Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression

The In Vivo Antioxidant and Hepatoprotective Actions of Selected Chinese Teas

(2020) Shi-Yu Cao et al.   Foods

EGCG ameliorates neuronal and behavioral defects by remodeling gut microbiota and TotM expression in Drosophila models of Parkinson’s disease

(2020) Yi Xu et al.   FASEB JOURNAL

Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

(2020) Ewa Baranowska-Wójcik et al.   Nutrients

Comparative Kinetics of Acetyl- and Butyryl-Cholinesterase Inhibition by Green Tea Catechins|Relevance to the Symptomatic Treatment of Alzheimer’s Disease

(2020) Edward J. Okello et al.   Nutrients

Protective effect of epigallocatechin‐3‐gallate against neuroinflammation and anxiety‐like behavior in a rat model of myocardial infarction

(2020) Jinpeng Wang et al.   Brain and Behavior

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

(2020) Xiao Meng et al.   Foods

Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice

(2020) Jian Bao et al.   Current Medical Science

Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action

(2019) Jun Tao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation

(2019) Yasuhisa Ano et al.   MOLECULES

Effects and mechanisms of tea for the prevention and management of cancers: An updated review

(2019) Xiao-Yu Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Epigallocatechin Gallate Protects against TNFα- or H2O2- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model

(2019) Qi Xu et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Ripened Pu-erh tea extract protects mice from obesity by modulating gut microbiota composition

(2019) Xiaojie Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tea polyphenols as multi-target therapeutics for Alzheimer’s disease: An in silico study

(2019) Muhammed Khairujjaman Mazumder et al.   MEDICAL HYPOTHESES

Neuroprotective attributes of L-theanine, a bioactive amino acid of tea, and its potential role in Parkinson's disease therapeutics

(2019) Satarupa Deb et al.   NEUROCHEMISTRY INTERNATIONAL

Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition

(2019) Antonio Inserra et al.   Scientific Reports

MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model

(2019) Qiang Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

(2019) Dylan O’Neill Rothenberg et al.   Nutrients

Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice

(2019) Juewon Kim et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Interactions of tea catechins with intestinal microbiota and their implication for human health

(2019) Tongtong Guo et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Epigallocatechin‐3‐Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF‐κB Pathway

(2019) Xin Zhong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Association between tea consumption and depressive symptom among Chinese older adults

(2019) Ke Shen et al.   BMC Geriatrics

The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)

(2019) Zhou et al.   Cells

Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products

(2019) Li et al.   Foods

Effects of Tannase and Ultrasound Treatment on the Bioactive Compounds and Antioxidant Activity of Green Tea Extract

(2019) Xiao-Yu Xu et al.   Antioxidants

Effects of Food Processing on In Vivo Antioxidant and Hepatoprotective Properties of Green Tea Extracts

(2019) Xiao-Yu Xu et al.   Antioxidants

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

(2019) Guo-Yi Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice

(2019) Miren Ettcheto et al.   MOLECULAR NEUROBIOLOGY

Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats

(2019) Hsiang-Chien Tseng et al.   NEUROTOXICITY RESEARCH

Dementia

(2018) Seth A. Gale et al.   AMERICAN JOURNAL OF MEDICINE

Non-alcoholic beverage consumption and risk of depression: epidemiological evidence from observational studies

(2018) Dami Kang et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases

(2018) Shu-Qing Chen et al.   MOLECULES

Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster

(2018) Daniel A. Martinez-Perez et al.   NEUROTOXICITY RESEARCH

Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway

(2018) Wang Nan et al.   Biomed Research International

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

(2018) Kazuki Ide et al.   MOLECULES

Inhibition of microbial metabolites of Chinese dark tea on age-related neurodegenerative disorders in Senescence-accelerated mouse prone 8 (SAMP8) mice

(2018) Shuxian Cai et al.   Food & Function

Green Tea, Coffee, and Caffeine Consumption Are Inversely Associated with Self-Report Lifetime Depression in the Korean Population

(2018) Jiwon Kim et al.   Nutrients

Prevalence of Depression in the Community from 30 Countries between 1994 and 2014

(2018) Grace Y. Lim et al.   Scientific Reports

EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer’s Disease

(2018) Neha Atulkumar Singh et al.   Frontiers in Aging Neuroscience

Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic–Pituitary–Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress

(2018) Bombi Lee et al.   JOURNAL OF MEDICINAL FOOD

L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions

(2018) Manjun Shen et al.   PHYTOTHERAPY RESEARCH

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

(2018) Xiao Meng et al.   Nutrients

GABA-modulating bacteria of the human gut microbiota

(2018) Philip Strandwitz et al.   Nature Microbiology

EGCG ameliorates high-fat– and high-fructose–induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

(2017) Yashi Mi et al.   FASEB JOURNAL

Diabetes and Alzheimer’s Disease: Can Tea Phytochemicals Play a Role in Prevention?

(2017) Warnakulasuriya M.A.D.B. Fernando et al.   JOURNAL OF ALZHEIMERS DISEASE

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease

(2017) Qi Xu et al.   JOURNAL OF NUTRITION

Involvement of PKCα and ERK1/2 signaling pathways in EGCG’s protection against stress-induced neural injuries in Wistar rats

(2017) Xiaoling Zhao et al.   NEUROSCIENCE

Green tea effects on cognition, mood and human brain function: A systematic review

(2017) Edele Mancini et al.   PHYTOMEDICINE

Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts

(2017) Sabrina Fechtner et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression

(2017) Maria Daglia et al.   Nutrients

Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies

(2017) Xueying Liu et al.   Oncotarget

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Caffeine in Parkinson's Disease: From Neuroprotection to the Management of Motor and Non-Motor Symptoms

(2017) Rui D.S. Prediger   JOURNAL OF ALZHEIMERS DISEASE

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

(2016) Shinsuke Hidese et al.   ACTA NEUROPSYCHIATRICA

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer’s Disease Treatment

(2016) Babar Ali et al.   CNS & Neurological Disorders-Drug Targets

Inflammation and the microbiome: implications for depressive disorders

(2016) Shawn Hayley et al.   CURRENT OPINION IN PHARMACOLOGY

Tea consumption is inversely associated with depressive symptoms in the elderly: A cross-sectional study in eastern China

(2016) Fu-Dong Li et al.   JOURNAL OF AFFECTIVE DISORDERS

The Neurobiology of Depression: an Integrated Overview from Biological Theories to Clinical Evidence

(2016) F. Ferrari et al.   MOLECULAR NEUROBIOLOGY

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice

(2016) Keiko Unno et al.   PHYTOMEDICINE

Meta-Analysis of the Association between Tea Intake and the Risk of Cognitive Disorders

(2016) Qing-Ping Ma et al.   PLoS One

Screen all for depression

(2016) Mark Sinyor et al.   BMJ-British Medical Journal

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

(2016) Shinsuke Hidese et al.   ACTA NEUROPSYCHIATRICA

Screen all for depression

(2016) Mark Sinyor et al.   BMJ-British Medical Journal

Tea consumption and the risk of depression: A meta-analysis of observational studies

(2015) Xiaoxin Dong et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha: An Emerging Target for Neuroprotection in Parkinson’s Disease

(2015) Nihar Das et al.   CNS & Neurological Disorders-Drug Targets

Neuroprotective Properties of the Standardized Extract fromCamellia sinensis(Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease

(2015) Natália Bitu Pinto et al.   Evidence-based Complementary and Alternative Medicine

Impacts of Gut Bacteria on Human Health and Diseases

(2015) Yu-Jie Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies

(2015) Giuseppe Grosso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression

(2015) Arianna Di Lorenzo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Molecular interaction studies of green tea catechins as multitarget drug candidates for the treatment of Parkinson’s disease: computational and structural insights

(2015) Faizul Azam et al.   NETWORK-COMPUTATION IN NEURAL SYSTEMS

Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro

(2015) Maurício Guilherme Valente Maturana et al.   NEUROTOXICOLOGY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats: A behavioural, biochemical and molecular approach

(2015) Dhivya Bharathi Mathiyazahan et al.   Journal of Functional Foods

Monoamine transporters: insights from molecular dynamics simulations

(2015) Julie Grouleff et al.   Frontiers in Pharmacology

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Tea Consumption and Cognitive Impairment: A Cross-Sectional Study among Chinese Elderly

(2015) Wei Shen et al.   PLoS One

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats

(2014) Kitti Sárközi et al.   NUTRITIONAL NEUROSCIENCE

Green Tea Consumption Affects Cognitive Dysfunction in the Elderly: A Pilot Study

(2014) Kazuki Ide et al.   Nutrients

Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice

(2013) Xia Tian et al.   BRAIN RESEARCH

Consequences of Iron Accumulation in Microglia and its Implications in Neuropathological Conditions

(2013) Gurugirijha Rathnasamy et al.   CNS & Neurological Disorders-Drug Targets

Tea and Health: Studies in Humans

(2013) Naghma Khan et al.   CURRENT PHARMACEUTICAL DESIGN

Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease

(2013) Hui Qi et al.   Geriatrics & Gerontology International

Tea consumption and physical function in older adults: A cross-sectional study

(2013) Tze-Pin Ng et al.   Journal of Nutrition Health & Aging

Green tea catechin leads to global improvement among Alzheimer's disease-related phenotypes in NSE/hAPP-C105 Tg mice

(2013) Hwa Ja Lim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Parkinson's Disease and Tea: A Quantitative Review

(2013) José Luis Barranco Quintana et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Tea Consumption and Depressive Symptoms in Older People in Rural China

(2013) Lei Feng et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

(−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus

(2013) Ning Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Structure-based design and analysis of MAO-B inhibitors for Parkinson’s disease: using in silico approaches

(2013) Pavan Kare et al.   MOLECULAR DIVERSITY

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population

(2013) Ngoc Minh Pham et al.   PUBLIC HEALTH NUTRITION

Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma

(2013) Caroline Menard et al.   Frontiers in Cellular Neuroscience

Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study

(2012) Yasutake Tomata et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Green tea (−)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia

(2012) Regina Biasibetti et al.   BEHAVIOURAL BRAIN RESEARCH

Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease

(2012) A. Anandhan et al.   NEUROSCIENCE

Therapeutic Attenuation of Neuroinflammation and Apoptosis by Black Tea Theaflavin in Chronic MPTP/Probenecid Model of Parkinson’s Disease

(2012) Annadurai Anandhan et al.   NEUROTOXICITY RESEARCH

Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice

(2012) Ulrika Axling et al.   Nutrition & Metabolism

A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease

(2012) Feng-Jiao Li et al.   TheScientificWorldJOURNAL

Relationships between tea and other beverage consumption to work performance and mood

(2011) Janet Bryan et al.   APPETITE

Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease

(2011) Annadurai Anandhan et al.   BRAIN RESEARCH

Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice

(2011) Keiko Unno et al.   FREE RADICAL RESEARCH

Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later

(2011) Emmanuelle Kesse-Guyot et al.   JOURNAL OF NUTRITION

Intake of Japanese and Chinese teas reduces risk of Parkinson’s disease

(2011) Keiko Tanaka et al.   PARKINSONISM & RELATED DISORDERS

Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction

(2011) Takami Kakuda   PHARMACOLOGICAL RESEARCH

Green tea polyphenols produce antidepressant-like effects in adult mice

(2011) Wei-Li Zhu et al.   PHARMACOLOGICAL RESEARCH

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theaflavin digallate inactivates plasminogen activator inhibitor: Could tea help in Alzheimer's disease and obesity?

(2010) Jankun   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exercise, Tea Consumption, and Depression Among Breast Cancer Survivors

(2010) Xiaoli Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

Cognitive function and tea consumption in community dwelling older Chinese in Singapore

(2010) Lei Feng et al.   Journal of Nutrition Health & Aging

Green tea consumption is associated with depressive symptoms in the elderly

(2009) Kaijun Niu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity

(2009) Chang-Yul Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Protective effects of green tea polyphenols on cognitive impairments induced by psychological stress in rats

(2009) Wei-Qiang Chen et al.   BEHAVIOURAL BRAIN RESEARCH

l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

(2009) Tae Il Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice

(2009) Jae Woong Lee et al.   JOURNAL OF NUTRITION

Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress

(2009) Yan Xu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease

(2009) Baolu Zhao   NEUROCHEMICAL RESEARCH

Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease

(2008) Joanne Clark et al.   ANTIOXIDANTS & REDOX SIGNALING

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

(2008) Kavon Rezai-Zadeh et al.   BRAIN RESEARCH

Green tea catechins prevent cognitive deficits caused by Aβ1–40 in rats

(2008) Abdul M. Haque et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols

(2008) Katia Aquilano et al.   NEUROCHEMICAL RESEARCH

Smoking and tea consumption delay onset of Parkinson's disease

(2008) Boris Kandinov et al.   PARKINSONISM & RELATED DISORDERS