HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

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Differentiation of Effector CD4 T Cell Populations

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Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

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Metabolism in T cell activation and differentiation

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Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

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The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

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The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

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Anergic T Cells Are Metabolically Anergic

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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mTOR regulates memory CD8 T-cell differentiation

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

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The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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Infectious tolerance via the consumption of essential amino acids and mTOR signaling

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Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

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LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

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Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Integration of metabolism and inflammation by lipid-activated nuclear receptors

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

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