Engineering metabolism to modulate immunity

Composite Hydrogel for Spatiotemporal Lipid Intervention of Tumor Milieu

(2023) Jia Ma et al.   ADVANCED MATERIALS

Delivery Route Considerations for Designing Antigen‐Specific Biomaterial Strategies to Combat Autoimmunity

(2023) Marian A. Ackun-Farmmer et al.   Advanced Nanobiomed Research

Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

(2023) Kuniyuki Aso et al.   Nature Communications

Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

(2023) Joshua M. Gammon et al.   Nature Communications

Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

(2022) Xing-Lan Ding et al.   BIOMATERIALS

Microenvironmental influences on T cell immunity in cancer and inflammation

(2022) Darren R. Heintzman et al.   Cellular & Molecular Immunology

Diet, lipids, and antitumor immunity

(2022) Hannah Prendeville et al.   Cellular & Molecular Immunology

Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology

(2022) Hongbo Chi   Cellular & Molecular Immunology

Drug delivery for metabolism targeted cancer immunotherapy

(2022) Taravat Khodaei et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of molybdenum in material immunomodulation and periodontal wound healing: Targeting immunometabolism and mitochondrial function for macrophage modulation

(2022) Xiao-Tao He et al.   BIOMATERIALS

Tuning the surface potential to reprogram immune microenvironment for bone regeneration

(2022) Mei Li et al.   BIOMATERIALS

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

(2022) Kalpita R. Karan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications

(2022) Shrey A. Shah et al.   Frontiers in Immunology

Outcomes Following Treatment for Adenosine Deaminase Deficient Severe Combined Immunodeficiency: A Report from the PIDTC

(2022) Geoffrey D.E. Cuvelier et al.   BLOOD

The effect of HIF on metabolism and immunity

(2022) Cormac T. Taylor et al.   Nature Reviews Nephrology

Nanotechnology for Enhanced Cytoplasmic and Organelle Delivery of Bioactive Molecules to Immune Cells

(2022) Xiaoyu Li et al.   PHARMACEUTICAL RESEARCH

Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

(2022) Guihong Lu et al.   Nature Communications

Co-transplantation of Islets-Laden Microgels and Biodegradable O2-Generating Microspheres for Diabetes Treatment

(2022) Hanhao Huang et al.   ACS Applied Materials & Interfaces

Rapamycin-encapsulated costimulatory ICOS/CD40L-bispecific nanoparticles restrict pathogenic helper T-B-cell interactions while in situ suppressing mTOR for lupus treatment

(2022) Jiali Zhang et al.   BIOMATERIALS

Functional gelatin hydrogel scaffold with degraded-release of glutamine to enhance cellular energy metabolism for cartilage repair

(2022) Ran Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metabolic communication in the tumour–immune microenvironment

(2022) Kung-Chi Kao et al.   NATURE CELL BIOLOGY

A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair

(2022) Beimin Tian et al.   International Journal of Oral Science

Suppression of Autoimmune Rheumatoid Arthritis with Hybrid Nanoparticles That Induce B and T Cell Tolerance to Self-Antigen

(2022) Katarzyna A. Brzezicka et al.   ACS Nano

High serum LDH and liver metastases are the dominant predictors of primary cancer resistance to anti-PD(L)1 immunotherapy

(2022) Laurent Dercle et al.   EUROPEAN JOURNAL OF CANCER

Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis

(2022) Hee Su Sohn et al.   Science Advances

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

(2021) Mainak Chakraborty et al.   Cell Reports

The cancer metabolic reprogramming and immune response

(2021) Longzheng Xia et al.   Molecular Cancer

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

(2021) Joshua J. Rennick et al.   Nature Nanotechnology

Glucose oxidase: Applications, sources, and recombinant production

(2021) Seyyed Hossein Khatami et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

(2021) Shancheng Yu et al.   Frontiers in Chemistry

Perspectives on immunometabolism at the biomaterials interface

(2021) Sabrina L. Macias et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

(2021) Hamza Atcha et al.   Nature Communications

Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity

(2021) Daniel Tomé   Nutrition & Diabetes

Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

(2021) Indumathi Manoharan et al.   Frontiers in Immunology

ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia

(2021) Petr O. Ilyinskii et al.   Molecular Therapy-Methods & Clinical Development

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Mitochondria-Targeted Nanomedicine for Enhanced Efficacy of Cancer Therapy

(2021) Yan Gao et al.   Frontiers in Bioengineering and Biotechnology

Enhanced Cancer Starvation Therapy Based on Glucose Oxidase/3-Methyladenine-Loaded Dendritic Mesoporous OrganoSilicon Nanoparticles

(2021) Fan Wu et al.   Biomolecules

Tailoring the physicochemical properties of nanomaterials for immunomodulation

(2021) Junjie Deng et al.   ADVANCED DRUG DELIVERY REVIEWS

Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice

(2021) Joslyn L. Mangal et al.   BIOMATERIALS

The Nanoparticle-Enabled Success of COVID-19 mRNA Vaccines and the Promise of Microneedle Platforms for Pandemic Vaccine Response

(2021) Senta M. Kapnick   DNA AND CELL BIOLOGY

Immunoengineering Biomaterials in Cell-Based Therapy for Type 1 Diabetes

(2021) Hossein Derakhshankhah et al.   Tissue Engineering Part B-Reviews

A bioinspired scaffold for rapid oxygenation of cell encapsulation systems

(2021) Long-Hai Wang et al.   Nature Communications

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

(2021) Jennifer L. Cannons et al.   Cell Reports

Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

(2021) Jianlin Zuo et al.   Frontiers in Immunology

Lactate in the tumour microenvironment: From immune modulation to therapy

(2021) Zi-Hao Wang et al.   EBioMedicine

Synthetic Materials that Affect the Extracellular Matrix via Cellular Metabolism and Responses to a Metabolic State

(2021) Mireille M.J.P.E. Sthijns et al.   Frontiers in Bioengineering and Biotechnology

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

(2020) Niklas Mejhert et al.   MOLECULAR CELL

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling

(2020) Qiu-Ping Liu et al.   Cancers

The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis

(2020) Sen Wang et al.   BMC CANCER

Signaling networks in immunometabolism

(2020) Jordy Saravia et al.   CELL RESEARCH

Durotaxis

(2020) Raimon Sunyer et al.   CURRENT BIOLOGY

Immunometabolism: From basic mechanisms to translation

(2020) Liza Makowski et al.   IMMUNOLOGICAL REVIEWS

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

(2020) Hongling Huang et al.   IMMUNOLOGICAL REVIEWS

Oxygen-releasing nanofibers for breathable bone tissue engineering application

(2020) Sajedeh Khorshidi et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications

(2020) Gopinathan Janarthanan et al.   JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Amino Assets: How Amino Acids Support Immunity

(2020) Beth Kelly et al.   Cell Metabolism

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

Metabolic signaling in T cells

(2020) Justin A. Shyer et al.   CELL RESEARCH

Mechanosensing through YAP controls T cell activation and metabolism

(2020) Kevin P. Meng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

(2020) Luis Felipe Campesato et al.   Nature Communications

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

(2020) Daniel Blumenthal et al.   eLife

Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

(2020) Maxim Jestin et al.   Molecular Metabolism

Glutamine reliance in cell metabolism

(2020) Hee Chan Yoo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Systemic Immunometabolism: Challenges and Opportunities

(2020) Alexander Lercher et al.   IMMUNITY

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

(2020) Pranvera Sadiku et al.   Cell Metabolism

Fabrication of oxygen and calcium releasing microcarriers with different internal structures for bone tissue engineering: Solid filled versus hollow microparticles

(2020) Elham Mohseni-Vadeghani et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Arginine depletion as a therapeutic approach for patients with COVID-19

(2020) Joseph M. Grimes et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

(2020) Vijaykumar S. Meli et al.   Science Advances

Extracellular Citrate Fuels Cancer Cell Metabolism and Growth

(2020) Sebastian Haferkamp et al.   Frontiers in Cell and Developmental Biology

Exploring the evolutionary roots and physiological function of itaconate

(2020) Thekla Cordes et al.   CURRENT OPINION IN BIOTECHNOLOGY

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

(2019) Steve Stegen et al.   NATURE

Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview

(2019) Mariia Lunova et al.   Cancers

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

(2019) Patrizia Romani et al.   NATURE CELL BIOLOGY

Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose

(2019) Shaoming Jin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Material stiffness influences the polarization state, function and migration mode of macrophages

(2019) Rukmani Sridharan et al.   Acta Biomaterialia

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Solution processable liquid metal nanodroplets by surface-initiated atom transfer radical polymerization

(2019) Jiajun Yan et al.   Nature Nanotechnology

Hypoxia Selectively Impairs CAR-T Cells In Vitro

(2019) Robert Berahovich et al.   Cancers

Rho GTPases—Emerging Regulators of Glucose Homeostasis and Metabolic Health

(2019) Møller et al.   Cells

Targeting metabolism to regulate immune responses in autoimmunity and cancer

(2019) Chirag H. Patel et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

The Immunomodulatory Potential of the Metabolite Itaconate

(2019) Alexander Hooftman et al.   TRENDS IN IMMUNOLOGY

Biomaterial‐Based Metabolic Regulation in Regenerative Engineering

(2019) Chuying Ma et al.   Advanced Science

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

(2019) Fan Gao et al.   ADVANCED MATERIALS

Biomaterials as Tools to Decode Immunity

(2019) Haleigh B. Eppler et al.   ADVANCED MATERIALS

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Oxygenation of the Transplanted Kidney

(2019) Christian Rosenberger et al.   SEMINARS IN NEPHROLOGY

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

(2019) Anna Galstyan et al.   Nature Communications

Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

(2019) Donatella Granchi et al.   Nutrients

The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy

(2019) Rikito Endo et al.   Scientific Reports

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Oxygen-Releasing Antioxidant Cryogel Scaffolds with Sustained Oxygen Delivery for Tissue Engineering Applications

(2018) Parvaiz A. Shiekh et al.   ACS Applied Materials & Interfaces

Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy

(2018) Rui Zhang et al.   BIOMATERIALS

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism

(2018) Senta M. Kapnick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Scavenging of reactive oxygen and nitrogen species with nanomaterials

(2018) Carolina A. Ferreira et al.   Nano Research

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

(2018) Cyril Corbet et al.   Nature Communications

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

(2018) Riley P. Allen et al.   ACS Biomaterials-Science & Engineering

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

(2018) Jinrong Peng et al.   Advanced Science

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

(2018) Riley P. Allen et al.   ACS Biomaterials Science & Engineering

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

(2018) William J. Sullivan et al.   CELL

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

(2018) Hua Wang et al.   NATURE MATERIALS

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

(2018) Samuel A. Smith et al.   BIOCONJUGATE CHEMISTRY

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

(2018) Andrew G Cox et al.   EMBO JOURNAL

Citrate-based materials fuel human stem cells by metabonegenic regulation

(2018) Chuying Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-Based Biomaterials for Regeneration and Therapy

(2018) Yingchao Su et al.   TRENDS IN BIOTECHNOLOGY

Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo

(2017) Xiaoying Lei et al.   International Journal of Nanomedicine

AMPK negatively regulates tensin-dependent integrin activity

(2017) Maria Georgiadou et al.   JOURNAL OF CELL BIOLOGY

Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients

(2017) Qi Wu et al.   JOURNAL OF IMMUNOLOGY

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

(2017) J. Olechnowicz et al.   Journal of Physiological Sciences

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Anticancer Effect of α-Tocopheryl Succinate Delivered by Mitochondria-Targeted Mesoporous Silica Nanoparticles

(2016) Qiuyu Qu et al.   ACS Applied Materials & Interfaces

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

(2016) James I. Andorko et al.   Acta Biomaterialia

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

(2016) Wenpei Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation

(2016) Leila Montazeri et al.   BIOMATERIALS

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Hypoxia-inducible factor 1 in autoimmune diseases

(2016) Wei Deng et al.   CELLULAR IMMUNOLOGY

Molybdenum cofactor and human disease

(2016) Guenter Schwarz   CURRENT OPINION IN CHEMICAL BIOLOGY

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a multifunctional envelope-type nano device and its application to nanomedicine

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of lipids in the metabolism and activation of immune cells

(2016) Merla J. Hubler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Validation of a Strategy for Cancer Therapy: Delivering Aminoglycoside Drugs to Mitochondria in HeLa Cells

(2016) Jiro Abe et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of copper-doped silicate 13–93 bioactive glass scaffolds on the response of MC3T3-E1 cells in vitro and on bone regeneration and angiogenesis in rat calvarial defects in vivo

(2016) Yinan Lin et al.   Materials Science & Engineering C-Materials for Biological Applications

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

(2016) Junyoung O Park et al.   Nature Chemical Biology

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs

(2016) Min-Jung Park et al.   Translational Research

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering?

(2016) Mazaher Gholipourmalekabadi et al.   TRENDS IN BIOTECHNOLOGY

Graphene Oxide-Copper Nanocomposite-Coated Porous CaP Scaffold for Vascularized Bone Regeneration via Activation of Hif-1α

(2016) Wenjie Zhang et al.   Advanced Healthcare Materials

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Oxygen delivering biomaterials for tissue engineering

(2016) Ashley L. Farris et al.   Journal of Materials Chemistry B

Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases

(2016) Zaidoon Al-Jaderi et al.   Frontiers in Immunology

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

(2015) Srinivas Ramishetti et al.   ACS Nano

Citrate-Based Biomaterials and Their Applications in Regenerative Engineering

(2015) Richard T. Tran et al.   Annual Review of Materials Research

Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response

(2015) Lei Jiang et al.   BIOMATERIALS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses

(2015) M. J. Ashbrook et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo

(2015) Yingyue Zeng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Mitochondrial delivery of Coenzyme Q 10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

(2015) Yuma Yamada et al.   JOURNAL OF CONTROLLED RELEASE

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metallic implant biomaterials

(2015) Qizhi Chen et al.   MATERIALS SCIENCE & ENGINEERING R-REPORTS

Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype

(2015) Jiujie Cui et al.   MEDICAL ONCOLOGY

Endosymbiotic theories for eukaryote origin

(2015) William F. Martin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Hypoxia Inducible Factor-Stabilizing Bioactive Glasses for Directing Mesenchymal Stem Cell Behavior

(2015) Maria M. Azevedo et al.   TISSUE ENGINEERING PART A

The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate

(2015) Sean Marrache et al.   Chemical Science

Transformable liquid-metal nanomedicine

(2015) Yue Lu et al.   Nature Communications

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Development of injectable citrate-based bioadhesive bone implants

(2015) Denghui Xie et al.   Journal of Materials Chemistry B

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Oxygen supply to encapsulated therapeutic cells

(2014) Clark K. Colton   ADVANCED DRUG DELIVERY REVIEWS

The Role of Hypoxia-Inducible Factors in Organ Donation and Transplantation: The Current Perspective and Future Opportunities

(2014) M. Z. Akhtar et al.   AMERICAN JOURNAL OF TRANSPLANTATION

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-  Responses in Tumor-Associated Macrophages

(2014) Y. Zhang et al.   CANCER RESEARCH

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Multifunctional Enveloped Mesoporous Silica Nanoparticles for Subcellular Co-delivery of Drug and Therapeutic Peptide

(2014) Guo-Feng Luo et al.   Scientific Reports

Citric Acid-based Hydroxyapatite Composite Scaffolds Enhance Calvarial Regeneration

(2014) Dawei Sun et al.   Scientific Reports

Ex Vivo Programming of Dendritic Cells by Mitochondria-Targeted Nanoparticles to Produce Interferon-Gamma for Cancer Immunotherapy

(2013) Sean Marrache et al.   ACS Nano

Multifunctional nanoparticles for brain tumor imaging and therapy

(2013) Yu Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

(2013) Xinyi Jiang et al.   BIOMATERIALS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Peptide-based carbon nanotubes for mitochondrial targeting

(2013) Alessia Battigelli et al.   Nanoscale

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

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