea in east China: a climate change perspective

(2016) Wen-Yan Han et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activities

(2016) Yoon Hee Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in Hairless Mouse Skin

(2016) Jong-Eun Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer Preventive Activities of Tea Catechins

(2016) Chung Yang et al.   MOLECULES

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

(2016) Javier I. Ottaviani et al.   Scientific Reports

Bioconversion of (−)-Epicatechin, (+)-Epicatechin, (−)-Catechin, and (+)-Catechin by (−)-Epigallocatechin-Metabolizing Bacteria

(2015) Akiko Takagaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Biotransformation of (−)-Epigallocatechin and (−)-Gallocatechin by Intestinal Bacteria Involved in Isoflavone Metabolism

(2015) Akiko Takagaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fecal microbiota analysis: an overview of sample collection methods and sequencing strategies

(2015) Vincent Thomas et al.   Future Microbiology

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

(2015) Jing Cheng et al.   ISME Journal

Effects of Metabolites Produced from (−)-Epigallocatechin Gallate by Rat Intestinal Bacteria on Angiotensin I-Converting Enzyme Activity and Blood Pressure in Spontaneously Hypertensive Rats

(2015) Akiko Takagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI

(2015) Elvira Barroso et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

A new phenolic derivative with soluble epoxide hydrolase and nuclear factor-kappaB inhibitory activity from the aqueous extract ofAcacia catechu

(2015) Ya Nan Sun et al.   NATURAL PRODUCT RESEARCH

Isolation and characterization of rat intestinal bacteria involved in biotransformation of (−)-epigallocatechin

(2014) Akiko Takagaki et al.   ARCHIVES OF MICROBIOLOGY

Rapid and Sustained Systemic Circulation of Conjugated Gut Microbial Catabolites after Single-Dose Black Tea Extract Consumption

(2014) John van Duynhoven et al.   JOURNAL OF PROTEOME RESEARCH

Gallic acid: Molecular rival of cancer

(2013) Sharad Verma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Simultaneous detection of green tea catechins and gallic acid in human serum after ingestion of green tea tablets using ion-pair high-performance liquid chromatography with electrochemical detection

(2013) Keiko Narumi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The Approach to Sample Acquisition and Its Impact on the Derived Human Fecal Microbiome and VOC Metabolome

(2013) Robin D. Couch et al.   PLoS One

Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. CAT-1 Capable of Cleaving the C-Ring of (+)-Catechin and (^|^#8722;)-Epicatechin, Followed by p-Dehydroxylation of the B-Ring

(2012) Jong-Sik Jin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol)

(2012) Klaus Uhlenhut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Capability of Lactobacillus plantarum IFPL935 To Catabolize Flavan-3-ol Compounds and Complex Phenolic Extracts

(2012) Fernando Sánchez-Patán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of green tea consumption on human fecal microbiota with special reference toBifidobacteriumspecies

(2012) Jong-Sik Jin et al.   MICROBIOLOGY AND IMMUNOLOGY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Microarray Analysis and Barcoded Pyrosequencing Provide Consistent Microbial Profiles Depending on the Source of Human Intestinal Samples

(2011) Bartholomeus van den Bogert et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antioxidative Activity of Microbial Metabolites of (−)-Epigallocatechin Gallate Produced in Rat Intestines

(2011) Akiko TAKAGAKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Green tea catechins during food processing and storage: A review on stability and detection

(2011) Victoria K. Ananingsih et al.   FOOD RESEARCH INTERNATIONAL

Isolation of catechin-converting human intestinal bacteria

(2011) M. Kutschera et al.   JOURNAL OF APPLIED MICROBIOLOGY

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Metabolism of (−)-Epigallocatechin Gallate by Rat Intestinal Flora

(2010) Akiko Takagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vitro Bioconversion of Polyphenols from Black Tea and Red Wine/Grape Juice by Human Intestinal Microbiota Displays Strong Interindividual Variability

(2010) Gabriele Gross et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

White and Green Teas (Camellia sinensis var. sinensis): Variation in Phenolic, Methylxanthine, and Antioxidant Profiles

(2010) Uchenna J. Unachukwu et al.   JOURNAL OF FOOD SCIENCE

Bioavailability and catabolism of green tea flavan-3-ols in humans

(2010) Daniele Del Rio et al.   NUTRITION

Human milk glycobiome and its impact on the infant gastrointestinal microbiota

(2010) A. M. Zivkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites

(2010) Maria Monagas et al.   Food & Function

Beneficial effects of green tea: A literature review

(2010) Sabu M Chacko et al.   Chinese Medicine

Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression

(2008) Małgorzata Muzolf-Panek et al.   CHEMICAL RESEARCH IN TOXICOLOGY