Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

(2019) Jia Ning et al.   ARCHIVES OF TOXICOLOGY

Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects

(2019) Baltasar Mayo et al.   Nutrients

Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat

(2018) Lu Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics

(2018) C. Behr et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Microbial Ecology along the Gastrointestinal Tract

(2017) Ethan T. Hillman et al.   MICROBES AND ENVIRONMENTS

Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity

(2017) Marije Strikwold et al.   TOXICOLOGICAL SCIENCES

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

(2016) Marije Strikwold et al.   ARCHIVES OF TOXICOLOGY

Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling

(2016) Ans Punt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data

(2016) Jochem Louisse et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I

(2016) Rozaini Abdullah et al.   FOOD AND CHEMICAL TOXICOLOGY

Long-term kinetics of daidzein and its main metabolites in human equol-producers after soymilk intake: identification of equol-conjugates by UPLC-orbitrap-MS and influence of the number of transforming bacteria on plasma kinetics

(2016) Claudio Gardana et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations

(2015) Ala′ A.A. Al-Subeihi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ)

(2015) Karsten Beekmann et al.   Food & Function

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

(2014) Jochem Louisse et al.   ARCHIVES OF TOXICOLOGY

LC-MS/MS determination and pharmacokinetics study of puerarin and daidzein in rat plasma after oral administration of Gegenqinlian decoction and Radix Puerariae extract

(2014) Yifan Zhang et al.   Pharmacognosy Magazine

Identification and Expression of Genes Involved in the Conversion of Daidzein and Genistein by the Equol-Forming Bacterium Slackia isoflavoniconvertens

(2013) Christine Schröder et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

(2013) Marije Strikwold et al.   ARCHIVES OF TOXICOLOGY

Transport Mechanisms for Soy Isoflavones and Microbial Metabolites Dihydrogenistein and Dihydrodaidzein Across Monolayers and Membranes

(2013) Shoko KOBAYASHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Gut bacterial microbiota and obesity

(2013) M. Million et al.   CLINICAL MICROBIOLOGY AND INFECTION

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models

(2013) Mohammed A. Islam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress

(2013) Sander C. van der Linden et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Identification of a Novel Dihydrodaidzein Racemase Essential for Biosynthesis of Equol from Daidzein in Lactococcus sp. Strain 20-92

(2012) Yoshikazu Shimada et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Elucidation of the metabolic pathway of S-equol in rat, monkey and man

(2012) Richard J. Schwen et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxicokinetics and lack of uterotropic effect of orally administered S-equol

(2012) Richard J. Schwen et al.   FOOD AND CHEMICAL TOXICOLOGY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Developing a metagenomic view of xenobiotic metabolism

(2012) Henry J. Haiser et al.   PHARMACOLOGICAL RESEARCH

Enhanced Intestinal Absorption of Daidzein by Borneol/Menthol Eutectic Mixture and Microemulsion

(2011) Qi Shen et al.   AAPS PHARMSCITECH

Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk

(2011) Kenneth DR Setchell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Identification of an Enzyme System for Daidzein-to-Equol Conversion in Slackia sp. Strain NATTS

(2011) Hirokazu Tsuji et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

(2011) H. E. Cubitt et al.   DRUG METABOLISM AND DISPOSITION

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research

(2011) Ivonne M. C. M. Rietjens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease

(2011) S. Greenblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning and Expression of a Novel NADP(H)-Dependent Daidzein Reductase, an Enzyme Involved in the Metabolism of Daidzein, from Equol-Producing Lactococcus Strain 20-92

(2010) Y. Shimada et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Equol: History, Chemistry, and Formation

(2010) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism

(2010) A.M. Sotoca et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Isolation of a Human Intestinal Bacterium Capable of Daidzein and Genistein Conversion

(2009) A. Matthies et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Relative Developmental Toxicity of Glycol Ether Alkoxy Acid Metabolites in the Embryonic Stem Cell Test as compared with the In Vivo Potency of their Parent Compounds

(2009) Esther de Jong et al.   TOXICOLOGICAL SCIENCES

Conversion of Daidzein and Genistein by an Anaerobic Bacterium Newly Isolated from the Mouse Intestine

(2008) A. Matthies et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERα/ERβ ratio

(2008) A.M. Sotoca et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY