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Title
The effect of HIF on metabolism and immunity
Authors
Keywords
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Journal
Nature Reviews Nephrology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-06-21
DOI
10.1038/s41581-022-00587-8
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Note: Only part of the references are listed.- Fate‐mapping of erythropoietin‐producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality
- (2022) Sophie L. Dahl et al. Acta Physiologica
- Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis
- (2022) Silvio Danese et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The asparagine hydroxylase FIH – a unique oxygen sensor
- (2022) Yulia L. Volkova et al. ANTIOXIDANTS & REDOX SIGNALING
- The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut
- (2022) Ewelina Krzywinska et al. JOURNAL OF EXPERIMENTAL MEDICINE
- HIF2α is a Direct Regulator of Neutrophil Motility
- (2021) Sundary Sormendi et al. BLOOD
- Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
- (2021) Holger Scholz et al. Nature Reviews Nephrology
- The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
- (2021) Fang Zheng et al. Nature Communications
- Hypoxia-inducible factor–1α–dependent induction of miR122 enhances hepatic ischemia tolerance
- (2021) Cynthia Ju et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF‑1α protein SUMOylation is an important protective mechanism of action of hypothermia in hypoxic cardiomyocytes
- (2021) Huaqin Liu et al. Molecular Medicine Reports
- Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease
- (2021) Volker H. Haase Kidney International Supplements
- NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
- (2021) Michal Sobecki et al. Nature Communications
- Hypoxia and Inflammation: Insights From High-Altitude Physiology
- (2021) Kathy Pham et al. Frontiers in Physiology
- The blood-gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung
- (2021) Milad Shirvaliloo Tissue Barriers
- Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin‐expressing cells of mouse kidneys
- (2021) Katharina A. E. Broeker et al. JOURNAL OF PHYSIOLOGY-LONDON
- Hypoxia and Innate Immunity: Keeping Up with the HIFsters
- (2020) Sean P. Colgan et al. Annual Review of Immunology
- Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
- (2020) Pearl Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria
- (2020) Silverio Perrotta et al. NEW ENGLAND JOURNAL OF MEDICINE
- PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
- (2020) Gommaar D’Hulst et al. Nature Communications
- Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism
- (2020) Antonio Bouthelier et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
- (2020) Ping-Min Chen et al. Science Translational Medicine
- PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle
- (2020) Haejin Yoon et al. Cell Metabolism
- If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease
- (2020) Ffion R. Hammond et al. FEBS Journal
- Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
- (2020) Rashi Singhal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia in chronic kidney disease: towards a paradigm shift?
- (2020) Anna Faivre et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
- (2020) Peter S. J. Bailey et al. Nature Communications
- The Role of HIF in Immunity and Inflammation
- (2020) Anne F. McGettrick et al. Cell Metabolism
- Hypoxia-inducible factors and obstructive sleep apnea
- (2020) Nanduri R. Prabhakar et al. JOURNAL OF CLINICAL INVESTIGATION
- Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
- (2020) S. J. Kierans et al. JOURNAL OF PHYSIOLOGY-LONDON
- LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α
- (2020) Linguo Xu et al. ONCOGENE
- The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
- (2020) Poonam Dhillon et al. Cell Metabolism
- The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
- (2020) Adam Albanese et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Silent hypoxaemia in COVID‐19 patients
- (2020) Tatum S. Simonson et al. JOURNAL OF PHYSIOLOGY-LONDON
- HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis
- (2019) Florinda Meléndez-Rodríguez et al. Cell Reports
- Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization
- (2019) Lisha Xiang et al. Cell Death & Disease
- Hypoxia induces rapid changes to histone methylation and reprograms chromatin
- (2019) Michael Batie et al. SCIENCE
- Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
- (2019) Abhishek A. Chakraborty et al. SCIENCE
- Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response
- (2019) Pranvera Sadiku et al. EMBO REPORTS
- Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
- (2019) Fei Chen et al. NATURE CELL BIOLOGY
- Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
- (2019) Matteo Morotti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of hypoxia signalling: new implications for nephrology
- (2019) Johannes Schödel et al. Nature Reviews Nephrology
- Mechanisms and consequences of oxygen- and carbon dioxide-sensing in mammals
- (2019) Eoin P Cummins et al. PHYSIOLOGICAL REVIEWS
- Physiology of the Carotid Body: From Molecules to Disease
- (2019) Patricia Ortega-Sáenz et al. Annual Review of Physiology
- Myeloid HIF‐1α regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection
- (2019) Mariana Resende et al. IMMUNOLOGY
- Now a Nobel gas: oxygen
- (2019) Joachim Fandrey et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
- (2019) Hee Chan Yoo et al. Cell Metabolism
- Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression
- (2019) Ilaria M.C. Orlando et al. HAEMATOLOGICA
- The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat counteracts alterations in renal energy metabolism in the early stages of diabetic kidney disease
- (2019) Sho Hasegawa et al. KIDNEY INTERNATIONAL
- Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
- (2018) Debangshu Samanta et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Source and microenvironmental regulation of erythropoietin in the kidney
- (2018) Karen A. Nolan et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- The role of hypoxia-inducible factors in carotid body (patho) physiology
- (2018) Gregg L. Semenza et al. JOURNAL OF PHYSIOLOGY-LONDON
- Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
- (2018) Xianyi Meng et al. Nature Communications
- Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
- (2018) James A Smythies et al. EMBO REPORTS
- Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish
- (2018) Nikolay V. Ogryzko et al. JOURNAL OF IMMUNOLOGY
- Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype
- (2018) Faik Imeri et al. KIDNEY INTERNATIONAL
- The functional interplay between the HIF pathway and the ubiquitin system – more than a one-way road
- (2017) Julia Günter et al. EXPERIMENTAL CELL RESEARCH
- Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver
- (2017) Seonghwan Hwang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-sensitive pathways in intestinal inflammation
- (2017) Eric Brown et al. JOURNAL OF PHYSIOLOGY-LONDON
- The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
- (2017) Mircea Ivan et al. MOLECULAR CELL
- HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
- (2017) Weinan Du et al. Nature Communications
- The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels
- (2017) Anna L Miles et al. eLife
- Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of AtherosclerosisSignificance
- (2016) Lea Rahtu-Korpela et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis
- (2016) D. Samanta et al. CANCER RESEARCH
- HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival
- (2016) Steve Stegen et al. Cell Metabolism
- Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia
- (2016) Andrew C. Selfridge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-dependent regulation of inflammatory pathways in immune cells
- (2016) Cormac T. Taylor et al. JOURNAL OF CLINICAL INVESTIGATION
- Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
- (2016) Hanako Kobayashi et al. JOURNAL OF CLINICAL INVESTIGATION
- Inverse association between altitude and obesity: A prevalence study among andean and low-altitude adult individuals of Peru
- (2016) Orison O. Woolcott et al. Obesity
- The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches
- (2016) Marco Mineo et al. Cell Reports
- FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
- (2016) Carsten C. Scholz et al. PLOS BIOLOGY
- Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway
- (2015) Valéry L. Payen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Skeletal muscle hypoxia-inducible factor-1 and exercise
- (2015) Malene E. Lindholm et al. EXPERIMENTAL PHYSIOLOGY
- Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α
- (2015) Kyle L. Flannigan et al. FASEB JOURNAL
- Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
- (2015) Murtaza M. Tambuwala et al. JOURNAL OF CONTROLLED RELEASE
- Myeloid HIF-1 Is Protective inHelicobacter pylori–Mediated Gastritis
- (2015) Pavle Matak et al. JOURNAL OF IMMUNOLOGY
- Anaemia in kidney disease: harnessing hypoxia responses for therapy
- (2015) Mark J. Koury et al. Nature Reviews Nephrology
- Destruction of a distal hypoxia response element abolishestrans-activation of thePAG1gene mediated by HIF-independent chromatin looping
- (2015) Alexandra Schörg et al. NUCLEIC ACIDS RESEARCH
- Rate and mechanism of the photoreduction of birnessite (MnO2) nanosheets
- (2015) Francesco Femi Marafatto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection
- (2015) Ann E. Lin et al. PLoS Pathogens
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- The SIRT1/HIF2 Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
- (2014) C. Corbet et al. CANCER RESEARCH
- The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
- (2014) Thomas R. Cech et al. CELL
- Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
- (2014) Ramon C. Sun et al. Cell Metabolism
- Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
- (2014) Zoi Michailidou et al. DIABETES
- HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction
- (2014) L. Rahtu-Korpela et al. DIABETES
- Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
- (2014) Eric L. Campbell et al. IMMUNITY
- Hypoxia and Hypoxia-Inducible Factor-1 Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
- (2014) J. Jantsch et al. JOURNAL OF IMMUNOLOGY
- Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
- (2014) Hyun Mi Kang et al. NATURE MEDICINE
- Inverse association between diabetes and altitude: A cross-sectional study in the adult population of the United States
- (2014) Orison O. Woolcott et al. Obesity
- HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
- (2014) De Huang et al. Cell Reports
- Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
- (2013) Gregg L. Semenza Annual Review of Pathology-Mechanisms of Disease
- Hypoxia-Inducible Factor 1 and Cardiovascular Disease
- (2013) Gregg L. Semenza Annual Review of Physiology
- HypoxamiRs and Cancer: From Biology to Targeted Therapy
- (2013) Harriet E. Gee et al. ANTIOXIDANTS & REDOX SIGNALING
- Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade
- (2013) Analía Núñez-O’Mara et al. BIOLOGICAL CHEMISTRY
- Association of elevation, urbanization and ambient temperature with obesity prevalence in the United States
- (2013) J D Voss et al. INTERNATIONAL JOURNAL OF OBESITY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Restricted Expression of miR-30c-2-3p and miR-30a-3p in Clear Cell Renal Cell Carcinomas Enhances HIF2 Activity
- (2013) L. K. Mathew et al. Cancer Discovery
- Hypoxia-Inducible Factors in Physiology and Medicine
- (2012) Gregg L. Semenza CELL
- Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
- (2012) Laura E. Crotty Alexander et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia
- (2011) Guo-Min Shen et al. BIOCHEMICAL JOURNAL
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 Activity during Prolonged Hypoxia
- (2011) U. Bruning et al. MOLECULAR AND CELLULAR BIOLOGY
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolutionary Conserved Regulation of HIF-1β by NF-κB
- (2011) Patrick van Uden et al. PLoS Genetics
- The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
- (2010) Na Zhang et al. Cell Metabolism
- Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
- (2010) Murtaza M. Tambuwala et al. GASTROENTEROLOGY
- Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
- (2010) F Zhao et al. ONCOGENE
- Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans
- (2010) Cormac T. Taylor et al. PHYSIOLOGY
- Regulation of human metabolism by hypoxia-inducible factor
- (2010) Federico Formenti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia
- (2009) Cormac T. Taylor et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway
- (2009) Nobuko Koshikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
- (2009) David R. Mole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
- (2009) G. Bellot et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of hypoxia-inducible factor-1α by NF-κB
- (2008) Patrick van Uden et al. BIOCHEMICAL JOURNAL
- Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
- (2008) Huafeng Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1 RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells
- (2008) G. Niu et al. MOLECULAR CANCER RESEARCH
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Mitochondria and cellular oxygen sensing in the HIF pathway
- (2007) Cormac T. Taylor BIOCHEMICAL JOURNAL
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