Flavan‐3‐ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid‐beta (1‐42) Levels

Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease

(2020) Roberta Ruotolo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

(2020) Vivian Hook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer’s disease: a pre-clinical study

(2020) Valentina Cecarini et al.   Aging-US

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

(2019) Ena Ladi et al.   JOURNAL OF MEDICINAL CHEMISTRY

ERβ promotes Aβ degradation via the modulation of autophagy

(2019) Yong Wei et al.   Cell Death & Disease

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

(2019) Chunyan Li et al.   Frontiers in Cell and Developmental Biology

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

(2019) Ana Toste Rêgo et al.   MOLECULAR CELL

Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans

(2018) Fabio Castello et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

(2018) Gina Borges et al.   MOLECULAR ASPECTS OF MEDICINE

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Cathepsin B: Active site mapping with peptidic substrates and inhibitors

(2018) Janina Schmitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells

(2017) Keiko Unno et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function

(2017) Laura Mele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells

(2017) Pedro Mena et al.   Journal of Functional Foods

The fine-tuning of proteolytic pathways in Alzheimer’s disease

(2016) Valentina Cecarini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice

(2016) Julien Bensalem et al.   Frontiers in Behavioral Neuroscience

Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction of Furan-Based Dienoxy Silanes: A Chemodivergent Approach to γ-Valerolactone Flavan-3-ol Metabolites and δ-Lactone Analogues

(2015) Claudio Curti et al.   ADVANCED SYNTHESIS & CATALYSIS

Crosstalk between the ubiquitin–proteasome system and autophagy in a human cellular model of Alzheimer's disease

(2012) Valentina Cecarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Identification of an EGCG oxidation derivative with proteasome modulatory activity

(2011) Laura Bonfili et al.   BIOCHIMIE

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

(2010) Mariagioia Zampagni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy protects neuron from Aβ-induced cytotoxicity

(2009) Shih-Ya Hung et al.   Autophagy

Interaction between Phenolics and Gut Microbiota: Role in Human Health

(2009) María V. Selma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

(2008) Natalia B. Nedelsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Natural polyphenols as proteasome modulators and their role as anti-cancer compounds

(2008) Laura Bonfili et al.   FEBS Journal

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

(2008) Michael Groll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY