A Screening of Native (Poly)phenols and Gut‐Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan‐3‐ol Metabolite

Challenges of applying multicellular tumor spheroids in preclinical phase

(2021) Se Jik Han et al.   Cancer Cell International

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

(2021) Jing Zhao et al.   Nature Communications

Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

(2021) Atsuo Nakamura et al.   Nature Communications

Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells

(2021) Sara Dobani et al.   Redox Biology

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions

(2020) Josep Rubert et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

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(2020) Ross J. Porter et al.   BRITISH JOURNAL OF CANCER

Inhibition of Ovarian Cancer Cell Spheroid Formation by Synthetic Peptides Derived from Nectin-4

(2020) Kristin L.M. Boylan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer

(2020) Thanusha Ganesan et al.   Nutrients

Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

(2020) Colin D Kay et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds

(2020) Chen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolomic Changes after Coffee Consumption: New Paths on the Block

(2020) Claudia Favari et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

(2020) Gizem Calibasi-Kocal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

(2019) Andrew Maltez Thomas et al.   NATURE MEDICINE

Metabolic pathways regulating colorectal cancer initiation and progression

(2019) Sofia La Vecchia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rethinking the Mechanism of the Health Benefits of Proanthocyanidins: Absorption, Metabolism, and Interaction with Gut Microbiota

(2019) Wenyang Tao et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Reconstructing functional networks in the human intestinal tract using synthetic microbiomes

(2019) Sudarshan A Shetty et al.   CURRENT OPINION IN BIOTECHNOLOGY

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

(2019) Dharambir Kashyap et al.   SEMINARS IN CANCER BIOLOGY

Catechin and Procyanidin B2 Modulate the Expression of Tight Junction Proteins but Do Not Protect from Inflammation-Induced Changes in Permeability in Human Intestinal Cell Monolayers

(2019) Massimiliano G. Bianchi et al.   Nutrients

Quantification of Urinary Phenyl-γ-Valerolactones and Related Valeric Acids in Human Urine on Consumption of Apples

(2019) Andrea Anesi et al.   Metabolites

The Intestinal Microbiota in Colorectal Cancer

(2018) Herbert Tilg et al.   CANCER CELL

Targeting Ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: lessons learned from clinical trials

(2018) Seyed Fazel Nabavi et al.   CANCER LETTERS

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes

(2018) Pedro Mena et al.   EUROPEAN JOURNAL OF NUTRITION

Host: Microbiome co -metabolic processing of dietary polyphenols – An acute, single blinded, cross-over study with different doses of apple polyphenols in healthy subjects

(2018) Kajetan Trošt et al.   FOOD RESEARCH INTERNATIONAL

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming

(2018) Qingran Li et al.   MOLECULAR & CELLULAR PROTEOMICS

A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy

(2018) Viktoryia Sidarovich et al.   MOLECULAR CANCER THERAPEUTICS

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

(2018) Jia Yang et al.   Protein & Cell

Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid

(2018) Samantha Yuille et al.   PLoS One

A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer

(2018) Preethi Ravindranathan et al.   Scientific Reports

Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation

(2018) Karam Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

(2018) Caihong Yi et al.   RNA Biology

2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine

(2018) Yuan Liu et al.   Cells

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

Food Components in Health Promotion and Disease Prevention

(2017) Wolfgang Langhans   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hydroxytyrosol and the Colonic Metabolites Derived from Virgin Olive Oil Intake Induce Cell Cycle Arrest and Apoptosis in Colon Cancer Cells

(2017) Maria-Carmen López de las Hazas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1

(2017) Tomohiro Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat

(2017) Tzu-Ying Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine

(2017) Nicoletta Brindani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antioxidant polyphenols in cancer treatment: Friend, foe or foil?

(2017) Gian Luigi Russo et al.   SEMINARS IN CANCER BIOLOGY

Effects of Commercial Apple Varieties on Human Gut Microbiota Composition and Metabolic Output Using an In Vitro Colonic Model

(2017) Athanasios Koutsos et al.   Nutrients

The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers

(2017) Yui-Ping Weng et al.   Oncotarget

Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology

(2016) Tim Y. Hou et al.   Annual Review of Nutrition

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

(2016) Eswar Shankar et al.   SEMINARS IN CANCER BIOLOGY

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

(2016) Linda S. Zhang et al.   Genome Medicine

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

(2016) Javier I. Ottaviani et al.   Scientific Reports

Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction of Furan-Based Dienoxy Silanes: A Chemodivergent Approach to γ-Valerolactone Flavan-3-ol Metabolites and δ-Lactone Analogues

(2015) Claudio Curti et al.   ADVANCED SYNTHESIS & CATALYSIS

Fruit and vegetables and cancer risk: a review of southern European studies

(2015) Federica Turati et al.   BRITISH JOURNAL OF NUTRITION

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Microscopy-Based High-Content Screening

(2015) Michael Boutros et al.   CELL

The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

(2015) C. H. Little et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Flavanol-Enriched Cocoa Powder Alters the Intestinal Microbiota, Tissue and Fluid Metabolite Profiles, and Intestinal Gene Expression in Pigs

(2015) Saebyeol Jang et al.   JOURNAL OF NUTRITION

Carcinogenicity of consumption of red and processed meat

(2015) Véronique Bouvard et al.   LANCET ONCOLOGY

Comparative biokinetics and metabolism of pure monomeric, dimeric, and polymeric flavan-3-ols: A randomized cross-over study in humans

(2015) Stefanie Wiese et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MMP7 Is Required to Mediate Cell Invasion and Tumor Formation upon Plakophilin3 Loss

(2015) Srikanta Basu et al.   PLoS One

The Role of Matrix Metalloproteinases in Colorectal Cancer

(2014) Anan Said et al.   Cancers

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Persistence of Anticancer Activity in Berry Extracts after Simulated Gastrointestinal Digestion and Colonic Fermentation

(2012) Emma M. Brown et al.   PLoS One

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

(2012) Kristel Kemper et al.   STEM CELLS

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites

(2010) Maria Monagas et al.   Food & Function

Proanthocyanidins and the risk of colorectal cancer in Italy

(2009) Marta Rossi et al.   CANCER CAUSES & CONTROL

A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota

(2009) Stavroula Stoupi et al.   MOLECULAR NUTRITION & FOOD RESEARCH