PBK Model‐Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity

Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies

(2021) Ans Punt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation

(2020) Qianrui Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Predicting the acute liver toxicity of aflatoxin B1 in rats and humans by an in vitro‐in silico testing strategy

(2020) Ixchel Gilbert‐Sandoval et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urinary biomarkers of exposure to the mycoestrogen zearalenone and its modified forms in German adults

(2018) Nurshad Ali et al.   ARCHIVES OF TOXICOLOGY

Biosynthesis and Characterization of Zearalenone-14-Sulfate, Zearalenone-14-Glucoside and Zearalenone-16-Glucoside Using Common Fungal Strains

(2018) Antje Borzekowski et al.   Toxins

Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces

(2018) C. Behr et al.   TOXICOLOGY LETTERS

A critical evaluation of health risk assessment of modified mycotoxins with a special focus on zearalenone

(2018) Nicole Lorenz et al.   Mycotoxin Research

Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences

(2018) Takaya Kutsukake et al.   DRUG METABOLISM AND DISPOSITION

Microbial Ecology along the Gastrointestinal Tract

(2017) Ethan T. Hillman et al.   MICROBES AND ENVIRONMENTS

Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro

(2017) Silvia W. Gratz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats

(2017) Hequn Li et al.   TOXICOLOGY LETTERS

Quercetin metabolism by fecal microbiota from healthy elderly human subjects

(2017) Motoi Tamura et al.   PLoS One

Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models

(2016) Sheila Annie Peters et al.   CLINICAL PHARMACOKINETICS

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women

(2016) Stefanie C. Fleck et al.   FOOD AND CHEMICAL TOXICOLOGY

Surgical Anatomy of the Gastrointestinal Tract and Its Vasculature in the Laboratory Rat

(2016) Katarína Vdoviaková et al.   Gastroenterology Research and Practice

Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites

(2015) Rungnapa Boonpawa et al.   BIOCHEMICAL PHARMACOLOGY

The Characterization of Feces and Urine: A Review of the Literature to Inform Advanced Treatment Technology

(2015) C. Rose et al.   CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY

Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity

(2015) Caroline Frizzell et al.   TOXICOLOGY IN VITRO

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

(2014) Jochem Louisse et al.   ARCHIVES OF TOXICOLOGY

In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites

(2014) Shihua Xing et al.   FITOTERAPIA

Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays

(2014) José-Manuel Molina-Molina et al.   FOOD AND CHEMICAL TOXICOLOGY

Physiologically-Based Toxicokinetic Modeling of Zearalenone and Its Metabolites: Application to the Jersey Girl Study

(2014) Dwaipayan Mukherjee et al.   PLoS One

Fecal microbial metabolism of polyphenols and its effects on human gut microbiota

(2013) Shanthi G. Parkar et al.   ANAEROBE

Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model

(2013) Xiaoxia Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone

(2013) Benedikt Warth et al.   TOXICOLOGY LETTERS

Fast and reproducible chemical synthesis of zearalenone-14-β,D-glucuronide

(2012) H. Mikula et al.   World Mycotoxin Journal

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

(2011) H. E. Cubitt et al.   DRUG METABOLISM AND DISPOSITION

Urinary mycoestrogens, body size and breast development in New Jersey girls

(2011) Elisa V. Bandera et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples

(2010) W. Brand et al.   DRUG METABOLISM AND DISPOSITION

Glucuronidation of zearalenone, zeranol and four metabolites in vitro: Formation of glucuronides by various microsomes and human UDP-glucuronosyltransferase isoforms

(2010) Erika Pfeiffer et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Absorption and metabolism of the mycotoxin zearalenone and the growth promotor zeranol in Caco-2 cells in vitro

(2010) Erika Pfeiffer et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Zearalenone and its metabolites as endocrine disrupting chemicals

(2010) M. Metzler et al.   World Mycotoxin Journal

Oestrogenic mycotoxin exposures and precocious pubertal development

(2009) F. Massart et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

In Vitro Cytochrome P450 Formation of a Mono-Hydroxylated Metabolite of Zearalenone Exhibiting Estrogenic Activities: Possible Occurrence of This Metabolite in Vivo

(2009) Frederique Bravin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disposition, Oral Bioavailability, and Tissue Distribution of Zearalenone in Rats at Various Dose Levels

(2009) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Evaluation of small bowel measurement in alive patients

(2008) Mehrdad Hosseinpour et al.   SURGICAL AND RADIOLOGIC ANATOMY

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

(2008) Ans Punt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systematic Studies on the Paracellular Permeation of Model Permeants and Oligonucleotides in the Rat Small Intestine with Chenodeoxycholate as Enhancer

(2007) Keiko Tsutsumi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES