Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3′,4′-Dihydroxy-Phenyl)-γ-Valerolactone in Regulating Nrf2-Mediated Gene Expression

In Vitro Microbial Metabolism of (+)-Catechin Reveals Fast and Slow Converters with Individual-Specific Microbial and Metabolite Markers

(2022) Qiqiong Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

(2021) Marjan Talebi et al.   PHYTOTHERAPY RESEARCH

Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans

(2021) Kyung-Soo Chun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Temporal variability in quantitative human gut microbiome profiles and implications for clinical research

(2021) Doris Vandeputte et al.   Nature Communications

Advances in physiological functions and mechanisms of (−)-epicatechin

(2020) Zhihao Qu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Monomeric Flavanols Are More Efficient Substrates for Gut Microbiota Conversion to Hydroxyphenyl‐γ‐Valerolactone Metabolites Than Oligomeric Procyanidins: A Randomized, Placebo‐Controlled Human Intervention Trial

(2020) Wendy J Hollands et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NRF2, a Transcription Factor for Stress Response and Beyond

(2020) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

C-ring cleavage metabolites of catechin and epicatechin enhanced antioxidant activities through intestinal microbiota

(2020) Wanbing Chen et al.   FOOD RESEARCH INTERNATIONAL

Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health

(2020) Marina Fassarella et al.   GUT

Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds

(2020) Chen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interindividual Differences in Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐ O ‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression

(2020) Chen Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dual effects of ascorbic acid on the stability of EGCG by the oxidation product dehydroascorbic acid promoting the oxidation and inhibiting the hydrolysis pathway

(2020) Lin Chen et al.   FOOD CHEMISTRY

Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes of Crohn’s remission patients despite temporal variations in microbial taxa, genomes, and proteomes

(2019) J. Alfredo Blakeley-Ruiz et al.   Microbiome

Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation.

(2019) Tanveer Singh Batth et al.   MOLECULAR & CELLULAR PROTEOMICS

(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury

(2019) Zhenlin Huang et al.   Redox Biology

Quantification of Urinary Phenyl-γ-Valerolactones and Related Valeric Acids in Human Urine on Consumption of Apples

(2019) Andrea Anesi et al.   Metabolites

Effect of heat treatment on bacteriostatic activity and protein profile of bovine whey proteins

(2019) Ling Xiong et al.   FOOD RESEARCH INTERNATIONAL

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

(2018) Gina Borges et al.   MOLECULAR ASPECTS OF MEDICINE

Plant bioactives and redox signaling: (–)-Epicatechin as a paradigm

(2018) Cesar G. Fraga et al.   MOLECULAR ASPECTS OF MEDICINE

The Role of Catechins in Cellular Responses to Oxidative Stress

(2018) Jurga Bernatoniene et al.   MOLECULES

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies

(2018) Javier I. Ottaviani et al.   Scientific Reports

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

Dietary antioxidants as a source of hydrogen peroxide

(2018) Michalina Grzesik et al.   FOOD CHEMISTRY

Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

(2017) Antonio González-Sarrías et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

LPS-induced renal inflammation is prevented by (−)‐epicatechin in rats

(2017) Paula Denise Prince et al.   Redox Biology

Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways

(2016) Tian Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

(−)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways

(2016) Xi Lan et al.   MOLECULAR NEUROBIOLOGY

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

(2016) Javier I. Ottaviani et al.   Scientific Reports

Bioconversion of (−)-Epicatechin, (+)-Epicatechin, (−)-Catechin, and (+)-Catechin by (−)-Epigallocatechin-Metabolizing Bacteria

(2015) Akiko Takagaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects

(2015) Ana Rodriguez-Mateos et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ)

(2015) Karsten Beekmann et al.   Food & Function

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect

(2013) Erik J.B. Ruijters et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress

(2013) Sander C. van der Linden et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models

(2012) Paulo César de Paula Vasconcelos et al.   Evidence-based Complementary and Alternative Medicine

Capability of Lactobacillus plantarum IFPL935 To Catabolize Flavan-3-ol Compounds and Complex Phenolic Extracts

(2012) Fernando Sánchez-Patán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Isolation of catechin-converting human intestinal bacteria

(2011) M. Kutschera et al.   JOURNAL OF APPLIED MICROBIOLOGY

Profile of Plasma and Urine Metabolites after the Intake of Almond [Prunus dulcis (Mill.) D.A. Webb] Polyphenols in Humans

(2009) Mireia Urpi-Sarda et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green Tea Flavan-3-ols: Colonic Degradation and Urinary Excretion of Catabolites by Humans

(2009) Suri Roowi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression

(2008) Małgorzata Muzolf-Panek et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

(2007) Hye-Kyung Na et al.   FOOD AND CHEMICAL TOXICOLOGY